Results 31 to 40 of about 1,296 (184)
, 2014 Macrolides and ketolides are characterized by a very wide tissular distribution, which is related to their capacity to accumulate in the acidic compartments of the cells.
Van Bambeke, Françoise
core +1 more source
Ketolide Resistance Conferred by Short Peptides [PDF]
Journal of Biological Chemistry, 1998 Clones expressing pentapeptides conferring resistance to a ketolide antibiotic, HMR3004, were selected from a random pentapeptide mini-gene library. The pentapeptide MRFFV conferred the highest level of resistance and was encoded in three different mini-genes. Comparison of amino acid sequences of peptides conferring resistance to a ketolide with those
S, Tripathi, P S, Kloss, A S, Mankin
openaire +2 more sources
Annals of Clinical Microbiology and Antimicrobials, 2004 Background In streptococci, three macrolide resistance determinants (erm(B), erm(TR) and mef(A)) have been found. In addition, certain mutations at the ribosomal 23S RNA can cause resistance to macrolides. Mutation at the position 2058 of the 23S rRNA of
Huovinen Pentti +2 more
doaj +1 more source
Type III Secretion-Dependent Sensitivity of Escherichia coli O157 to Specific Ketolides [PDF]
, 2015 A subset of Gram negative bacterial pathogens use a type 3 secretion system (T3SS) to open up a conduit into eukaryotic cells in order to inject effector proteins. These modulate pathways to enhance bacterial colonization.
Tahoun, Amin +11 more
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New therapeutic approaches for treatment of tularaemia: a review
Frontiers in Cellular and Infection Microbiology, 2014 Antibiotic treatment of tularaemia is based on a few drugs, including the fluoroquinolones, the tetracyclines and the aminoglycosides. Because no effective and safe vaccine is currently available, tularaemia prophylaxis following proven exposure to F ...
Sandrine eBOISSET +7 more
doaj +1 more source
Synthesis and Antibacterial Activity of Novel C12 Vinyl Ketolides
, 2016 A novel series of C12 vinyl erythromycin derivatives have been discovered which exhibit in vitro and in vivo potency against key respiratory pathogens. The C12 modification involves replacing the natural C12 methyl group in the erythromycin core with a ...
Alice C. Rico (2648317) +15 more
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Synthesis and Structure−Activity Relationships of Novel 8a-Aza-8a-homoerythromycin A Ketolides
, 2016 A series of novel 6-O-substituted 8a-aza-8a-homoerythromycin A ketolides was synthesized and evaluated for in vitro antibacterial activity. Key strategic elements of the synthesis include the base-induced E−Z isomerization of 3-O-descladinosyl-6-O ...
Stjepan Mutak (1738849) +1 more
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Analysis of Virulence Genes and Antibiotic‐Resistant Profiles of Campylobacter in Huzhou, China
Canadian Journal of Infectious Diseases and Medical Microbiology, Volume 2026, Issue 1, 2026.Background Campylobacter is the leading bacterial cause of diarrheal illnesses worldwide. Campylobacter jejuni and Campylobacter coli are the main pathogens of Campylobacter infections. Drug‐resistant Campylobacter has been classified as a serious antibiotic resistance threat. Methods From 2021 to 2022, 68 Campylobacter were isolated from fecal samples
Xiaofang Wu +5 more
wiley +1 more source
Leclercia adecarboxylata Cholecystitis with Septic Shock in Immunocompetent Patient
Case Reports in Critical Care, Volume 2019, Issue 1, 2019., 2019 L. adecarboxylata is a Gram‐negative rod previously named Escherichia adecarboxylata, isolated as normal flora in the gut of animals including human stool. Most reported cases refer to immunocompromised patients with polymicrobial infections and water environments.
Nooraldin Merza +6 more
wiley +1 more source
BMC Infectious Diseases, 2019 Background Solithromycin, the fourth generation of ketolides, has been demonstrated potent antibacterial effect against commonly-isolated gram-positive strains. However, Staphylococcus aureus (S.
Weiming Yao +10 more
doaj +1 more source