Fusion Gene KMT2A::SEPTIN6 in Acute Myeloid Leukemia Cell Line KOPM-88 [PDF]
Cells(1) Background: KMT2A (alias MLL) is located at chromosome 11q23 and encodes histone methyltransferase 2A which activates target genes via chromatin methylation of histone H3 lysine K4.
Stefan Nagel +7 more
doaj +2 more sources
Widespread employment of conserved C. elegans homeobox genes in neuronal identity specification
PLoS Genetics, 2022 Homeobox genes are prominent regulators of neuronal identity, but the extent to which their function has been probed in animal nervous systems remains limited.
Jayson Smith +2 more
exaly +4 more sources
Genome-Wide Analysis of Homeobox Gene Family in Legumes: Identification, Gene Duplication and Expression Profiling [PDF]
PLoS ONE, 2015 Homeobox genes encode transcription factors that are known to play a major role in different aspects of plant growth and development. In the present study, we identified homeobox genes belonging to 14 different classes in five legume species, including ...
Rohini Garg, Mukesh Jain, Rajesh Ghangal
exaly +2 more sources
The Homeobox Genes of Caenorhabditis elegans and Insights into Their Spatio-Temporal Expression Dynamics during Embryogenesis [PDF]
PLoS ONE, 2015 Homeobox genes play crucial roles for the development of multicellular eukaryotes. We have generated a revised list of all homeobox genes for Caenorhabditis elegans and provide a nomenclature for the previously unnamed ones.
Johan Henriksson +2 more
exaly +2 more sources
The Homeobox Genes: Classification, Regulation, Biological Functions, and Diseases [PDF]
MedCommHomeobox genes constitute a large family of transcription factors that act as master regulators involved in multiple fundamental processes such as development and cell differentiation.
Maedeh Dadzadi +5 more
doaj +2 more sources
eLife, 2021 Neuronal cell fate determinants establish the identities of neurons by controlling gene expression to regulate neuronal morphology and synaptic connectivity.
Mizuki Kurashina +5 more
doaj +1 more source
Identification of Novel Genetic Variants Related to Trabecular Bone Score in Community-Dwelling Older Adults [PDF]
Endocrinology and Metabolism, 2020 Background As the genetic variants of trabecular bone microarchitecture are not well-understood, we performed a genome-wide association study to identify genetic determinants of bone microarchitecture analyzed by trabecular bone score (TBS).
Sung Hye Kong +8 more
doaj +1 more source
Genetic Regulation of Vertebrate Forebrain Development by Homeobox Genes
Frontiers in Neuroscience, 2022 Forebrain development in vertebrates is regulated by transcription factors encoded by homeobox, bHLH and forkhead gene families throughout the progressive and overlapping stages of neural induction and patterning, regional specification and generation of
Ryan F. Leung +12 more
doaj +1 more source
HOXA Amplification Defines a Genetically Distinct Subset of Angiosarcomas
Biomolecules, 2022 Angiosarcoma is a rare, devastating malignancy with few curative options for disseminated disease. We analyzed a recently published genomic data set of 48 angiosarcomas and noticed recurrent amplifications of HOXA-cluster genes in 33% of patients.
Hongbo M. Xie, Kathrin M. Bernt
doaj +1 more source
Tropical and Subtropical Agroecosystems, 2023 Background: During the last few years the home box transcription factor WUSCHEL (WUS) has been shown to cause dedifferentiation when expressed on somatic cells followed by a production of new stem cells that can lead to somatic embryogenesis or ...
Ana Ly Arroyo Herrera +7 more
doaj +1 more source