Results 91 to 100 of about 89,718 (313)
The discovery of a site with abundant fossil plant remains in the surroundings of Aguilar de Campoo (Palencia, Spain), dated in the early Holocene, allowed us to obtain new data on the composition of foreste in that área. Two species of Pinus and several
Cristina Alcalde Olivares +5 more
doaj +1 more source
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Here we present a speleothem isotope record (POM2) from Ascunsă Cave (Romania) that provides new data on past climate changes in the Carpathian–Balkan region from 8.2 ka until the present.
Dragusin, Virgil +5 more
core +1 more source
THE STUDY OF LAKE ONEGO AND ITS DRAINAGE BASIN PALEOGEOGRAPHY USING A SET OF METHODS
The authors own and literary data on long-term paleogeographical research of Lake Onego and its drainage basin carried out using a set of methods are summarized in the article.
Lyudmila Filimonova, Nadezhda Lavrova
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Holocene relative sea-level reconstruction for the central great barrier reef, Australia: a subtidal foraminiferal approach [PDF]
Contemporary subtidal foraminiferal samples and associated environmental Information were collected from two embayments along the central Great Barrier Reef coastline, Australia, to comprehend the relationship of benthic foraminiferal assemblages with ...
Hardbattle, Michael Ian John
core
Anadolu Prehistoryasında Direkli Mağarası Kazıları ve Buluntuları
Anadolu arkeolojisinde mağara içi yerleşim ve kültürlerinin araştırılma tarihi çok eskilere dayanmaktadır. 1845 yılında Yarımburgaz Mağarası’nın, 1945 yılında Karain Mağarası’nın keşfinin ardından; on bir yıl sonra (1956) Öküzini Mağarası kazılarının ve ...
Cevdet Merih Erek, Sajad Samii
doaj
[Excerpt] He was always a modest man, but Ken was a genius and the toughest man we knew. He was also extraordinarily generous of spirit. The way he gave of himself, his time, and his hard-won stores of knowledge, was legendary amongst his friends and ...
Kristofer M. Helgen +2 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source

