Results 171 to 180 of about 4,469,958 (240)

The dual incretin agonist tirzepatide blunts nicotine‐induced behaviours and neurochemistry in male mice

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Nicotine dependence remains one of the leading causes of morbidity and mortality worldwide, with high relapse rates and post‐cessation weight gain representing persistent barriers to sustained abstinence. The incretin hormones glucose‐dependent insulinotropic polypeptide (GIP) and glucagon‐like peptide‐1 (GLP‐1) have ...
Christian E. Edvardsson, Thaynnam A. Emous, Sarah Witley, Mia Ericson, Louise Adermark, Elisabet Jerlhag   +5 more
wiley   +1 more source

Effects of lifelong sulforaphane intake on behavioural, neurochemical and biomolecular dysfunctions in the BTBR T+ Itpr3tf/J mouse model of autism spectrum disorders

British Journal of Pharmacology, EarlyView.
Created in BioRender. Schiavone, S. (2026). https://BioRender.com/cy0xq6z. Abstract Background and Purpose Autism spectrum disorders (ASD) are multifactorial neurodevelopmental conditions associated with oxidative stress and neuroinflammation across critical developmental periods.
Vladyslav Sikora, Maria Bove, Lisa Pia Agosti, Rossella Pia Palmieri, Mohsin Zafar, Paolo Tucci, Maria Grazia Morgese, Stefania Schiavone, Luigia Trabace   +8 more
wiley   +1 more source

Cholinergic inputs to motoneurons in the spinal cord augment focal muscle spasticity in rodents

British Journal of Pharmacology, EarlyView.
Background and Purpose Cholinergic premotor inputs to motoneurons support high levels of motor output when required. However, the possible role of these inputs in pathologically elevated muscle tone has not been characterised. To address this, we examined the modulatory effect of spinal acetylcholine (ACh) on experimental spastic paralysis ...
Patrik Meglić, Petra Šoštarić, Eirini Tsape, Melpomeni Galani, Ana Knezović, Laura Restani, Marco Pirazzini, Ornella Rossetto, Gareth B. Miles, Laskaro Zagoraiou, Ivica Matak   +10 more
wiley   +1 more source

Highly potent, brain‐penetrant EP2 receptor antagonists for the treatment of permanent focal cerebral ischaemia in male and female mice

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Cerebral ischaemia is a leading cause of death in older adults and imposes a substantial global economic burden. Recent studies indicate that inhibiting the Gαs‐coupled EP2 receptor reduces ischaemic brain injury by modulating neuroinflammation.
Zhen Jin, Chenyao Jiang, Eun Bee Cho, M. Dennis Leo, Jiukuan Hao, Jiawang Liu, Ying Yu, Jianxiong Jiang   +7 more
wiley   +1 more source

Advancing conservation breeding programs for marine invertebrates

Conservation Biology, EarlyView.
Abstract In the face of ecosystem change and biodiversity loss caused by climate change and other stressors, conservation breeding, or captive breeding, with the aim of reintroduction for wild population recovery, is an emerging tool for preventing species’ extinction and rehabilitating ecosystems.
Elora H. López‐Nandam, Bart Shepherd, Kylie Lev, Rebecca Albright   +3 more
wiley   +1 more source

Digital Food Purchase Signatures and Their Response to GLP‐1‐Based Treatment in People With Obesity

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims To characterise digital food purchase signatures in adults with obesity (OB) versus normal‐weight (NW) controls and explore changes from pre‐treatment to early (5‐month) and later (10‐month) phases of glucagon‐like peptide‐1 receptor agonist (GLP‐1RA) therapy, including high and low weight‐loss responders.
Freya Orban, Laura Fernandez Cerro, Melanie Stoll, Maurice Rupp, David Herzig, Lia Bally   +5 more
wiley   +1 more source

Exploiting Native Biodiversity for Invasive Species Management: The Case of Exorista larvarum as a Natural Enemy of the Invasive Box Tree Moth Cydalima perspectalis

Entomologia Experimentalis et Applicata, EarlyView.
The investigations evaluated the performance of the native parasitoid Exorista larvarum (L.) on last instar Cydalima perspectalis (Walker) larvae, using the factitious host Galleria mellonella (L.) as a control. Laboratory bioassays were conducted using no‐choice and choice (1:1 and 5:5) experimental designs.
Serena Gallizia, Santolo Francati, Maria Luisa Dindo, Chiara Ferracini   +3 more
wiley   +1 more source

Blacklegged Ticks, Ixodes scapularis, Respond to Sex‐Attractant Semiochemicals of Male Deer Mice, Peromyscus maniculatus

Entomologia Experimentalis et Applicata, EarlyView.
Ticks are obligate ectoparasites that blood‐feed on a variety of vertebrate hosts including rodents such as deer mice, Peromyscus maniculatus bairdii. Female blacklegged ticks, Ixodes scapularis—but not female lone star ticks, Amblyomma americanum, or American dog ticks, Dermacentor variabilis—were attracted to urine‐ and feces‐soiled bedding of male ...
Claire E. Gooding, Sauleha Yaqub, Layla Gould, Regine Gries, Gerhard Gries   +4 more
wiley   +1 more source

A live‐cell autophagy reporter reveals reversible vacuolation in naked mole‐rat skin fibroblasts under lysosomal stress

The FEBS Journal, EarlyView.
A tandem fluorescent mCherry–EGFP–LC3 reporter enables live‐cell visualisation of autophagy–lysosome dynamics in naked mole‐rat skin fibroblasts. Chloroquine‐induced lysosomal stress promotes accumulation of neutral LC3‐positive compartments and triggers pronounced LC3‐associated vacuolation.
Fangze Tong, Mateo P. Hoare, Laura J. Grundy, Filomena Gallo, Karin H. Müller, Ewan St. John Smith, Janet R. Kumita   +6 more
wiley   +1 more source

Conifer host identity shapes wood‐boring beetle communities more than climate across a latitudinal forest gradient in Quebec (Canada)

Insect Conservation and Diversity, EarlyView.
Host tree identity and latitude shaped wood‐boring beetle assemblages, with species richness declining northward but community composition varying among regions and hosts. Host tree species influenced beetle communities more strongly than climate; black spruce supported the most species, while eastern hemlock hosted very few.
Nicolas Perrault, Emilie Champagne, Mathieu Bouchard   +2 more
wiley   +1 more source