Results 51 to 60 of about 1,296 (184)
South African actinobacteria: A treasure trove of novel bioactive metabolites for drug discovery
South African Journal of ScienceAlthough South Africa is known as one of the most biodiverse countries in the world, based on its unique plants and animals, microorganisms have received much less attention.
Kojo S. Acquah +2 more
doaj +1 more source
What is the role of microbial biotechnology and genetic engineering in medicine?
MicrobiologyOpen, Volume 13, Issue 2, April 2024.Microbial biotechnology, the technological application of microorganisms, has been instrumental in producing significant natural bioactive products. These include antibiotics, antifungals, anticancer drugs, antiparasitics, antivirals, immunosuppressants, toxoid vaccines, and therapeutic enzymes.
Fernando Santos‐Beneit
wiley +1 more source
, 2016 A series of novel 6-O-substituted homopropargyl ketolides was synthesized and evaluated against various erythromycin-resistant pathogens.
Angela M. Nilius (2531995) +6 more
core +1 more source
The energy landscape of the ribosome
Biopolymers, Volume 115, Issue 2, March 2024.Abstract The ribosome is a prototypical assembly that can be used to establish general principles and techniques for the study of biological molecular machines. Motivated by the fact that the dynamics of every biomolecule is governed by an underlying energy landscape, there has been great interest to understand and quantify ribosome energetics.
Sandra Byju +2 more
wiley +1 more source
Synthesis of Novel 6,11-O-Bridged Bicyclic Ketolides via a Palladium-Catalyzed Bis-allylation
, 2016 A bridging chemistry process was developed to form an ether bridge between 6-O and 11-O of erythromycin A via a tandem or stepwise palladium-catalyzed bis-π-allylation.
Ly Tam Phan (2701579) +6 more
core +1 more source
, 2016 An efficient synthesis of α-amino-γ-lactone ketolide (3) was developed, which provided a versatile intermediate for the incorporation of a variety of aryl and heteroaryl groups onto the C-21 position of clarithromycin via HBTU-mediated amidation.
Daniele Andreotti (1738852) +8 more
core +1 more source
Canadian Journal of Infectious Diseases and Medical Microbiology, 2009 BACKGROUND: The Canadian Ward Surveillance Study (CANWARD 2007) tested isolates collected from January to December 2007 from 12 Canadian hospitals to a range of antimicrobial agents.
Aleksandra K Wierzbowski +5 more
doaj +1 more source
, 2016 Respiratory tract bacterial strains are becoming increasingly resistant to currently marketed macrolide antibiotics. The current alternative telithromycin (1) from the newer ketolide class of macrolides addresses resistance but is hampered by serious ...
Joseph B. Penzien (2201149) +37 more
core +1 more source
Brazilian Journal of Infectious DiseasesCommunity-Acquired Pneumonia (CAP) is a major public health problem. In Brazil it has been estimated that 2,000,000 people are affected by CAP every year. Of those, 780,000 are admitted to hospital, and 30,000 have death as the outcome.
Fernando G. Rubio +12 more
doaj +1 more source
Structure–activity relationships of ketolides vs. macrolides
, 2001 Since their discovery, the macrolide antimicrobials have proved clinically valuable for the treatment of respiratory tract infections, offering coverage against a broad spectrum of pathogens and excellent tolerability.
Douthwaite, S.
core +1 more source