Results 151 to 160 of about 293,402 (335)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

New determination of Pediastrum orientale in polar lake sediments and its palaeoecological implications – Reindeer Lake, Bellsund, Spitsbergen

Acta Palaeobotanica
The main component of microfossils in the bottom sediments of Reindeer Lake from Spitsbergen, documenting the almost 8,000-year history of this water body, are algae representing colonies of a very rare species Pediastrum orientale (Skuja) Jankovská et
Irena Agnieszka Pidek, Radosław Dobrowolski, Piotr Zagórski, Jan Rodzik, Edyta Łokas, Irka Hajdas   +5 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Sedimentary records of Holocene paleoflood events in the northern branch of the Daqing River

Dizhi lixue xuebao
Objective  The Haihe River Basin, located in the northern part of the North China Plain, within the semi-arid and semi-humid climatic region of north China, is a sensitive area for hydroclimatic changes and experiences frequent flood disasters ...
WANG Yong, WANG Yanjiao, YANG Jinsong, TIAN Fei, YUAN Lupeng   +4 more
doaj   +1 more source

Sea level and global ice volumes from the Last Glacial Maximum to the Holocene

Proceedings of the National Academy of Sciences of the United States of America, 2014
K. Lambeck, H. Rouby, A. Purcell, Yiying Sun, M. Sambridge   +4 more
semanticscholar   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Southern Arabia Population Patterns and Intensity of Cultural Exchanges Across the Holocene Humid Period

Open Quaternary
The Early and Middle Holocene (10,000–3,000 BCE) in Southern Arabia witnessed significant climate change and variation in material culture across space and time.
Maria Pia Maiorano, Eugenio Bortolini
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Floodplain environmental change during the younger dryas and holocene: Evidence from the lower kennet valley, south central England [PDF]

, 2006
Many lowland rivers across northwest Europe exhibit broadly similar behavioural responses to glacial-interglacial transitions and landscape development. Difficulties exist in assessing these, largely because the evidence from many rivers remains limited
Collins, PEF, Fenwick, IM, Keith-Lucas, DM, Worsley, P   +3 more
core  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source