Results 151 to 160 of about 1,234 (191)

The effect of parenteral vitamin B₁₂ treatment on its plasma metabolomic profile and on functional biomarkers of its deficiency. [PDF]

Sci Rep
Devi S, Pasanna RM, Ayoob F, Sachdev HS, Thomas T, Fiehn O, Kurpad AV.   +6 more
europepmc   +1 more source

Frequent use of zinc-containing denture adhesive can cause neurological trouble: a case of severe copper deficiency myeloneuropathy visible in T2w-STIR sequences of spinal MRI. [PDF]

BMC Neurol
Helmsen IC, Klietz M, Renne J, Wegner F.
europepmc   +1 more source

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Holotranscobalamin - a sensitive marker of cobalamin malabsorption

European Journal of Clinical Investigation, 1999
BackgroundNo simple and reliable method of identifying patients with cobalamin malabsorption is available at present. The measurement of plasma holotranscobalamin, i.e. the metabolically active cobalamins bound to the transport protein transcobalamin, has been suggested as a means of fulfilling such criteria.DesignWe describe a method that directly ...
Ebba Nexo, A Kilander
exaly   +3 more sources

Biological variation of holotranscobalamin and cobalamin in healthy individuals

Scandinavian Journal of Clinical and Laboratory Investigation, 2017
Data on biological variation for cobalamin and holotranscobalamin (holoTC) are limited. The aim of this study was to determine within-subject (CVI) and between-subject (CVG) biological variations for these analytes in a healthy population. We collected blood samples from 15 healthy volunteers (12 women and three men, 22-66 years) on the same weekday ...
Helle Borgstrøm Hager, Morten Lindberg
exaly   +3 more sources

Reference intervals and stability of haptocorrin and holotranscobalamin in Danish children and elderly

Clinica Chimica Acta, 2023
Haptocorrin (HC) and holotranscobalamin (holoTC) carry vitamin B12 (B12) in the circulation and can be useful biomarkers for evaluating B12 status. The concentration of both proteins depends on age, but data on reference intervals for children and the elderly are sparse.
Anders Abildgaard, Eva Greibe
exaly   +3 more sources

Homocysteine and holotranscobalamin and the risk of Alzheimer disease

Neurology, 2010
To examine the relation between serum levels of homocysteine (tHcy) and holotranscobalamin (holoTC), the active fraction of vitamin B12, and risk of incident Alzheimer disease (AD) in a sample of Finnish community-dwelling elderly.A dementia-free sample of 271 subjects aged 65-79 years derived from the Cardiovascular Risk Factors, Aging, and Dementia ...
B. Hooshmand, A. Solomon, I. Kareholt, J. Leiviska, M. Rusanen, S. Ahtiluoto, B. Winblad, T. Laatikainen, H. Soininen, M. Kivipelto   +9 more
openaire   +3 more sources

Evaluation of the technical performance of novel holotranscobalamin (holoTC) assays in a multicenter European demonstration project

Clinical Chemistry and Laboratory Medicine, 2005
A commercially available holotranscobalamin (holo-TC) radioimmunoassay (RIA) (Axis-Shield, Dundee, Scotland) was evaluated in four laboratories and compared with a holoTC ELISA run in one laboratory. The performance of the holoTC RIA assay was comparable
Ebba Nexo, Anne Molloy, Per Magne Ueland   +2 more
exaly   +2 more sources

Holotranscobalamin as a Predictor of Vitamin B12 Status

Clinical Chemistry and Laboratory Medicine, 2003
We report on the performance of a new test, holotranscobalamin, as compared to well established markers of vitamin B12 deficiency (plasma cobalamins, methylmalonic acid, and homocysteine). Holotranscobalamin was analyzed in 143 samples by a competitive radiobinding assay (Axis-Shield). Employing a cut-off value of 50 pmol/l, holotranscobalamin showed a
Anne-Mette, Hvas, Ebba, Nexo
openaire   +4 more sources

Holotranscobalamins in B12 and non B12 requiring prokaryotes and eukaryotes

Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 1996
Transcobalamins, vitamin B12 binding proteins, deliver B12 to cell surface receptors which then permit B12 to cross cell membranes for metabolic use. There is little documentation concerning B12 binding proteins in bacteria and protists. We found that prokaryotes and eukaryotes requiring B12, as well as those protists synthesizing B12, also produce ...
H, Baker, B, de Angelis, M, Khalil, O, Frank, E R, Baker   +4 more
openaire   +2 more sources