ECDC, EFSA and EMA Joint Scientific Opinion on a list of outcome indicators as regards surveillance of antimicrobial resistance and antimicrobial consumption in humans and food‐producing animals [PDF]
Abstract ECDC, EFSA and EMA have jointly established a list of harmonised outcome indicators to assist EU Member States in assessing their progress in reducing the use of antimicrobials and antimicrobial resistance (AMR) in both humans and food‐producing animals. The proposed indicators have been selected on the basis of data collected by Member States
Reilly, Jacqui
core +2 more sources
Ceftiofur use and antimicrobial stewardship in the horse
Abstract Equine practitioners require recommendations that support antimicrobial stewardship and avoid generating resistance to medically important antibiotics. This review examines current inadequacies in antimicrobial stewardship standards within the veterinary community, related to antimicrobial categorisation and prescribing practices.
Clare A. Ryan +2 more
wiley +1 more source
Antimicrobial prescribing and antimicrobial resistance surveillance in equine practice
Abstract Background Antimicrobial resistance (AMR) is an increasingly serious threat to human and animal health, therefore responsible use of antimicrobials in equine practice is vital. There is a need to have accurate, up to date data on antimicrobial prescribing in equine practice in the UK.
Amie Wilson +4 more
wiley +1 more source
A framework for evaluation of on‐farm mastitis diagnostics in Australia
Numerous culture‐based diagnostics are available on the Australian and international markets for on‐farm detection of bacterial pathogens in milk. Use of such diagnostics may provide an opportunity to improve the prudent use of antimicrobials in udder health management. Farms are low‐resource settings in terms of diagnostic microbiology capacity.
RN Zadoks +5 more
wiley +1 more source
From gut to mud: dissemination of antimicrobial resistance between animal and agricultural niches
Summary With increasing reports on antimicrobial resistance (AMR) in humans, animals and the environment, we are at risk of returning to a pre‐antibiotic era. Therefore, AMR is recognized as one of the major global health threats of this century. Antibiotics are used extensively in farming systems to treat and prevent infections in food animals or to ...
Niti B. Jadeja, Anja Worrich
wiley +1 more source
Abstract Pharmacokinetic/pharmacodynamic (PK/PD) modelling is the initial step in the semi‐mechanistic approach for optimizing dosage regimens for systemically acting antimicrobial drugs (AMDs). Numerical values of PK/PD indices are used to predict dose and dosing interval on a rational basis followed by confirmation in clinical trials. The value of PK/
Pierre‐Louis Toutain +5 more
wiley +1 more source
Ketolide Resistance Conferred by Short Peptides [PDF]
Clones expressing pentapeptides conferring resistance to a ketolide antibiotic, HMR3004, were selected from a random pentapeptide mini-gene library. The pentapeptide MRFFV conferred the highest level of resistance and was encoded in three different mini-genes. Comparison of amino acid sequences of peptides conferring resistance to a ketolide with those
S, Tripathi, P S, Kloss, A S, Mankin
openaire +2 more sources
Dead Bugs Don’t Mutate: Susceptibility Issues in the Emergence of Bacterial Resistance
The global emergence of antibacterial resistance among common and atypical respiratory pathogens in the last decade necessitates the strategic application of antibacterial agents.
Charles W. Stratton
doaj +1 more source
The aim of this study was to reduce antimicrobial use (AMU) on dairy farms that implemented evidence-based management strategies. The study not only examined whether these strategies led to a reduction in AMU in practice, but also examined the influence ...
Manuela Gerber +2 more
doaj +1 more source
Resistance decay in individuals after antibiotic exposure in primary care: A systematic review and meta-analysis [PDF]
Background Antibiotic resistance is an urgent global problem, but reversibility is poorly understood. We examined the development and decay of bacterial resistance in community patients after antibiotic use.
Bakhit, Mina +5 more
core +1 more source

