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Mechanistic investigation of HMGB1 in an in vitro model of the trigeminovascular system under migraine-like conditions. [PDF]
J Headache PainSong M +8 more
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The multifunctional protein HMGB1: 50 years of discovery
Nature Reviews Immunology, 2023Fifty years since the initial discovery of HMGB1 in 1973 as a structural protein of chromatin, HMGB1 is now known to regulate diverse biological processes depending on its subcellular or extracellular localization. These functions include promoting DNA damage repair in the nucleus, sensing nucleic acids and inducing innate immune responses and ...
Daolin Tang, , Michael Lotze
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Release of chromatin protein HMGB1 by necrotic cells triggers inflammation
Nature, 2002High mobility group 1 (HMGB1) protein is both a nuclear factor and a secreted protein. In the cell nucleus it acts as an architectural chromatin-binding factor that bends DNA and promotes protein assembly on specific DNA targets. Outside the cell, it binds with high affinity to RAGE (the receptor for advanced glycation end products) and is a potent ...
Paola Scaffidi +2 more
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Evidence for the binding affinity of daunomycin to HMGB1 protein in chromatin and in solution
International Journal of Biological Macromolecules, 2013In this study the interaction of daunomycin with HMGB1 nonhistone chromatin protein in the chromatin context using hydroxyapatite (HAP) column chromatography and free in solution was investigated employing fluorescence, circular dichroism spectroscopy and thermal denaturation techniques.
Parinaz Ghadam, Azra Rabbani-Chadegani
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Interplay between in vitro acetylation and phosphorylation of tailless HMGB1 protein
Biochemical and Biophysical Research Communications, 2009The postsynthetic acetylation of HMGB1 protein and its truncated form affects significantly its properties as "architectural" factor - recognition of bent DNA and bending of short DNA fragments. We created mutants at the target sites (lysines 2 and 81) in the tailless HMGB1 modified by the histone acetyltransferase CBP.
Evdokia Pasheva, Iliya G Pashev
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The redox protein HMGB1 in cell death and cancer
Antioxidants & Redox Signaling, 2023As a redox-sensitive protein, high-mobility group box 1 (HMGB1) is implicated in regulating stress responses to oxidative damage and cell death, which are closely related to the pathology of inflammatory diseases, including cancer.HMGB1 is a non-histone nuclear protein that acts as a DNA chaperone to control chromosomal structure and function.
Ruochan, Chen +3 more
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