Results 261 to 270 of about 45,099 (293)

The chaperone like function of the nonhistone protein HMGB1

Biochemical and Biophysical Research Communications, 2013
Almost all essential nuclear processes as replication, repair, transcription and recombination require the chromatin template to be correctly unwound and than repackaged. The major strategy that the cell uses to overcome the nucleosome barrier is the proper removal of the histone octamer and subsequent deposition onto DNA.
Taner, Osmanov, Iva, Ugrinova, Evdokia, Pasheva   +2 more
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The Role of Glycyrrhizin, an Inhibitor of HMGB1 Protein, in Anticancer Therapy

Archivum Immunologiae et Therapiae Experimentalis, 2012
Certain anticancer drugs, such as the peptide CAMEL (aa sequence KWKLFKKIGAULKVL) induce necrotic type of cell death. During this process, a protein termed high mobility group box 1 (HMGB1) is released from cell nucleus into cytoplasm and then into extracellular milieu. Outside of cells, it becomes a proinflammatory cytokine.
Smolarczyk, R., Cichoń, T., Matuszczak, S., Mitrus, I., Lesiak, M., Kobusińska, M., Wojciech Kamysz, Jarosz, M., Sieroń, A., Szala, S.   +9 more
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The effect of PKC phosphorylation on the “architectural” properties of HMGB1 protein

Molecular Biology Reports, 2012
High mobility group box (HMGB)1 protein acts as an architectural element, promoting the assembly of active nucleoprotein complexes due to its ability to bend DNA and to bind preferentially to distorted DNA structures. The behavior of HMGB1 as an "architect" of chromatin defines it as an important factor in many cellular processes such as repair ...
Iva, Ugrinova, Stanislava, Zlateva, Evdokia, Pasheva   +2 more
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[Structural organization of DNA complexes with proteins HMGB1 and HMGB1-(A+B)].

Biofizika, 2008
The interaction between DNA and the nonhistone proteins HMGB1 and HMGB1-(A+B) has been studied using circular dichroism and scanning force microscopy. The recombinant protein HMGB1-(A+B) has no negatively charged C-terminal domain characteristic for HMGB1.
A M, Polianichko, Z V, Leonenko, D, Kramb, G, Vieser, V I, Vorob'ev, E V, Chikhirzhina   +5 more
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HMGB1 and HMGB2 proteins in ferroptosis, cancer, and neurodegeneration

Medical Research Archives
Introduction High mobility group box (HMGB) proteins are nuclear DNA-binding factors that, once released from the nucleus, behave as damage-associated molecular patterns (DAMPs) capable of activating pattern recognition receptors (PRRs). The role of HMGB1 in cell death has been characterized in considerable detail, whereas HMGB2 has only lately been ...
Ian A Blair, Jingqi Fan, Jia Liu
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HMGB1 secretion is regulated by protein kinase C (89.26)

The Journal of Immunology, 2007
Abstract High mobility group box-1 protein (HMGB1) is secreted from activated monocytes/macrophages and known as a key late mediator of sepsis, so the regulation of secretion is important to control the sepsis. Phosphorylation of HMGB1 is one of major secretion pathways in our previous report.
Young Joo Oh, Ju Ho Youn, Jeon Soo Shin
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Changes in the secondary structure of HMGB1 protein bonded to DNA

Journal of Structural Chemistry, 2009
The stage of noncooperative interaction of the chromosomal nonhistone protein HMGB1 with DNA has been studied by spectroscopic methods and gel retardation. It was found that complexation was accompanied by compaction of the DNA molecule over a wide range of protein/DNA ratios in the complex.
T. Yu. Rodionova, E. V. Chikhirzhina, V. I. Vorob’yov, A. M. Polyanichko   +3 more
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RAG and HMGB1 Proteins: Purification and Biochemical Analysis of Recombination Signal Complexes

2006
Two lymphoid cell-specific proteins, called RAG-1 and RAG-2, initiate the process of antigen receptor gene rearrangement, termed V(D)J recombination, by assembling a protein-DNA complex with two recombination signal sequences (RSSs), each of which adjoins a different receptor gene segment, and then introducing a DNA double strand break at the end of ...
Serge, Bergeron, Dirk K, Anderson, Patrick C, Swanson   +2 more
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The cytokine activity of HMGB1--extracellular escape of the nuclear protein.

Chang Gung medical journal, 2006
High mobility group box 1 (HMGB1), a mobile chromatin protein, passively leaks from necrotic cells and signals neighboring cells that tissue damage has occurred. Resting, non-activated inflammatory cells such as monocytes or macrophages contain HMGB1 in the nuclear compartment.
Nian-Kang, Sun, Chuck C K, Chao
openaire   +1 more source

HMGB1 Protein

2017
I. Ugrinova, E. Pasheva
openaire   +1 more source