Results 41 to 50 of about 159,528 (240)

A novel molecular link between HOXA9 and WNT6 in glioblastoma identifies a subgroup of patients with particular poor prognosis

Molecular Oncology, 2020
Despite much effort to improve treatments, patients with malignant glioma still present a very poor prognosis that has not changed significantly in the last decades.
Céline S. Gonçalves, Ana Xavier‐Magalhães, Eduarda P. Martins, Afonso A. Pinto, Manuel Melo Pires, Célia Pinheiro, Rui M. Reis, Nuno Sousa, Bruno M. Costa   +8 more
doaj   +1 more source

Hyperconserved Elements in Human 5′UTRs Shape Essential Post-transcriptional Regulatory Networks

Frontiers in Molecular Biosciences, 2020
Post-transcriptional regulation (PTR) of gene expression is a powerful determinant of cellular phenotypes. The 5′ and 3′ untranslated regions of the mRNA (UTRs) mediate this role through sequence and secondary structure elements bound by RNA-binding ...
Paola Zuccotti, Daniele Peroni, Valentina Potrich, Alessandro Quattrone, Erik Dassi   +4 more
doaj   +1 more source

HLXB9 gene expression, and nuclear location during in vitro neuronal differentiation in the SK-N-BE neuroblastoma cell line [PDF]

, 2014
Copyright @ 2014 Leotta et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source ...
Brundo, MV, Federico, C, Leotta, CG, Saccone, S, Tosi, S   +4 more
core   +1 more source

NKL homeobox gene activities in hematopoietic stem cells, T-cell development and T-cell leukemia

PLoS ONE, 2017
T-cell acute lymphoblastic leukemia (T-ALL) cells represent developmentally arrested T-cell progenitors, subsets of which aberrantly express homeobox genes of the NKL subclass, including TLX1, TLX3, NKX2-1, NKX2-5, NKX3-1 and MSX1.
S. Nagel, C. Pommerenke, M. Scherr, C. Meyer, M. Kaufmann, K. Battmer, R. MacLeod, H. Drexler   +7 more
semanticscholar   +1 more source

Lhx6 regulates the migration of cortical interneurons from the ventral telencephalon but does not specify their GABA phenotype [PDF]

, 2004
The LIM homeodomain family of transcription factors is involved in many processes in the developing CNS, ranging from cell fate specification to connectivity.
Alifragis, P, Liapi, A, Parnavelas, JG
core   +1 more source

Expression of HOXB7 in the Lung of Patients with Idiopathic Pulmonary Fibrosis: A Proof-of-Concept Study

Biomedicines
Background: The molecular pathways involved in the onset and progression of idiopathic pulmonary fibrosis (IPF) still need to be fully clarified as some are shared with lung cancer development.
Anna Valeria Samarelli, Roberto Tonelli, Giulia Raineri, Ilenia Mastrolia, Matteo Costantini, Luca Fabbiani, Virginia Catani, Tiziana Petrachi, Giulia Bruzzi, Dario Andrisani, Filippo Gozzi, Alessandro Marchioni, Valentina Masciale, Beatrice Aramini, Valentina Ruggieri, Giulia Grisendi, Massimo Dominici, Stefania Cerri, Enrico Clini   +18 more
doaj   +1 more source

Characterization of Rice Homeobox Genes, OsHOX22 and OsHOX24, and Over-expression of OsHOX24 in Transgenic Arabidopsis Suggest Their Role in Abiotic Stress Response

Frontiers in Plant Science, 2016
Homeobox transcription factors are well known regulators of plant growth and development. In this study, we carried out functional analysis of two candidate stress-responsive HD-ZIP I class homeobox genes from rice, OsHOX22, and OsHOX24. These genes were
Annapurna Bhattacharjee, J. Khurana, Mukesh Jain   +2 more
semanticscholar   +1 more source

CUT homeobox genes: transcriptional regulation of neuronal specification and beyond

Frontiers in Cellular Neuroscience, 2023
CUT homeobox genes represent a captivating gene class fulfilling critical functions in the development and maintenance of multiple cell types across a wide range of organisms.
Eduardo Leyva-Díaz
doaj   +1 more source

Coupled enhancer and coding sequence evolution of a homeobox gene shaped leaf diversity

Genes & Development, 2016
In this study, Vuolo et al. investigate the mechanisms underlying the genetic basis for morphological diversity in leaf shape. They show that evolution of an enhancer element in the homeobox gene REDUCED COMPLEXITY (RCO) altered leaf shape by changing ...
F. Vuolo, R. Mentink, Mohsen Hajheidari, C. Bailey, Dmitry A. Filatov, M. Tsiantis   +5 more
semanticscholar   +1 more source

Molecular Characterization and Subtyping of Breast Cancer Cell Lines Provide Novel Insights into Cancer Relevant Genes

Cells
Continuous cell lines are important and commonly used in vitro models in breast cancer (BC) research. Selection of the appropriate model cell line is crucial and requires consideration of their molecular characteristics.
Claudia Pommerenke, Stefan Nagel, Josephine Haake, Anne Leena Koelz, Matthias Christgen, Laura Steenpass, Sonja Eberth   +6 more
doaj   +1 more source