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[Structural organization of DNA complexes with proteins HMGB1 and HMGB1-(A+B)].
Biofizika, 2008The interaction between DNA and the nonhistone proteins HMGB1 and HMGB1-(A+B) has been studied using circular dichroism and scanning force microscopy. The recombinant protein HMGB1-(A+B) has no negatively charged C-terminal domain characteristic for HMGB1.
A M, Polianichko +5 more
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HMGB1 secretion is regulated by protein kinase C (89.26)
The Journal of Immunology, 2007Abstract High mobility group box-1 protein (HMGB1) is secreted from activated monocytes/macrophages and known as a key late mediator of sepsis, so the regulation of secretion is important to control the sepsis. Phosphorylation of HMGB1 is one of major secretion pathways in our previous report.
Young Joo Oh, Ju Ho Youn, Jeon Soo Shin
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Changes in the secondary structure of HMGB1 protein bonded to DNA
Journal of Structural Chemistry, 2009The stage of noncooperative interaction of the chromosomal nonhistone protein HMGB1 with DNA has been studied by spectroscopic methods and gel retardation. It was found that complexation was accompanied by compaction of the DNA molecule over a wide range of protein/DNA ratios in the complex.
T. Yu. Rodionova +3 more
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RAG and HMGB1 Proteins: Purification and Biochemical Analysis of Recombination Signal Complexes
2006Two lymphoid cell-specific proteins, called RAG-1 and RAG-2, initiate the process of antigen receptor gene rearrangement, termed V(D)J recombination, by assembling a protein-DNA complex with two recombination signal sequences (RSSs), each of which adjoins a different receptor gene segment, and then introducing a DNA double strand break at the end of ...
Serge, Bergeron +2 more
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The cytokine activity of HMGB1--extracellular escape of the nuclear protein.
Chang Gung medical journal, 2006High mobility group box 1 (HMGB1), a mobile chromatin protein, passively leaks from necrotic cells and signals neighboring cells that tissue damage has occurred. Resting, non-activated inflammatory cells such as monocytes or macrophages contain HMGB1 in the nuclear compartment.
Nian-Kang, Sun, Chuck C K, Chao
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HMGB1 Protein: Regulation by Specific E3 Ubiquitin Ligases
Genes & CellsHMGB1 belongs to the high mobility group (HMG) protein family, characterized by the presence of structurally conserved DNA-binding HMGB domain. In addition to two DNA-binding domains connected by a short linker, HMGB1 contains a short N-terminal sequence and an intrinsically disordered C-terminal region.
Elena V. Chikhirzhina +2 more
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The Role of HMGB1 Protein in the Regulation of Inflammation and Bone Remodeling
The present study is a scoping review and will follow the methodology proposed by the Joanna Briggs Institute (JBI). The reporting and results will adhere to the PRISMA-ScR guidelines, ensuring transparency, reproducibility, and scientific standardization.Guimarães, Ana Flávia César +5 more
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HMGB1 Protein: A Therapeutic Target Inside and Outside the Cell.
Advances in protein chemistry and structural biology, 2017High-mobility group box 1 protein (HMGB1) is a nonhistone chromosomal protein discovered more than 30 years ago. It is an abundant nuclear protein that has a dual function-in the nucleus, it binds DNA and participates in practically all DNA-dependent processes serving as an architectural factor. Outside the cell, HMGB1 plays a different role-it acts as
I, Ugrinova, E, Pasheva
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Secretory autophagy machinery and vesicular trafficking are involved in HMGB1 secretion
Autophagy, 2021Young Hun Kim, Man Sup Kwak, Bin Lee
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