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Editorial: Long noncoding RNAs in cancer. [PDF]
Jiménez-Morales S, Khan K, Sharma U.
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Advances in exosomal non-coding RNAs in cervical cancer (Review). [PDF]
Xie X, Guan H, Li M, Gao W, Wu K.
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A bioinformatics and experimental study toward new therapeutic strategies: CXCL8 in gout progression. [PDF]
Zhang C +5 more
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HNF1A-AS1: A Tumor-associated Long Non-coding RNA
Current Pharmaceutical Design, 2022Background: Hepatocyte nuclear factor 1 homeobox A antisense RNA 1 (HNF1A-AS1) is a Long non-coding RNA (LncRNA) that participates in the occurrence and development of lots of tumors and is supposed to be a new biomarker. The text aims to illustrate the biological effect, specific mechanism and clinical significance of HNF1A-AS1 in various tumors ...
Chengfu Yuan, Zhuoying Du, Yuling Liu
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PRMT1 Contributes to HNF1A‐AS1‐mediated Regulation Network of CYP3A4 in Huh7 Cells
Cytochrome P450 (CYP) 3A4 is an important drug‐metabolizing enzyme in human liver. Abnormal activity of CYP3A4 may lead to drug accumulation or over‐speed drug clearance in the body, ultimately affecting clinical drug treatment. Huge individual differences in the expression and activity of CYP3A4 have been observed.
Mian Wu
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The Long Noncoding Rna Hnf1a-As1 with Dual Functions in the Regulation of Cytochrome P450 3a4
Biochemical Pharmacology, 2023Cytochrome P450 3A4 (CYP3A4) is the most important and abundant drug-metabolizing enzyme in the human liver. Inter-individual differences in the expression and activity of CYP3A4 affect clinical and precision medicine. Increasing evidence indicates that long noncoding RNAs (lncRNAs) play crucial roles in the regulation of CYP3A4 expression.
Yiting Wang +10 more
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Differential expression of
AbstractThe human hepatocyte nuclear factor 1 homeobox A (HNF1A) gene loci express the protein‐coding HNF1A transcript and a long non‐coding RNA in the anti‐sense (HNF1A‐AS1) direction. HNF1A‐AS1 is expressed in numerous types of cancers and poor clinical outcomes such as higher mortality rates, greater metastatic capacity, and poor prognosis of the ...
Zahra Sepehri +6 more
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Cancer Biotherapy and Radiopharmaceuticals, 2021
Background: Osteosarcoma (OS) is a primary malignant tumor in children and adolescents. Long noncoding RNA HNF1A antisense RNA 1 (HNF1A-AS1) is connected with OS development.
Xu Zhan
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Background: Osteosarcoma (OS) is a primary malignant tumor in children and adolescents. Long noncoding RNA HNF1A antisense RNA 1 (HNF1A-AS1) is connected with OS development.
Xu Zhan
exaly +3 more sources
lncRNA HNF1A‐AS1 modulates non–small cell lung cancer progression by targeting miR‐149‐5p/Cdk6
Journal of Cellular Biochemistry, 2019AbstractGrowing evidence have shown the important regulation of lncRNAs (long noncoding RNAs) in non–small cell lung cancer (NSCLC). lncRNA hepatocyte nuclear factor 1 homeobox A (HNF1A)‐antisense RNA 1 (AS1), an “oncogene”, was reported to regulate human tumors progression.
Lu Liu
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Journal of Molecular Neuroscience, 2020
Multiple sclerosis (MS) is a complex genetic trait characterized by demyelination of central nervous system (CNS), inflammation, and progressive neurological dysfunction. There is evidenced that autophagy and stress mechanisms are tightly linked with MS.
Tayyeb Bahrami +3 more
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Multiple sclerosis (MS) is a complex genetic trait characterized by demyelination of central nervous system (CNS), inflammation, and progressive neurological dysfunction. There is evidenced that autophagy and stress mechanisms are tightly linked with MS.
Tayyeb Bahrami +3 more
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