Results 161 to 170 of about 45,307 (198)
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1998
Abstract As described in Chapter 3, homeodomain proteins are transcription factors that are characterized by the presence of a 60-amino-acid DNA binding domain. The structure of the homeodomain consists of a flexible amino-terminal arm followed by three a helices (Fig.
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Abstract As described in Chapter 3, homeodomain proteins are transcription factors that are characterized by the presence of a 60-amino-acid DNA binding domain. The structure of the homeodomain consists of a flexible amino-terminal arm followed by three a helices (Fig.
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Target genes of homeodomain proteins
BioEssays, 1999Homeodomain proteins are transcription factors that share a related DNA binding domain, the homeodomain. This class of proteins was first recognized in the fruitfly Drosophila melanogaster where they cause homeotic transformations such as a fly with four wings instead of two (Lewis EB. A gene complex controlling segmentation in Drosophila.
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Biochemistry, 2000
The mating type homeodomain proteins, MATa1 and MATalpha2, combine to form a heterodimer to bind DNA in diploid yeast cells. The a1-alpha2 heterodimer tightly and specifically binds haploid-specific gene operators to repress transcription. On its own, however, the a1 homeodomain does not bind DNA in a sequence-specific manner.
J S, Anderson +4 more
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The mating type homeodomain proteins, MATa1 and MATalpha2, combine to form a heterodimer to bind DNA in diploid yeast cells. The a1-alpha2 heterodimer tightly and specifically binds haploid-specific gene operators to repress transcription. On its own, however, the a1 homeodomain does not bind DNA in a sequence-specific manner.
J S, Anderson +4 more
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Homeodomain Determinants of Major Groove Recognition
Biochemistry, 1994The homeodomain is a highly conserved structural module that binds DNA and participates in protein-protein interactions. Most homeodomains contain residues at positions 47 and 51 which mediate recognition of a TAAT core binding sequence in the major groove.
J L, Pomerantz, P A, Sharp
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Homeodomain Subtypes and Functional Diversity
2011The homeodomain is a protein domain of about 60 amino acids that is encoded by homeobox genes. The homeodomain is a DNA binding domain, and hence homeodomain proteins are essentially transcription factors (TFs). They have been shown to play major roles in many developmental processes of animals, as well as fungi and plants.
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Current Opinion in Structural Biology, 1994
Abstract Transcription factors containing homeodomain and POU domain DNA-binding motifs play central developmental roles in eukaryotes. Over the past year, considerable progress has been made in the structural characterization of these domains and in elucidating the factors that determine sequence-specific DNA recognition.
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Abstract Transcription factors containing homeodomain and POU domain DNA-binding motifs play central developmental roles in eukaryotes. Over the past year, considerable progress has been made in the structural characterization of these domains and in elucidating the factors that determine sequence-specific DNA recognition.
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The structure and function of the homeodomain
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1989M P, Scott, J W, Tamkun, G W, Hartzell
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