Results 121 to 130 of about 9,918 (148)

Editorial: Long noncoding RNAs in cancer. [PDF]

open access: yesFront Oncol
Jiménez-Morales S, Khan K, Sharma U.
europepmc   +1 more source
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HNF1A-AS1: A Tumor-associated Long Non-coding RNA

Current Pharmaceutical Design, 2022
Background: Hepatocyte nuclear factor 1 homeobox A antisense RNA 1 (HNF1A-AS1) is a Long non-coding RNA (LncRNA) that participates in the occurrence and development of lots of tumors and is supposed to be a new biomarker. The text aims to illustrate the biological effect, specific mechanism and clinical significance of HNF1A-AS1 in various tumors ...
Chengfu Yuan, Zhuoying Du, Yuling Liu
exaly   +3 more sources

PRMT1 Contributes to HNF1A‐AS1‐mediated Regulation Network of CYP3A4 in Huh7 Cells

open access: yesFASEB Journal, 2021
Cytochrome P450 (CYP) 3A4 is an important drug‐metabolizing enzyme in human liver. Abnormal activity of CYP3A4 may lead to drug accumulation or over‐speed drug clearance in the body, ultimately affecting clinical drug treatment. Huge individual differences in the expression and activity of CYP3A4 have been observed.
Mian Wu
exaly   +2 more sources

The Long Noncoding Rna Hnf1a-As1 with Dual Functions in the Regulation of Cytochrome P450 3a4

Biochemical Pharmacology, 2023
Cytochrome P450 3A4 (CYP3A4) is the most important and abundant drug-metabolizing enzyme in the human liver. Inter-individual differences in the expression and activity of CYP3A4 affect clinical and precision medicine. Increasing evidence indicates that long noncoding RNAs (lncRNAs) play crucial roles in the regulation of CYP3A4 expression.
Yiting Wang   +10 more
openaire   +2 more sources

Differential expression of HNF1A and HNF1A‐AS1 in colon cancer cells

IUBMB Life, 2022
AbstractThe human hepatocyte nuclear factor 1 homeobox A (HNF1A) gene loci express the protein‐coding HNF1A transcript and a long non‐coding RNA in the anti‐sense (HNF1A‐AS1) direction. HNF1A‐AS1 is expressed in numerous types of cancers and poor clinical outcomes such as higher mortality rates, greater metastatic capacity, and poor prognosis of the ...
Zahra Sepehri   +6 more
openaire   +2 more sources

Long Noncoding RNA HNF1A-AS1 Regulates Osteosarcoma Advancement Through Modulating the miR-32-5p/HMGB1 Axis

Cancer Biotherapy and Radiopharmaceuticals, 2021
Background: Osteosarcoma (OS) is a primary malignant tumor in children and adolescents. Long noncoding RNA HNF1A antisense RNA 1 (HNF1A-AS1) is connected with OS development.
Xu Zhan
exaly   +3 more sources

lncRNA HNF1A‐AS1 modulates non–small cell lung cancer progression by targeting miR‐149‐5p/Cdk6

Journal of Cellular Biochemistry, 2019
AbstractGrowing evidence have shown the important regulation of lncRNAs (long noncoding RNAs) in non–small cell lung cancer (NSCLC). lncRNA hepatocyte nuclear factor 1 homeobox A (HNF1A)‐antisense RNA 1 (AS1), an “oncogene”, was reported to regulate human tumors progression.
Lu Liu
exaly   +3 more sources

Associations Between Genomic Variants in lncRNA-TRPM2-AS and lncRNA-HNF1A-AS1 Genes and Risk of Multiple Sclerosis

Journal of Molecular Neuroscience, 2020
Multiple sclerosis (MS) is a complex genetic trait characterized by demyelination of central nervous system (CNS), inflammation, and progressive neurological dysfunction. There is evidenced that autophagy and stress mechanisms are tightly linked with MS.
Tayyeb Bahrami   +3 more
openaire   +2 more sources

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