Results 11 to 20 of about 113,217 (197)

Structures of the CcmABCD heme release complex at multiple states

Nature Communications, 2022
Bacterial ABC transporter complex CcmABCD, a part of cytochrome c maturation system, transfers heme from one binding partner (CcmC) to another (CcmE). Here authors describe high resolution cryo-EM structures of CcmABCD in multiple states and propose a ...
Jiao Li, Wan Zheng, Ming Gu, Long Han, Yanmei Luo, Koukou Yu, Mengxin Sun, Yuliang Zong, Xiuxiu Ma, Bing Liu, Ethan P. Lowder, Deanna L. Mendez, Robert G. Kranz, Kai Zhang, Jiapeng Zhu   +14 more
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Treatment of COVID-19 by monoclonal antibodies and the traditional Chinese medicine

Medicine in Novel Technology and Devices, 2022
The mortality rate of the recent global pandemic corona virus disease 2019 (COVID-19) is currently as high as 7%. The SARS-CoV-2 virus is the culprit behind COVID-19.
Yuyan Ling, Yuxuan Dong, Qirui Li, Doudou Huang, Zhihui Li, Meijuan Chen   +5 more
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My perspective on Holistic integrative medicine

Journal of Holistic Integrative Pharmacy, 2020
Daiming FAN
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Aquaporin-9 facilitates liver regeneration following hepatectomy

Redox Biology, 2022
Aquaporin-9 (AQP9) is an aquaglyceroporin strongly expressed in the basolateral membrane of hepatocytes facing the sinusoids. AQP9 is permeable to hydrogen peroxide (H2O2) and glycerol as well as to water.
Bo Zhang, Dongyue Lv, Yang Chen, Weijue Nie, Yang Jiao, Junqi Zhang, Xiaoxiao Zhou, Xiao Wu, Siqing Chen, Tonghui Ma   +9 more
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Mechanism investigation of Caspase-8/GSDMC dependent immunogenic cell death induced by Ophiopogonin B in NSCLC cells

Pharmacological Research - Modern Chinese Medicine, 2022
Ophiopogonin B (OP-B) as a bioactive component of Radix Ophiopogon Japonicus has been reported to induce various kinds of cell death of non-small cell lung cancer (NSCLC) cells, while the underline mechanism is unknown.
Zhihui Li, Ling Gu, Qian Gao, Liqiu Li, Maozheng Sheng, Yuyan Ling, Cheng Hu, Menglin He, Xiongfei Zhang, Xu Shen, Xu Zhang, Meijuan Chen   +11 more
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Healing Emotions Through Philosophical Thinking [PDF]

, 2020
Manifesting in diverse forms, mental and emotional health problems within the contemporary society have proven challenging to current biomedical healing practice and thereby remain a significant threat to individuals ...
Um, Jeonghoon
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BUB1B and circBUB1B_544aa aggravate multiple myeloma malignancy through evoking chromosomal instability

Signal Transduction and Targeted Therapy, 2021
Multiple myeloma (MM) is an incurable plasma cell malignancy in the bone marrow characterized by chromosome instability (CIN), which contributes to the acquisition of heterogeneity, along with MM progression, drug resistance, and relapse.
Xiaozhu Tang, Mengjie guo, Pinggang Ding, Zhendong Deng, Mengying Ke, Yuxia Yuan, Yanyan Zhou, Zigen Lin, Muxi Li, Chunyan Gu, Xiaosong Gu, Ye Yang   +11 more
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Induction of Ferroptosis by Ophiopogonin-B Through Regulating the Gene Signature AURKA in NSCLC

Frontiers in Oncology, 2022
Ferroptosis is a new type of iron-dependent programmed cell death. In recent years, its role in the diagnosis and treatment of multiple tumors, including non-small cell lung cancer (NSCLC), has been continuously observed.
Liqiu Li, Liqiu Li, Qian Gao, Jin Wang, Ling Gu, Ling Gu, Zhihui Li, Shiping Zhang, Cheng Hu, Menglin He, Yulin Wang, Zixuan Wang, Yongxiang Yi, Jin Fu, Xiongfei Zhang, Fei Ge, Meijuan Chen, Xu Zhang   +17 more
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Discovery of the SHP2 allosteric inhibitor 2-((3R,4R)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)-5-(2,3-dichlorophenyl)-3-methylpyrrolo[2,1-f][1,2,4] triazin-4(3H)-one

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
The non-receptor protein tyrosine phosphatase (PTP) SHP2 encoded by the PTPN11 gene is a critical regulator in a number of cellular signalling processes and pathways, including the MAPK and the immune-inhibitory programmed cell death PD-L1/PD-1 pathway ...
Yanmei Luo, Jin Li, Yuliang Zong, Mengxin Sun, Wan Zheng, Jiapeng Zhu, Liu Liu, Bing Liu   +7 more
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HNRNPA2B1 promotes multiple myeloma progression by increasing AKT3 expression via m6A-dependent stabilization of ILF3 mRNA

Journal of Hematology & Oncology, 2021
N6-methyladenosine (m6A) modification is the most prevalent modification in eukaryotic RNAs while accumulating studies suggest that m6A aberrant expression plays an important role in cancer.
Fengjie Jiang, Xiaozhu Tang, Chao Tang, Zhen Hua, Mengying Ke, Chen Wang, Jiamin Zhao, Shengyao Gao, Artur Jurczyszyn, Siegfried Janz, Meral Beksac, Fenghuang Zhan, Chunyan Gu, Ye Yang   +13 more
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