Results 101 to 110 of about 4,469,958 (240)

Advancing Biotherapeutic Treatment of Ulcerative Colitis Using Lipid Mesophases: Formulation Design and Preclinical Validation

Advanced Science, EarlyView.
Lipid mesophases provide a versatile platform for colon‐targeted delivery of biotherapeutics, protecting them from degradation while enhancing mucoadhesion and enabling localized, controlled release to the inflamed mucosa after oral or rectal administration. In a DSS‐induced colitis model, this strategy reduced disease activity, inflammatory biomarkers,
Rafaela Gazzi, Tiziana Cremona, Reto Czekalla, Emily Campbell, Marlene Schwarzfischer, Doris Pöhlmann, Vanessa Dobernig, Gerhard Rogler, Michael Scharl, Alessandra Bergadano, Raffaele Mezzenga, Martin Kuentz, Paola Luciani, Simone Aleandri   +13 more
wiley   +1 more source

Hypothalamic POMC Neurons Gate the Fear‐Feeding Trade‐Off

Advanced Science, EarlyView.
Hungry animals must continually arbitrate between feeding and defensive behaviors when confronted with potential threats. We show that hypothalamic POMC neurons engage CRH‐expressing stress circuits and downstream hormonal responses to coordinate this behavioral selection between competing behaviors.
Cristina Miralpeix, Abel Eraso‐Pichot, Vincent Simon, Victor Jouque, Melissa Sadallah, Samantha Clark, Philippe Zizzari, Urszula Skupio, Ana Covelo, Nathalie Dupuy, Jean Charles Nicolas, Astrid Cannich, Thierry Leste‐Lasserre, Guillaume Laplagne, Carmelo Quarta, Giovanni Marsicano, Daniela Cota   +16 more
wiley   +1 more source

Astrocytic Ketogenesis Protects Central Nervous System Injury via CPT1A Stabilization and Epigenetic Regulation

Advanced Science, EarlyView.
A distinct astrocyte subpopulation, enriched at the lesion border, drives CNS repair through enhanced ketone body metabolism. This process promotes neuronal survival and axonal sparing via CPT1A stabilization and H3K9bhb‐dependent epigenetic reprogramming, positioning astrocytic ketogenesis as a promising therapeutic target for tissue regeneration ...
Dishui Pan, Haoming Shu, Rui Gao, Yilong Ren, Wu Ye, Xuhui Ge, Yao Gu, Yufeng Zhu, Xiaokun Wang, Honglin Teng, Xuhui Zhou, Wei Liu, Yang Gao, Jianquan Zhao, Weihua Cai   +14 more
wiley   +1 more source

Home Cage Monitoring in Pharmaceutical Industries and Contract Research Organizations

Abstract Home cage monitoring (HCM) systems enable continuous, automated observation of laboratory animals in their standard environment without human interference and are aligned with the 3Rs principle (reduction, refinement, replacement).
Gommet Céline, Marcel M. van Gaalen, Scorrano Fabrizio   +2 more
openaire   +1 more source

24-Hour Home Cage Activity Monitoring in Mice v1

This protocol describes the assessment of spontaneous 24-hour home cage activity in adult mice using infrared beam-break technology. Beam crossings are used as a continuous, non-invasive indicator of horizontal locomotion across the full light–dark cycle.
Sarah van Veen, Zsuzsanna Callaerts-Végh   +1 more
openaire   +1 more source

A Programmable Braided Silk‐Glass Fiber Ligament Promoting Rapid Motoric Recovery

Advanced Science, EarlyView.
A scalable three‐dimensional braiding strategy integrates silk and glass fibers into customizable artificial ligaments with programmable “J‐shaped” nonlinear mechanics. The silk‐rich architecture supports osseoligamentous integration, while glass fibers provide mechanical reinforcement and biomimetic mineralization cues, enabling strain‐adaptive load ...
Changbo Lu, Daming Liu, Haoxin Zhang, Zhiwei Qiao, Qiuming Gao, Jia Meng, Hongyin Yue, Songkai Li, Shuo Zhang, Tao Yuan, Yun Xue, Hui Jiang, Zhenguo Liu, Yibo Wang, Nirong Bao, Yuli Chen, Xiaojiang Yang   +16 more
wiley   +1 more source

Education and Training School in Home Cage Monitoring: The ‘Whys’ and ‘Hows’

Abstract The adoption of Home Cage Monitoring (HCM) systems, as well as its effective and ethical use, requires proper education and training in this technology. This chapter explores the critical role of training in preparing researchers to handle the complexities associated with HCM.
Nuno Henrique Franco, Silvia Mandillo, Lior Bikovski   +2 more
openaire   +1 more source

Engineered Chiral Probiotics Ameliorate MASH via Gut–Liver Axis

Advanced Science, EarlyView.
A chiral gold nanozyme was coated onto the gut commensal bacterium Faecalibacterium duncaniae (F. duncaniae) to create an engineered probiotic. In mouse models of MASH, this orally administered living therapeutic protected the bacterium against oxidative stress, enhanced its gut colonization, reversed steatosis, inflammation, and fibrosis, and improved
Jing Chen, Shen Zhang, Yuli Zhu, Da Zhou, Chunya Ji, Mingrui Zhu, Sirui Wang, Yuting Shen, Jifeng Yu, Heng Zhang, Yan Fang, Huixiong Xu, Haohao Yin   +12 more
wiley   +1 more source

Commercializing Home Cage Monitoring: From Prototype to Global Access

Abstract Even the greatest invention is useless if it does not become widely accessible. This chapter presents a practical framework for commercializing and scaling automated home cage monitoring (HCM) systems used in laboratory animal research.
Michael Florea, Noah Weber, Christopher K. Adams, John Lighton, Robbin Turner, Matt Ruiter, Stefano Gaburro   +6 more
openaire   +1 more source

Cage fish culture in Nepal [PDF]

, 1979
This paper describes briefly cage fish culture in Nepal with reference to (1) the construction and design of cages; (2) the species used; (3) cage culture practices and results; (4) the economics of cage ...
Sharma, Rama Nath
core   +1 more source