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Front-line Nursing Home Staff Experiences During the COVID-19 Pandemic
Journal of the American Medical Directors Association, 2020 Objective The Coronavirus disease 2019 (COVID-19) pandemic is an unprecedented challenge for nursing homes, where staff have faced rapidly evolving circumstances to care for a vulnerable resident population.
Elizabeth M White +3 more
semanticscholar +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Survey of the Demands of End Users in Europe for Organic Market Data [PDF]
, 2013 Few European countries produce complete coverage of important market data, standardization is missing, and data are seldom comparable within one country over time and between countries. Furthermore, detailed information on specific commodities is missing.
Home, Robert +2 more
core
The experiences of early childhood development home visitors in the Eastern Cape province of South Africa [PDF]
, 2019 BACKGROUND This article examines the development of early childhood development (ECD) home-visiting services in South Africa. AIM To examine the factors that could support the success of home-visiting programmes as well as to explore the ...
Azzi-Lessing, Lenette, Schmidt, Kim
core +1 more source
Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells
FEBS Letters, EarlyView.Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López +2 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Built Space Hinders Lived Space: Social Encounters and Appropriation in Large Housing Estates
Urban Planning, 2023 The fundamental structural, demographic, and socio-economic changes afflicting large housing estates in Eastern German cities raise questions about how these neighborhoods could be maintained and developed into attractive residential locations where ...
Katja Friedrich, Stefanie Rößler
doaj +1 more source
Work from Home After the COVID-19 Outbreak
Federal Reserve Bank of Dallas, Working Papers, 2020 Based on rich novel survey data, we document that 35.2 percent of the US workforce worked entirely from home in May 2020, up from 8.2 percent in February.
Alexander Bick +2 more
semanticscholar +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source