Results 51 to 60 of about 837,191 (303)

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Komunikasi Interpersonal Perawat dengan Lansia Panti Jompo Upt Pstw Khusnul Khotimah di Kota Pekanbaru [PDF]

, 2014
Interpersonal communication is very important in the interaction of a goodrelationship between the nurse with the elderly in a nursing home. Through interpersonalcommunication can nurses know how to build a good relationship with the elderly, causing ...
Havifi, I. (Ilham), Wirman, W. (Welly)
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Declines in Activities in Daily Living of Older Adults with Sarcopenia Were Associated with Gait Speed

Medicina
Background and Objectives: Early assessment interventions are recommended for older adults with sarcopenia. Gait speed in older adults considerably decreases activities of daily living (ADL).
Ryo Sato, Yohei Sawaya, Tamaki Hirose, Takahiro Shiba, Lu Yin, Shuntaro Tsuji, Masahiro Ishizaka, Tomohiko Urano   +7 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Oral symptoms in dying nursing home patients. Results from the prospective REDIC study

BMC Oral Health
Background The mouth is a central organ for communication and fluid intake, also for dying nursing home patients. This study describes the prevalence and severity of oral symptoms from nursing home admission until the day of perceived dying and the day ...
Reidun K. N.M. Sandvik, Bettina S. Husebo, Geir Selbaek, Gunhild Strand, Monica Patrascu, Manal Mustafa, Sverre Bergh   +6 more
doaj   +1 more source

Home Accidents in the Elderly in Turkey

The Tohoku Journal of Experimental Medicine, 2006
Houses may accommodate environmental barriers that pose a risk for older people. This study aimed to identify the main characteristics of the dwellings of the elderly, and to assess the impact of those on home accidents. In that cross-sectional study, 3,277 people over 60 years of age living in Aydin province of Turkey were evaluated in December 2004 ...
E Didem, Evci, Filiz, Ergin, Erdal, Beşer   +2 more
openaire   +2 more sources

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Physical activity intervention for elderly patients with reduced physical performance after acute coronary syndrome (HULK study): Rationale and design of a randomized clinical trial [PDF]

, 2018
Background: Reduced physical performance and impaired mobility are common in elderly patients after acute coronary syndrome (ACS) and they represent independent risk factors for disability, morbidity, hospital readmission and mortality.
Biscaglia, Simone, Bugani, Giulia, Campo, Gianluca, Chiaranda, Giorgio, Corvi, Ursula, Ferrari, Roberto, Grazzi, Giovanni, Lucchi, Giulia Ricci, Maietti, Elisa, Mazzoni, Gianni, Myers, Jonathan, Pasanisi, Giovanni, Pavasini, Rita, Ruggiero, Rossella, Sella, Gianluigi, Serenelli, Matteo, Tonet, Elisabetta, Villani, Giovanni Quinto, Vitali, Francesco, Volpato, Stefano   +19 more
core   +2 more sources