Results 41 to 50 of about 82,771 (160)

The impact of glutamine deprivation on the expression of MEIS3, SPAG4, LHX1, LHX2, and LHX6 genes in ERN1 knockdown U87 glioma cells

Endocrine Regulations, 2022
Objective. The aim of the current study was to investigate the expression of genes encoded homeobox proteins such as MEIS3 (Meis homeobox 3), SPAG4 (sperm associated antigen 4), LHX1 (LIM homeobox 1), LHX2, and LHX6 in U87 glioma cells in response to ...
Krasnytska Dariia A., Khita Olena O., Tsymbal Dariia O., Luzina Olha Y., Cherednychenko Anastasiia A., Kozynkevich Halyna E., Bezrodny Borys H., Minchenko Dmytro O.   +7 more
doaj   +1 more source

Modification of Lhx2 activity for ex vivo amplification of human iPSC-derived hematopoietic stem/progenitor cells

Frontiers in Cell and Developmental Biology
Hematopoietic stem cells (HSCs) obtained from patient-derived human induced pluripotent stem cells (iPSCs) are a promising tool for curing various hematological disorders.
Kenji Kitajima, Yuna Takahashi, Yuna Takahashi, Hikaru Ando, Hikaru Ando, Minako Shingai, Minako Shingai, Mako Hamasaki, Mako Hamasaki, Miyu Tanikawa, Miyu Tanikawa, Mai Kanokoda, Mai Kanokoda, Marino Nakajima, Marino Nakajima, Yasumasa Nishito, Takahiko Hara, Takahiko Hara, Takahiko Hara   +18 more
doaj   +1 more source

Aberrant Expression and Oncogenic Activity of SPP1 in Hodgkin Lymphoma

Biomedicines
Background: Hodgkin lymphoma (HL) is a B-cell-derived malignancy and one of the most frequent types of lymphoma. The tumour cells typically exhibit multiple genomic alterations together with aberrantly activated signalling pathways, driven by paracrine ...
Stefan Nagel, Corinna Meyer
doaj   +1 more source

Identification and characterization of homeobox genes in Eucalyptus

Genetics and Molecular Biology, 2005
Homeobox genes encode transcriptional factors, usually involved in molecular control of plant developmental patterns. They can be divided into several classes according to conserved sequences within the homeobox region and the presence of specific ...
Graça Celeste Gomes Rocha, Régis Lopes Corrêa, Anna Cristina Neves Borges, Claudio Bustamante Pereira de Sá, Márcio Alves-Ferreira   +4 more
doaj   +1 more source

An Orthologous Epigenetic Gene Expression Signature Derived from Differentiating Embryonic Stem Cells Identifies Regulators of Cardiogenesis. [PDF]

PLoS ONE, 2015
Here we used predictive gene expression signatures within a multi-species framework to identify the genes that underlie cardiac cell fate decisions in differentiating embryonic stem cells.
Brian W Busser, Yongshun Lin, Yanqin Yang, Jun Zhu, Guokai Chen, Alan M Michelson   +5 more
doaj   +1 more source

The dynamics of vertebrate homeobox gene evolution: gain and loss of genes in mouse and human lineages

BMC Evolutionary Biology, 2011
Background Homeobox genes are a large and diverse group of genes, many of which play important roles in transcriptional regulation during embryonic development.
Holland Peter WH, Zhong Ying-fu
doaj   +1 more source

Reconstruction of ancient homeobox gene linkages inferred from a new high-quality assembly of the Hong Kong oyster (Magallana hongkongensis) genome

BMC Genomics, 2020
Background Homeobox-containing genes encode crucial transcription factors involved in animal, plant and fungal development, and changes to homeobox genes have been linked to the evolution of novel body plans and morphologies.
Yiqian Li, Wenyan Nong, Tobias Baril, Ho Yin Yip, Thomas Swale, Alexander Hayward, David E. K. Ferrier, Jerome H. L. Hui   +7 more
doaj   +1 more source

Evolution of homeobox genes

WIREs Developmental Biology, 2012
AbstractMany homeobox genes encode transcription factors with regulatory roles in animal and plant development. Homeobox genes are found in almost all eukaryotes, and have diversified into 11 gene classes and over 100 gene families in animal evolution, and 10 to 14 gene classes in plants.
openaire   +2 more sources

HOX gene dysregulation in head and neck squamous cell carcinoma: mechanisms, clinical relevance, and future perspectives

Frontiers in Oncology
Accumulated genomic and transcriptomic evidence in head and neck squamous cell carcinoma (HNSCC) has revealed widespread molecular alterations associated with tumor initiation, progression, and therapeutic resistance.
Norma Carolina Hernandez-Bautista, Claudia Altamirano-Torres, Jose Manuel Vazquez-Guillen, Reyes S. Tamez-Guerra, Cristina Rodríguez-Padilla, Diana Resendez-Perez   +5 more
doaj   +1 more source

Fusion Gene KMT2A::SEPTIN6 in Acute Myeloid Leukemia Cell Line KOPM-88

Cells
(1) Background: KMT2A (alias MLL) is located at chromosome 11q23 and encodes histone methyltransferase 2A which activates target genes via chromatin methylation of histone H3 lysine K4.
Stefan Nagel, Corinna Meyer, Maren Kaufmann, Silke Fähnrich, Ulfert Rand, Claudia Pommerenke, Roderick A. F. MacLeod, Sonja Eberth   +7 more
doaj   +1 more source