Results 161 to 170 of about 1,234 (191)

Holotranscobalamin Levels in Children with Helicobacter Pylori Infection

Helicobacter, 2015
AbstractBackgroundThe purpose of this study was to evaluate the association between vitamin B12 levels and Helicobacter Pylori infection and to examine the clinical usefulness of holotranscobalamin (holoTC) measurement in children.Materials and MethodsThirty patients between 6 and 15 years of age, who were diagnosed as H.
Oguz, Afyoncu, Orhan, Gursel, Avni, Atay, Emin, Kurekci, Necati, Balamtekin, Adnan, Hasimi, Mehmet A, Ozguven, Okan, Ozcan   +7 more
openaire   +2 more sources

Performance Characteristics of the ARCHITECT Active-B12 (Holotranscobalamin) Assay

Clinical Laboratory, 2015
Vitamin B12 (cobalamin) is a necessary cofactor in methionine and succinyl-CoA metabolism. Studies estimate the deficiency prevalence as high as 30% in the elderly population. Ten to thirty percent of circulating cobalamin is bound to transcobalamin (holotranscobalamin, holoTC) which can readily enter cells and is therefore considered the bioactive ...
Stephen D, Merrigan, William E, Owen, Joely A, Straseski   +2 more
openaire   +2 more sources

Chemotherapy-induced suppression of serum holotranscobalamin

Journal of Clinical Oncology, 2009
e20639 Purpose: Chemotherapy-induced damage to the stomach and small intestine may inhibit the absorption of vitamin B12. To assess the risk of chemotherapy causing acute vitamin B12 deficiency, we primarily measured the active form of vitamin B12, holotranscobalamin, but also total serum B12, methylmalonic acid, and total homocysteine.
G. Tisman, S. J. Kutik, Y. A. Khan
openaire   +1 more source

The relationship of leukocyte anisocytosis to holotranscobalamin, a marker of cobalamin deficiency

International Journal of Laboratory Hematology, 2011
SummaryIntroduction:  After measurement of the mean volumes of leukocyte subpopulations as well as the distribution widths (DW) of these volumes has become available, we investigated whether such morphometric leukocyte parameters are associated with a commonly used marker of cobalamin deficiency, i.e., holotranscobalamin (HoloTC).
C, Risch, P, Medina, U E, Nydegger, Z, Bahador, T, Brinkmann, P, Von Landenberg, M, Risch, L, Risch   +7 more
openaire   +2 more sources

CLINICAL USEFULNESS OF HOLOTRANSCOBALAMIN MEASUREMENT

Clinical chemistry and laboratory medicine, 2008
The aim of this study was to assess clinical usefulness of holotranscobalamin measurement.
Mandić, Sanja, Horvat, Vesna, Mandić, Dario, Majetić-Cetina, Neda   +3 more
openaire   +2 more sources

Frequency of Combined Deficiencies of Vitamin D and Holotranscobalamin in Cancer Patients

Nutrition and Cancer, 2004
Abstract Low serum levels of vitamin D are associated with a higher frequency of at least eleven different malignancies including breast, colon, and prostate cancer (Holick, M.F. Vitamin D: Millenium Perspective. Journal of Cellular Biochemistry. 2003. 88:296–307).
Ashley Serene, Plant, Glenn, Tisman
openaire   +2 more sources

Functional Vitamin B12 Deficiency and Determination of Holotranscobalamin in Populations at Risk

Clinical Chemistry and Laboratory Medicine, 2003
The prevalence of a sub-clinical functional vitamin B12 deficiency in the general population is higher than previously expected. Total serum vitamin B12 may not reliably indicate vitamin B12 status. To get more specificity and sensitivity in diagnosing vitamin B12 deficiency, the concept of measuring holotranscobalamin II (holoTC), a sub-fraction of ...
Wolfgang, Herrmann, Rima, Obeid, Heike, Schorr, Jürgen, Geisel   +3 more
openaire   +2 more sources

COBALAMIN AND HOLOTRANSCOBALAMIN IN HUMAN SEMINAL FLUID

Clinical chemistry and laboratory medicine, 2009
Background: Some recent study supports the role of cobalamin in spermatogenesis and correlation with several sperm parameters. Cobalamin (vitamin B12) is bound to two proteins, transcobalamin and haptocorrin. Holotranscobalamin (also known as active B12 or holo-TC) is a metabolically active form of cobalamin, and this parameter showed promising results
Mandić, Sanja, Majetić-Cetina, Neda, Debeljak, Željko, Horvat, Vesna, Mandić, Dario   +4 more
openaire   +1 more source

Comparability and Stability of Holotranscobalamin levels in Capillary and Venous Blood

2023
Abstract Introduction Self-collected capillary blood has numerous advantages over venous samples taken via phlebotomy, as such the use of this finger-prick testing has increased over recent years, driven in some part by Covid antibody testing.
Timothy Woolley, Emma Rutter, Macarena Staudenmaier   +2 more
openaire   +1 more source

The Usefulness of Holotranscobalamin in Predicting Vitamin B12 Status in Different Clinical Settings

Current Drug Metabolism, 2005
Serum concentrations of homocysteine (Hcy) and methylmalonic acid (MMA) become increased in B12-deficient subjects and are therefore, considered specific markers of B12 deficiency. Serum level of holotranscobalamin (holoTC) becomes decreased before the development of the metabolic dysfunction.
Wolfgang, Herrmann, Rima, Obeid, Heike, Schorr, Jürgen, Geisel   +3 more
openaire   +2 more sources