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Analysis of glycyrrhizin binding to protein HMGB1
Medicine in Drug Discovery, 2020 Glycyrrhizin (GLR) is triterpenoid saponin used for the treatment of various of liver and skin diseases. GLR blocks the nucleocytoplasmic translocation of the protein HMGB1, thereby inhibiting its extracellular release and its functions as a damage-associated molecular pattern molecule.
Christian Bailly
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The redox protein HMGB1 in cell death and cancer
Antioxidants & Redox Signaling, 2023As a redox-sensitive protein, high-mobility group box 1 (HMGB1) is implicated in regulating stress responses to oxidative damage and cell death, which are closely related to the pathology of inflammatory diseases, including cancer.HMGB1 is a non-histone nuclear protein that acts as a DNA chaperone to control chromosomal structure and function.
Ruochan, Chen +3 more
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The chaperone like function of the nonhistone protein HMGB1
Biochemical and Biophysical Research Communications, 2013Almost all essential nuclear processes as replication, repair, transcription and recombination require the chromatin template to be correctly unwound and than repackaged. The major strategy that the cell uses to overcome the nucleosome barrier is the proper removal of the histone octamer and subsequent deposition onto DNA.
Taner, Osmanov +2 more
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Release of chromatin protein HMGB1 by necrotic cells triggers inflammation
Nature, 2002High mobility group 1 (HMGB1) protein is both a nuclear factor and a secreted protein. In the cell nucleus it acts as an architectural chromatin-binding factor that bends DNA and promotes protein assembly on specific DNA targets. Outside the cell, it binds with high affinity to RAGE (the receptor for advanced glycation end products) and is a potent ...
Paola Scaffidi +2 more
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The Role of Glycyrrhizin, an Inhibitor of HMGB1 Protein, in Anticancer Therapy
Archivum Immunologiae et Therapiae Experimentalis, 2012Certain anticancer drugs, such as the peptide CAMEL (aa sequence KWKLFKKIGAULKVL) induce necrotic type of cell death. During this process, a protein termed high mobility group box 1 (HMGB1) is released from cell nucleus into cytoplasm and then into extracellular milieu. Outside of cells, it becomes a proinflammatory cytokine.
Ryszard, Smolarczyk +9 more
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Evidence for the binding affinity of daunomycin to HMGB1 protein in chromatin and in solution
International Journal of Biological Macromolecules, 2013In this study the interaction of daunomycin with HMGB1 nonhistone chromatin protein in the chromatin context using hydroxyapatite (HAP) column chromatography and free in solution was investigated employing fluorescence, circular dichroism spectroscopy and thermal denaturation techniques.
Azra Rabbani-Chadegani, Parinaz Ghadam
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The effect of PKC phosphorylation on the “architectural” properties of HMGB1 protein
Molecular Biology Reports, 2012High mobility group box (HMGB)1 protein acts as an architectural element, promoting the assembly of active nucleoprotein complexes due to its ability to bend DNA and to bind preferentially to distorted DNA structures. The behavior of HMGB1 as an "architect" of chromatin defines it as an important factor in many cellular processes such as repair ...
Iva, Ugrinova +2 more
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Interplay between in vitro acetylation and phosphorylation of tailless HMGB1 protein
Biochemical and Biophysical Research Communications, 2009The postsynthetic acetylation of HMGB1 protein and its truncated form affects significantly its properties as "architectural" factor - recognition of bent DNA and bending of short DNA fragments. We created mutants at the target sites (lysines 2 and 81) in the tailless HMGB1 modified by the histone acetyltransferase CBP.
Iliya G Pashev, Evdokia Pasheva
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High-mobility group box 1 (HMGB1) protein: Friend and foe
Cytokine and Growth Factor Reviews, 2006HMGB1 was originally identified as a DNA-binding protein that functions as a structural co-factor critical for proper transcriptional regulation in somatic cells. Recent studies indicate that HMGB1 can be "passively released" into the extracellular milieu by necrotic and damaged somatic cells. Extracellular HMGB1 represents an optimal "necrotic marker"
Luis Ulloa, Davorka Messmer
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The expression of HMGB1 protein and its receptor RAGE in human malignant tumors
Molecular and Cellular Biochemistry, 2009High Mobility Group Box 1 (HMGB1) is a nuclear non-histone protein discovered to be released in the extracellular medium as a response to various stimuli and implicated in cancerogenesis. High HMGB1 levels are reported in a variety of tumor types, but there are few data relating HMGB1 to the histological grade or to a particular cell type and cellular ...
Nora N Kostova +2 more
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