Results 91 to 100 of about 4,469,958 (240)
Advanced Science, EarlyView.Microglial PBRM1 deficiency drives excessive hippocampal neurogenesis by enhancing CCL5–CCR1/5 signaling, leading to autism‐like behaviors. A pro‐inflammatory IL1α+/TNFα+ microglial subset is identified as a key cellular contributor to this process. PBRM1 represses Ccl5 expression at the transcriptional level.
Yang‐Yang Duan +12 more
wiley +1 more source
Optimizing Operations with Home Cage Monitoring in Animal Facilities
Abstract Operational efficiency is a critical determinant of success in laboratory animal facilities, shaping financial sustainability, research quality, and the well-being of both staff and animals. This chapter focuses on how home cage monitoring (HCM) systems can serve as a central driver of efficiency when integrated thoughtfully ...
James Bussell +4 more
openaire +1 more source
Advanced Science, EarlyView.Oral exposure to cannabis‐associated Actinomyces species, particularly A. meyeri, is associated with anxiety‐like behavior in mice in the absence of detectable bacterial translocation or overt systemic inflammation. These findings support a potential oral‐brain metabolic axis involving candidate metabolites such as arginine and argininosuccinate ...
Tabinda Salman +11 more
wiley +1 more source
Study Design and Data Analysis in Home Cage Monitoring Experiments
Abstract Home cage monitoring (HCM) represents a paradigm shift in rodent behavioural research, replacing brief manual observations with continuous digital surveillance that captures animal behaviour in its natural context. This technological revolution generates vast amounts of data, offering both unprecedented opportunities and ...
Reid D. Landes +2 more
openaire +1 more source
Home-cage behavior after seizure remission and anticonvulsant treatment.
, 2019 Two months after the cessation of daily injections, mice were reintroduced into home-cage monitoring chambers. (B) Overall distances moved between previously saline (n = 12) and PTZ-treated (n = 17) mice were no different (group x hour, F19,513 = 0.44, p>
Vaishnav Krishnan (7832624) +2 more
core +1 more source
Targeted Mechanogenetics to Modulate Specific Deep Neural Circuits
Advanced Science, EarlyView.This study introduces mechanogenetics, a nanobubble‐enhanced sonogenetic strategy for selective modulation of feeding‐related neural circuits in the mouse lateral hypothalamus. Mechanogenetic stimulation modulates feeding behavior through glutamatergic projections from the lateral hypothalamus to the ventral tegmental area, highlighting its potential ...
Xuandi Hou +3 more
wiley +1 more source
Advanced Science, EarlyView.RCI is associated with functional suppression of oxytocinergic neurons in the PVN. Reduced PVNOXT neuronal activity contributes to altered sympathetic regulation involving the IML–sympathetic chain pathway, accompanied by changes in norepinephrine signaling at the BTI.
Liyang Wan +8 more
wiley +1 more source
Molecular Rectification: Mechanisms, Modulation Strategies, and Device Realization
Advanced Science, EarlyView.This review focuses on molecular rectification, from its fundamental mechanisms and modulation strategies to device realization. It summarizes the theoretical framework, modulation strategies, fabrication techniques, characterization methods, and modeling and simulation of molecular rectifiers, while discussing challenges and future directions for ...
Junnan Guo +8 more
wiley +1 more source
Remote Control and Monitoring of Smart Home Facilities via Smartphone with Wi-Fly [PDF]
, 2015 Due to the widespread ownership of smartphone devices, the application of mobile technologies to enhance the monitoring and control of smart home facilities has attracted much academic attention.
Lu, Joan, Ghabar, Omar
core +1 more source