Results 131 to 140 of about 138,247 (296)

In Vivo Production of HN Protein Increases the Protection Rates of a Minicircle DNA Vaccine against Genotype VII Newcastle Disease Virus. [PDF]

Vaccines (Basel), 2021
Wang Z, Zhao X, Wang Y, Sun C, Sun M, Gao X, Jia F, Shan C, Yang G, Wang J, Huang H, Shi C, Yang W, Qian A, Wang C, Jiang Y.   +15 more
europepmc   +1 more source

Biallelic Germline Inactivation of HROB Causes Primary Gonadal Insufficiency and is Potentially Associated with Colonic Polyposis Predisposition

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The Homologous Recombination Factor With OB‐Fold (HROB) plays a role in homologous recombination and DNA replication, where it enhances the MCM8‐MCM9 helicase complex activity. Recent findings link biallelic germline HROB variants to primary gonadal insufficiency (hypergonadotropic hypogonadism), a phenotype also associated with MCM8/MCM9 ...
Noah C. Helderman, Carli M. Tops, Jelmer Legebeke, Ting Yang, Marcos Díaz Gay, Diantha Terlouw, Lisa E. E. L. O. Lashley, Stefan Aretz, Anna K. Sommer, Mariona Terradas, Laura Valle, Richarda M. de Voer, Ludmil B. Alexandrov, Hans Morreau, Tom van Wezel, Maartje Nielsen   +15 more
wiley   +1 more source

Bistable Gradient Networks II: Storage Capacity and Behaviour Near Saturation

, 2002
We examine numerically the storage capacity and the behaviour near saturation of an attractor neural network consisting of bistable elements with an adjustable coupling strength, the Bistable Gradient Network (BGN).
A. Chrisanti, A. Hjelmfelt, D.J. Amit, D.J. Amit, D.J. Amit, G. Dechert, J.-P. Laplante, J.J. Hopfield, J.J. Hopfield, Michael Menzinger, O.M. Becker, P. McGraw, P. Wolynes, P.E. Leopold, Patrick N. McGraw, V. Booth, V. Chinarov, W. Hohmann, W. Hohmann, W. Hohmann, W.A. Little, W.A. Little   +21 more
core   +1 more source

De Novo Complex Genomic Rearrangement Spanning 2q31.1 in a Proband With Congenital Malformations: Genotype–Phenotype Correlation and Development of a CGR Detection Pipeline

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The 2q31 region is commonly associated with pathogenic alleles of the HOXD cluster leading to various clinical phenotypes related to skeletal development. We present a proband with tetralogy of Fallot and multiple congenital anomalies. Genomic variant screening including an in‐house CGR detection pipeline pairing genome sequencing (GS ...
Katherine Helle, Jesse D. Bengtsson, Mira Gandhi, Christopher M. Grochowski, Ming Yin Lun, Neha Sudhir, Shalini N. Jhangiani, Fritz J. Sedlazeck, Seema R. Lalani, Neil A. Hanchard, Claudia M. B. Carvalho   +10 more
wiley   +1 more source

Assignments of backbone 1H, 13C and 15N resonances in H-Ras (1–166) complexed with GppNHp at physiological pH [PDF]

, 2012
The small GTPase Ras is an important signaling molecule acting as a molecular switch in eukaryotic cells. Recent findings of global conformational exchange and a putative allosteric binding site in the G domain of Ras opened an avenue to understanding ...
Kovriguine, Evgueni, O\u27Connor, Casey
core   +1 more source

Alternative Translation Initiation in PRKN Delays the Onset of Parkinson's Disease and Offers a Therapeutic Target

Annals of Neurology, EarlyView.
Objective Biallelic variants in PRKN cause autosomal recessive Parkinson's disease (PD) with a median age at onset of 31 years. When evaluating the 16 previously published carriers of a homozygous deletion of Exon 2 from the International Parkinson's Disease and Movement Disorder Society Gene Database (MDSGene) database, the median age at onset is ...
Arian Hach, Katja Lohmann, Manabu Funayama, Poornima J. Menon, Eva‐Juliane Vollstedt, Teresa Kleinz, Hiroyo Yoshino, Suzanne Lesage, Britta Meier, Carolyn M. Sue, Jean‐Christophe Corvol, Alexis Brice, Nobutaka Hattori, Christine Klein, Aleksandar Rakovic   +14 more
wiley   +1 more source

A novel chimpanzee adenovirus vector vaccine for protection against infectious bronchitis and Newcastle disease in chickens

Veterinary Research
The development of effective poultry vaccines is crucial for maintaining flock health and productivity. In this study, we developed and evaluated a recombinant chimpanzee adenovirus vaccine (PAD-S1-HN) that simultaneously expresses the infectious ...
Chengyao Hou, Ruiqi Ni, Lijun Zhao, Wenjun Yan, Kailu Wang, Qinyuan Chu, Xinggui Chen, Hongning Wang, Xin Yang   +8 more
doaj   +1 more source

Seed mixture of oat and common vetch improved yields and water productivity by belowground root niche complementarity

Agricultural Water Management
Sustainable forage production on the Qinghai–Tibetan Plateau is constrained by limited nitrogen and water resources, which hinders sustainable livestock development.
Qianhu Ma, Yuying Shen, Zikui Wang
doaj   +1 more source

Analysis of DevR regulated genes in Mycobacterium tuberculosis

, 2014
The DevRS two component system of Mycobacterium tuberculosis is responsible for its dormancy in host and becomes operative under hypoxic condition. It is experimentally known that phosphorylated DevR controls the expression of several downstream genes in
Bandyopadhyay, Arnab, Banik, Suman K, Biswas, Soumi, Maity, Alok Kumar   +3 more
core   +1 more source

Stochastic phenotype transition of a single cell in an intermediate region of gene-state switching

, 2015
Multiple phenotypic states often arise in a single cell with different gene-expression states that undergo transcription regulation with positive feedback. Recent experiments have shown that at least in E.
Ge, Hao, Qian, Hong, Xie, Sunney Xiaoliang   +2 more
core   +1 more source