Results 81 to 90 of about 8,776 (182)

Homoploid hybridization of plants in the Hengduan mountains region

Ecology and Evolution, 2019
The Hengduan Mountains Region (HMR) is a major global biodiversity hotspot. Complex tectonic and historical climatic conditions created opportunities for natural interspecific hybridization.
Rui Yang, Ryan Folk, Ningning Zhang, Xun Gong   +3 more
doaj   +1 more source

The Integrity of the HMR complex is necessary for centromeric binding and reproductive isolation in Drosophila.

PLoS Genetics, 2021
Postzygotic isolation by genomic conflict is a major cause for the formation of species. Despite its importance, the molecular mechanisms that result in the lethality of interspecies hybrids are still largely unclear. The genus Drosophila, which contains
Andrea Lukacs, Andreas W Thomae, Peter Krueger, Tamas Schauer, Anuroop V Venkatasubramani, Natalia Y Kochanova, Wasim Aftab, Rupam Choudhury, Ignasi Forne, Axel Imhof   +9 more
doaj   +1 more source

Drugs of the 21st century: telithromycin (HMR 3647)--the first ketolide [PDF]

Journal of Antimicrobial Chemotherapy, 2003
Telithromycin (HMR 3647) is the first ketolide introduced into clinical practice. Ketolides are semisynthetic derivates of erythromycin A that carry novel biological properties on the erythronolide A ring. This new class of antimicrobials was designed to overcome current resistance mechanisms against erythromycin A within Gram-positive cocci. Ketolides
Grit, Ackermann, Arne C, Rodloff
openaire   +2 more sources

Hemoglobin-to-RDW ratio, hemoglobin-to-monocyte ratio, and hemoglobin-to-leukocyte ratio are predictive of 14-day readmission after primary total knee arthroplasty

Journal of Orthopaedic Surgery and Research
Background Total knee arthroplasty (TKA) is an effective treatment for knee osteoarthritis; however, early readmissions due to complications are common.
Ngi-Chiong Lau, Chih-Chien Hu, Yu-Yi Huang, Pin-Ren Huang, Dave W. Chen   +4 more
doaj   +1 more source

Unveiling the Microvasculature: The Index of Microcirculatory Resistance and Its Expanding Role in Cardiovascular Care

Catheterization and Cardiovascular Interventions, Volume 108, Issue 2, Page 287-300, August 1, 2026.
ABSTRACT Index of microcirculatory resistance (IMR) is a cutting‐edge, wire‐based tool that advances the capability assessment of coronary microvascular function. By utilizing distal coronary pressure and mean transit time under maximal hyperemia, IMR delivers consistent, reproducible insights into the microvasculature's dynamic health.
Joanna Sohn, Matthew A. Soderstrom, Ariana Ramirez, John‐Henry Dean, Raj Shah, Debanshu Roy, Kenneth Stone, Ariel Vinas, Bryan Ramsey, Charles Lin, Robert Chilton   +10 more
wiley   +1 more source

Induced Pluripotent Stem Cell Derivation and Ex Vivo Gene Correction Using a Mucopolysaccharidosis Type 1 Disease Mouse Model

Stem Cells International, 2019
Mucopolysaccharidosis type 1 (MPS-1), also known as Hurler’s disease, is a congenital metabolic disorder caused by a mutation in the alpha-L-iduronidase (IDUA) gene, which results in the loss of lysosomal enzyme function for the degradation of ...
Toshio Miki, Ludivina Vazquez, Lisa Yanuaria, Omar Lopez, Irving M. Garcia, Kazuo Ohashi, Natalie S. Rodriguez   +6 more
doaj   +1 more source

Multimodal Physical Therapy Management of Dysmenorrhea With Coexisting Mechanical Low Back Pain and Early Degenerative Lumbar Spondylosis: A Case Report

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT A 21‐year‐old woman with dysmenorrhea, mechanical low back pain, early lumbar spondylosis, heavy menstrual bleeding, and anemia received 4 weeks of multimodal physiotherapy. Pain and function improved, but heavy bleeding created diagnostic uncertainty; menstrual flow and hemoglobin changes were interpreted cautiously and not attributed to ...
Nadia Afrin Urme, Asma Islam, Fabiha Alam, Md Rifat Haidar, Md Waliul Islam, Ranu Islam, Polok Halder   +6 more
wiley   +1 more source

Novel heavy metal resistance gene clusters are present in the genome of Cupriavidus neocaledonicus STM 6070, a new species of Mimosa pudica microsymbiont isolated from heavy-metal-rich mining site soil

BMC Genomics, 2020
Background Cupriavidus strain STM 6070 was isolated from nickel-rich soil collected near Koniambo massif, New Caledonia, using the invasive legume trap host Mimosa pudica.
Agnieszka Klonowska, Lionel Moulin, Julie Kaye Ardley, Florence Braun, Margaret Mary Gollagher, Jaco Daniel Zandberg, Dora Vasileva Marinova, Marcel Huntemann, T. B. K. Reddy, Neha Jacob Varghese, Tanja Woyke, Natalia Ivanova, Rekha Seshadri, Nikos Kyrpides, Wayne Gerald Reeve   +14 more
doaj   +1 more source

SARS‐CoV‐2 Spike Peptides Trigger Nociceptive Responses Through Spinal TLR4 Pathways

European Journal of Pain, Volume 30, Issue 7, August 2026.
ABSTRACT Background Pain is a common neurological manifestation of COVID‐19, yet the mechanisms by which SARS‐CoV‐2 spike protein fragments contribute to nociceptive processing remain poorly understood. We investigated whether spike‐derived peptides directly activate spinal neuroimmune pathways involved in pain signalling.
Bruno Eduardo Silva, Rayner Ribeiro Cardoso, Lívia Maria Ribeiro Rosário, João Paulo Prado, Rafaela Silva dos Santos, Flávio Protasio Veras, Mylena de Souza, Eduardo Maffud Cilli, Danilo Olivier, Marco Antonio de Andrade Belo, Ives Charlie‐Silva, Ester Siqueira Caixeta, Angel Roberto Barchuk, Albená Nunes‐Silva, Thiago Roberto Lima Romero, Giovane Galdino   +15 more
wiley   +1 more source

Seasonal Trends, Environmental Drivers, and Lessons Learned From the 2023 Cholera Outbreak in Chattogram, Bangladesh: A Descriptive Study

Health Science Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background and Aims Acute watery diarrhea (AWD) remains a major global public health problem, and cholera continues to cause substantial morbidity and mortality in settings with inadequate water, sanitation, and hygiene (WASH). Chattogram, a coastal district of Bangladesh, is particularly vulnerable due to seasonal hydroclimatic changes ...
Immamul Muntasir, Md. Jahidur Rahman, Sayik Bin Alam, Abir Shaqran Mahmood, Tanvir Ahmed, Mithun Bahadur, Farzana Islam Khan, Kyaw Thowai Prue Prince, Mohammad Rashedul Hassan, Zakir Hossain Habib, Tahmina Shirin   +10 more
wiley   +1 more source