Effect of institutional antimicrobial stewardship guidelines on prescription of critically important antimicrobials for dogs and cats [PDF]
Journal of Veterinary Internal MedicineBackground Veterinary hospital antimicrobial stewardship (AMS) guidelines might help combat antimicrobial resistance (AMR). Objectives Determine the conditions and types of infection for which antimicrobial drugs (AMDs) deemed critically important (CIA ...
Sarah N. Robbins +3 more
doaj +3 more sources
Resistance to ketolide antibiotics by coordinated expression of rRNA methyltransferases in a bacterial producer of natural ketolides [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2015 Significance Studies of antibiotic resistance are usually initiated in earnest only after resistance has become established in clinical pathogens.
Simon Rose +2 more
exaly +8 more sources
Structural and mechanistic basis for translation inhibition by macrolide and ketolide antibiotics [PDF]
Nature Communications, 2021 Macrolides and ketolides comprise a family of clinically important antibiotics that inhibit protein synthesis by binding within the exit tunnel of the bacterial ribosome.
Bertrand Beckert +13 more
doaj +2 more sources
Determination of In Vitro Antimicrobial Susceptibility for Lefamulin (Pleuromutilin) for Ureaplasma Spp. and Mycoplasma hominis [PDF]
Antibiotics, 2021 Lefamulin is the first of the pleuromutilin class of antimicrobials to be available for therapeutic use in humans. Minimum inhibitory concentrations of lefamulin were determined by microbroth dilution for 90 characterised clinical isolates (25 Ureaplasma
Oliver Spiller-Boulter +5 more
doaj +2 more sources
Intravenous azithromycin plus ceftriaxone followed by oral azithromycin for the treatment of inpatients with community-acquired pneumonia: an open-label, non-comparative multicenter trial [PDF]
Brazilian Journal of Infectious Diseases, 2008 Community-Acquired Pneumonia (CAP) is a major public health problem. In Brazil it has been estimated that 2,000,000 people are affected by CAP every year. Of those, 780,000 are admitted to hospital, and 30,000 have death as the outcome.
Fernando G. Rubio +12 more
doaj +2 more sources
Antibiotic innovation may contribute to slowing the dissemination of multiresistant Streptococcus pneumoniae: the example of ketolides. [PDF]
PLoS ONE, 2008 BackgroundDespite increasingly frequent bacterial resistance to antibiotics, antibacterial innovation is rare. Ketolides constitute one of the very few new antibiotic classes active against Streptococcus pneumoniae developed during the last 25 years ...
Lulla Opatowski +6 more
doaj +1 more source
Results in Chemistry, 2023 Ketolides are the fourth generation semisynthetic macrolides derived from erythromycin A, designed to address the limitations of currently available drug treatments including penicillins, macrolides and glycopeptides.
Satish Bhavsar +10 more
doaj +1 more source
Emerging Treatment Options for Infections by Multidrug-Resistant Gram-Positive Microorganisms
Microorganisms, 2020 Antimicrobial agents are currently the mainstay of treatment for bacterial infections worldwide. However, due to the increased use of antimicrobials in both human and animal medicine, pathogens have now evolved to possess high levels of multi-drug ...
Despoina Koulenti +7 more
doaj +1 more source
Scaffold Modifications in Erythromycin Macrolide Antibiotics. A Chemical Minireview
Molecules, 2020 Clarithromycin and congeners are important antibacterial members of the erythromycin A 14-membered macrocyclic lactone family. The macrolide scaffold consists of a multifunctional core that carries both chemically reactive and non-reactive substituents ...
Kjell Undheim
doaj +1 more source
Nature Communications, 2023 The ever-growing rise of antibiotic resistance among bacterial pathogens is one of the top healthcare threats today. Although combination antibiotic therapies represent a potential approach to more efficiently combat infections caused by susceptible and ...
Chih-Wei Chen +7 more
doaj +1 more source