Results 21 to 30 of about 1,296 (184)

The pharmacokinetic/pharmacodynamic paradigm for antimicrobial drugs in veterinary medicine: Recent advances and critical appraisal

Journal of Veterinary Pharmacology and Therapeutics, Volume 44, Issue 2, Page 172-200, March 2021., 2021
Abstract Pharmacokinetic/pharmacodynamic (PK/PD) modelling is the initial step in the semi‐mechanistic approach for optimizing dosage regimens for systemically acting antimicrobial drugs (AMDs). Numerical values of PK/PD indices are used to predict dose and dosing interval on a rational basis followed by confirmation in clinical trials. The value of PK/
Pierre‐Louis Toutain, Ludovic Pelligand, Peter Lees, Alain Bousquet‐Mélou, Aude A. Ferran, John D. Turnidge   +5 more
wiley   +1 more source

Structural insights into the mechanism of overcoming Erm-mediated resistance by macrolides acting together with hygromycin-A

Nature Communications, 2023
The ever-growing rise of antibiotic resistance among bacterial pathogens is one of the top healthcare threats today. Although combination antibiotic therapies represent a potential approach to more efficiently combat infections caused by susceptible and ...
Chih-Wei Chen, Nadja Leimer, Egor A. Syroegin, Clémence Dunand, Zackery P. Bulman, Kim Lewis, Yury S. Polikanov, Maxim S. Svetlov   +7 more
doaj   +1 more source

Look and Outlook on Enzyme-Mediated Macrolide Resistance

Frontiers in Microbiology, 2018
Since their discovery in the early 1950s, macrolide antibiotics have been used in both agriculture and medicine. Specifically, macrolides such as erythromycin and azithromycin have found use as substitutes for β-lactam antibiotics in patients with ...
Tolou Golkar, Michał Zieliński, Albert M. Berghuis, Albert M. Berghuis   +3 more
doaj   +1 more source

Reducing Antimicrobial Use by Implementing Evidence-Based, Management-Related Prevention Strategies in Dairy Cows in Switzerland

Frontiers in Veterinary Science, 2021
The aim of this study was to reduce antimicrobial use (AMU) on dairy farms that implemented evidence-based management strategies. The study not only examined whether these strategies led to a reduction in AMU in practice, but also examined the influence ...
Manuela Gerber, Salome Dürr, Michèle Bodmer   +2 more
doaj   +1 more source

Pathomechanisms and Clinical Implications of Myasthenic Syndromes Exacerbated and Induced by Medical Treatments

Frontiers in Molecular Neuroscience, 2020
Myasthenic syndromes are typically characterized by muscle weakness and increased fatigability due to an impaired transmission at the neuromuscular junction (NMJ).
Martin Krenn, Anna Grisold, Philipp Wohlfarth, Jakob Rath, Hakan Cetin, Inga Koneczny, Inga Koneczny, Fritz Zimprich   +7 more
doaj   +1 more source

Impact of ribosomal modification on the binding of the antibiotic telithromycin using a combined grand canonical monte carlo/molecular dynamics simulation approach. [PDF]

PLoS Computational Biology, 2013
Resistance to macrolide antibiotics is conferred by mutation of A2058 to G or methylation by Erm methyltransferases of the exocyclic N6 of A2058 (E. coli numbering) that forms the macrolide binding site in the 50S subunit of the ribosome.
Meagan C Small, Pedro Lopes, Rodrigo B Andrade, Alexander D Mackerell   +3 more
doaj   +1 more source

Genetic analysis of methicillin‐susceptible Staphylococcus aureus clinical isolates: High prevalence of multidrug‐resistant ST239 with strong biofilm‐production ability

Journal of Clinical Laboratory Analysis, Volume 34, Issue 11, November 2020., 2020
Biofilm formation involves first, adhesion to surfaces mediated by the expression of different microbial surface components recognizing adhesive matrix molecules (MSCRAMMs) and second, production of polysaccharide intercellular adhesion (PIA) which mediates cell to cell adhesion. Biofilm protects the bacteria from host defenses and prevents delivery of
Hossein Goudarzi, Mehdi Goudarzi, Fattaneh Sabzehali, Maryam Fazeli, Alireza Salimi Chirani   +4 more
wiley   +1 more source

Effect of antimicrobial stewardship on antimicrobial prescriptions for selected diseases of dogs in Switzerland

Journal of Veterinary Internal Medicine, Volume 34, Issue 6, Page 2418-2431, November/December 2020., 2020
Abstract Background Antimicrobial stewardship programs (ASPs) are important tools to foster prudent antimicrobial use. Objective To evaluate antimicrobial prescriptions by Swiss veterinarians before and after introduction of the online ASP AntibioticScout.ch in December 2016.
Claudia Lehner, Alina Hubbuch, Kira Schmitt, Gertraud Schuepbach‐Regula, Barbara Willi, Meike Mevissen, Ruth Peter, Cedric R. Muentener, Hanspeter Naegeli, Simone Schuller   +9 more
wiley   +1 more source

Antimicrobial prescriptions and adherence to prudent use guidelines for selected canine diseases in Switzerland in 2016

Veterinary Record Open, Volume 7, Issue 1, 2020., 2020
Background Antimicrobial resistance is an increasing problem in human and veterinary medicine and is closely linked to the use of antimicrobials. The objective of this study was to describe antimicrobial prescriptions for selected canine diseases in Switzerland during 2016. Methods Dogs presented to two university hospitals and 14 private practices for
Bérénice Lutz, Claudia Lehner, Kira Schmitt, Barbara Willi, Gertraud Schüpbach, Meike Mevissen, Ruth Peter, Cedric Müntener, Hanspeter Naegeli, Simone Schuller   +9 more
wiley   +1 more source

In Vitro ADME, Preclinical Pharmacokinetics and Prediction of Human Pharmacokinetics of RBx14255, a Novel Ketolide with Pharmacodynamics Against Multidrug-Resistant Bacterial Pathogens

Journal of Pharmacy & Pharmaceutical Sciences, 2020
Purpose: The preclinical pharmacokinetic and pharmacodynamic properties of a potent fluoroketolide RBx14255 against Streptococcus pneumoniae and Haemophilus influenzae was compared with telithromycin and human clinical dose was predicted for preclinical ...
Trdib Chaira, Tarani Barman, VETHAKKANI SAMUEL RAJ   +2 more
doaj   +1 more source