Results 121 to 130 of about 293,402 (335)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

A Holocene paleoenvironmental record based on ungulate stable isotopes from Lukenya Hill, Kenya [PDF]

, 2019
Investigating the development of Holocene behavioral adaptations requires knowing how and why different human groups are distributed on the landscape. An expanded dataset of site-specific environmental and habitat reconstructions from eastern Africa are ...
Robinson, Joshua R.
core   +1 more source

Insight into the vegetation development of the Karkonosze Mountains (southwestern Poland) during the Late Vistulian and Holocene, based on data from glacial lakes

Acta Palaeobotanica
New palaeoecological records from two glacial lakes (the Mały Staw – 1183 m a.s.l. and the Wielki Staw – 1225 m a.s.l.) from the Polish Western Sudetes were obtained with the aim of better understanding the long-term vegetation development, the ...
Agnieszka Wacnik, Ewa Madeyska
doaj   +1 more source

Volcanic influence on centennial to millennial Holocene Greenland temperature change

Scientific Reports, 2017
Solar variability has been hypothesized to be a major driver of North Atlantic millennial-scale climate variations through the Holocene along with orbitally induced insolation change.
T. Kobashi, L. Menviel, A. Jeltsch-Thömmes, B. Vinther, J. Box, R. Muscheler, T. Nakaegawa, Patrik L Pfister, M. Döring, M. Leuenberger, H. Wanner, A. Ohmura   +11 more
semanticscholar   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Revealing the last 13,500 years of environmental history from the multiproxy record of a mountain lake (Lago Enol, northern Iberian Peninsula) [PDF]

, 2009
This is the author's accepted manuscript. The final publication is available at Springer via http://dx.doi.org/10.1007/s10933-009-9387-7.We present the Holocene sequence from Lago Enol (43°16′N, 4°59′W, 1,070 m a.s.l.), Cantabrian Mountains, northern ...
Ana Moreno, Lourdes López-Merino, Manel Leira, Javier Marco-Barba, Penélope González-Sampériz, Blas L. Valero-Garcés, José Antonio López-Sáez, Luisa Santos, Pilar Mata, Emi Ito, C Aguilar, JRM Allen, JRM Allen, RB Alley, JL Alonso, B Ammann, D Arobba, GG Bianchi, E Blanco-Castro, MA Blas Cortina, G Bond, G Bouchard, A Boyer-Klein, A Brauer, I Cacho, KE Camburn, JS Carrión, JS Carrión, JS Carrión, E Chapron, COHMAP, M Conedera, M Costa Tenorio, M Costa Tenorio, H Cremer, W Dansgaard, BAS Davis, L Abreu de, P deMenocal, GH Denton, S Desprat, D Domínguez-Villar, MB Edlund, K Faegri, M-A Fallu, P Farias, P Farias, WJ Fletcher, M García Antón, D Genty, C Goeury, P González-Sampériz, P González-Sampériz, P González-Sampériz, P González-Sampériz, EC Grimm, H Gurbuz, SP Harrison, E Heegaard, E Hernández Pacheco, G Jalut, M Jiménez Sánchez, S Juggins, HF Kleiven, S Kröpelin, H Lange-Bertalot, M Leira, A Leroi-Gourhan, P López, L López-Merino, MG Macklin, M Magny, M Magny, M Magny, M Magny, J Marquínez, F Martínez-Ruiz, C Martín-Puertas, PA Mayewski, J McManus, C Meisch, M Meléndez Asensio, S Mischke, J Montserrat, PD Moore, M Morellón, C Muñoz Sobrino, F Naughton, F Naughton, H Obermaier, SR O’Brien, MC Peñalba, R Pérez-Obiol, JM Punning, P Ramil Rego, P Ramil-Rego, PJ Reimer, J Renault-Miskovsky, I Renberg, S Riera, CN Roberts, JR Roca, JM Rubiales, MB Ruiz Zapata, MB Ruiz Zapata, L Santos, IR Smith, JP Smol, EF Stoermer, J Strockmarr, W Tinner, RM Trigo, JL Ubera, BL Valero-Garcés, B Geel van, B Geel van, B Geel van, B Geel van, B Geel van, JL Velasco, H Wanner, WA Watts, G Zanchetta   +122 more
core   +1 more source

Early-Holocene monsoon instability and climatic optimum recorded by Chinese stalagmites

The Holocene, 2019
The timing and duration of the Holocene East Asian summer monsoon (EASM) maximum and the interpretation of Chinese stalagmite δ18O records have long been disputed.
Xunlin Yang, Hong Yang, Hong Yang, Baoyan Wang, Li-Jung Huang, Chuan‐Chou Shen, R. Edwards, Hai Cheng, Hai Cheng   +8 more
semanticscholar   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Book review: From the Pleistocene to the Holocene

Journal of Lithic Studies, 2016
From the Pleistocene to the Holocene, edited by Bousman and Vierra, resets our thinking on the pace and overall patterns of transitions in North America at this time.
John Edward Dockall
doaj   +1 more source