Results 1 to 10 of about 45,307 (198)

Evaluating the role of a novel homeodomain protein in periodontal regenerative therapy: An in-vitro study [PDF]

Journal of Oral Biology and Craniofacial Research
Introduction: The goal of periodontal treatment is to halt disease progression and restore the structure and function of damaged periodontal tissues.
Bhavya Shetty, Rohit Prasad, Amrutha Rao, Tanya Singh, Akshatha Raj, Safiya Fatima Khan   +5 more
doaj   +2 more sources

Global Analysis of Intercellular Homeodomain Protein Transfer

Cell Reports, 2019
Summary: The homeodomain is found in hundreds of transcription factors that play roles in fate determination via cell-autonomous regulation of gene expression.
Namsuk Kim, Seth Blackshaw, Jeong Ho Lee   +2 more
exaly   +3 more sources

Missense mutations in CRX homeodomain cause dominant retinopathies through two distinct mechanisms

eLife, 2023
Homeodomain transcription factors (HD TFs) are instrumental to vertebrate development. Mutations in HD TFs have been linked to human diseases, but their pathogenic mechanisms remain elusive. Here, we use Cone-Rod Homeobox (CRX) as a model to decipher the
Yiqiao Zheng, Chi Sun, Xiaodong Zhang, Philip A Ruzycki, Shiming Chen   +4 more
doaj   +1 more source

Transcriptional control of embryonic and adult neural progenitor activity

Frontiers in Neuroscience, 2023
Neural precursors generate neurons in the embryonic brain and in restricted niches of the adult brain in a process called neurogenesis. The precise control of cell proliferation and differentiation in time and space required for neurogenesis depends on ...
Niharika Singh, Niharika Singh, Florian A. Siebzehnrubl, Isabel Martinez-Garay   +3 more
doaj   +1 more source

Determination and Analysis of Hyper-Variable A Mating Types in Wild Strains of Lentinula edodes in Korea

Mycobiology, 2023
The diversity of A mating type in wild strains of Lentinula edodes was extensively analyzed to characterize and utilize them for developing new cultivars.
Mi-Jeong Park, Eunjin Kim, Yeun Sug Jeong, Mi-Young Son, Yeongseon Jang, Kang-Hyeon Ka   +5 more
doaj   +1 more source

The Role of NKL Homeobox Genes in T-Cell Malignancies

Biomedicines, 2021
Homeobox genes encode transcription factors controlling basic developmental processes. The homeodomain is encoded by the homeobox and mediates sequence-specific DNA binding and interaction with cofactors, thus operating as a basic regulatory platform ...
Stefan Nagel
doaj   +1 more source

Chromosomal Aberration t(14;17)(q32;q21) Simultaneously Activates HOXB5 and miR10a in Triple-Hit B-Cell Lymphoma

Biomedicines, 2023
BCL2, BCL6 and MYC are major oncogenes in B-cell lymphoma. Their aberrant activation frequently occurs via chromosomal translocations which juxtapose light or heavy chain immunoglobulin (IG) genes to BCL2 and MYC or fuse diverse partner genes with BCL6 ...
Stefan Nagel, Claudia Pommerenke, Corinna Meyer, Maren Kaufmann, Roderick A. F. MacLeod   +4 more
doaj   +1 more source

Loss of the transcription factor Meis1 prevents sympathetic neurons target-field innervation and increases susceptibility to sudden cardiac death

eLife, 2016
Although cardio-vascular incidents and sudden cardiac death (SCD) are among the leading causes of premature death in the general population, the origins remain unidentified in many cases.
Fabrice Bouilloux, Jérôme Thireau, Stéphanie Ventéo, Charlotte Farah, Sarah Karam, Yves Dauvilliers, Jean Valmier, Neal G Copeland, Nancy A Jenkins, Sylvain Richard, Frédéric Marmigère   +10 more
doaj   +1 more source

Development of a Molecular Marker Linked to the A4 Locus and the Structure of HD Genes in Pleurotus eryngii

Mycobiology, 2019
Allelic differences in A and B mating-type loci are a prerequisite for the progression of mating in the genus Pleurotus eryngii; thus, the crossing is hampered by this biological barrier in inbreeding.
Song Hee Lee, Asjad Ali, Byeongsuk Ha, Min-Keun Kim, Won-Sik Kong, Jae-San Ryu   +5 more
doaj   +1 more source

Posttranslational Modifications in Conserved Transcription Factors: A Survey of the TALE-Homeodomain Superclass in Human and Mouse

Frontiers in Cell and Developmental Biology, 2021
Transcription factors (TFs) guide effector proteins like chromatin-modifying or -remodeling enzymes to distinct sites in the genome and thereby fulfill important early steps in translating the genome’s sequence information into the production of proteins
Marina Reichlmeir, Lena Elias, Dorothea Schulte   +2 more
doaj   +1 more source