Results 61 to 70 of about 103,036 (328)

Event‐related potentials during sustained attention and memory tasks: Utility as biomarkers for mild cognitive impairment

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2018
Introduction The objective of the study is to validate attention and memory tasks that elicit event‐related potentials (ERPs) for utility as sensitive biomarkers for early dementia.
Shani Waninger, Chris Berka, Amir Meghdadi, Marija S. Karic, Kimberly Stevens, Cinthya Aguero, Tatiana Sitnikova, David H. Salat, Ajay Verma   +8 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Exome Sequencing in Saudi Arabian Pediatric Kidney Disease Single-Center Cohort

Kidney International Reports
Introduction: In pediatric patients, monogenic causes are a significant contributor to kidney disease, ranging from approximately 10% in congenital anomalies of the kidney and urinary tract (CAKUT) to about 55% in renal ciliopathies. Exome sequencing has
Katharina Lemberg, Mohamed A. Shalaby, Elena Zion, Ken Saida, Kirollos Yousef, Ronen Schneider, Nils D. Mertens, Bshara Mansour, Caroline M. Kolvenbach, Lea M. Merz, Korbinian M. Riedhammer, Alina Braun, Selina Hölzel, Seyoung Yu, Kraisoon Lomjansook, Gina Kalkar, Daniel Marchuk, Izzeldin Elmubarak, Gijs A.C. Franken, Shirlee Shril, Sherif El Desoky, Jameela A. Kari, Florian Buerger, Friedhelm Hildebrandt   +23 more
doaj   +1 more source

GRcalculator: an online tool for calculating and mining dose–response data

BMC Cancer, 2017
Background Quantifying the response of cell lines to drugs or other perturbagens is the cornerstone of pre-clinical drug development and pharmacogenomics as well as a means to study factors that contribute to sensitivity and resistance. In dividing cells,
Nicholas A. Clark, Marc Hafner, Michal Kouril, Elizabeth H. Williams, Jeremy L. Muhlich, Marcin Pilarczyk, Mario Niepel, Peter K. Sorger, Mario Medvedovic   +8 more
doaj   +1 more source

Exploring the fate of heavy metals from mining and smelting activities in soil-crop system in Baiyin, NW China

Ecotoxicology and Environmental Safety, 2021
The activity and fate of heavy metals (HMs) from mining and smelting activities in farmland soil is of great significance to effectively prevent the excessive enrichment of HMs in crops.
Bihong He, Wei Wang, Rongyue Geng, Zhe Ding, Dongxia Luo, Junli Qiu, Guodong Zheng, Qiaohui Fan   +7 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Computational modeling of distinct neocortical oscillations driven by cell-type selective optogenetic drive: Separable resonant circuits controlled by low-threshold spiking and fast-spiking interneurons

Frontiers in Human Neuroscience, 2010
Selective optogenetic drive of fast spiking interneurons (FS) leads to enhanced local field potential (LFP) power across the traditional gamma frequency band (20-80Hz; Cardin et al., 2009).
Dorea Vierling-Claassen, Dorea Vierling-Claassen, Jessica Cardin, Christopher I Moore, Stephanie R Jones   +4 more
doaj   +1 more source

Calcium‐sensing receptor induces the apoptosis of chondrocytes in cooperation with phosphate transporter

FEBS Open Bio, EarlyView.
Excess Ca2+ ions activate the Calcium‐Sensing Receptor (CaSR), which subsequently drives the uptake of excess inorganic phosphate (Pi) via the Pi transporter (Pit−1) in chondrocytes. This mechanism causes a toxic increase in intracellular Pi concentration, ultimately leading to chondrocyte apoptosis and pathological mineralization. Excess extracellular
Sachie Nakatani, Hiroya Ueda, Ayumi Kawata, Yuki Sato, Kotomi Inomata, Hiroshi Mano, Masahiro Wada, Kenji Kobata   +7 more
wiley   +1 more source

Pseudogenes in human cancer

Frontiers in Medicine, 2015
Recent advances in the analysis of RNA-sequencing (RNA-seq) data have shown that pseudogenes are highly specific markers of cell identity and can be used as diagnostic and prognostic markers. Furthermore, genetically engineered mouse models have recently
Laura ePoliseno, Andrea eMarranci, Pier Paolo ePandolfi   +2 more
doaj   +1 more source

The Lx-T and Lx-sigma Relationships for Galaxy Clusters Revisited

, 1999
The relationships between the X-ray determined bolometric luminosity Lx, the temperature T of the intracluster gas, and the optical measured velocity dispersion sigma of the cluster galaxies are updated for galaxy clusters using the largest sample of 256
Adami C., Bardelli S., Bird C. M., Bohringer H., Briel U. G., Burke D. J., Danese L., Ebeling H., Edge A. C., Edge A. C., Edge A. C., Fabian A. C., Gioia I. M., Gomez P. L., Green M. R., Kaiser N., Kneib J. P., Le Borgne J. F., Li‐Zhi Fang, Mewe R., Mitchell R. J., Piccinotti G., Pierre M., Reimers D., Schindler S., Schindler S., Stein P., Ulrich M.-H., White D. A., Wu X.-P., Xiang‐Ping Wu, Yan‐Jie Xue   +31 more
core   +1 more source