Results 31 to 40 of about 45,307 (198)
Ceramide synthases in mammalians, worms, and insects: emerging schemes
Biomolecular Concepts, 2010 The ceramide synthase (CerS) gene family comprises a group of highly conserved transmembrane proteins, which are found in all studied eukaryotes. The key feature of the CerS proteins is their role in ceramide synthase activity.
Voelzmann André, Bauer Reinhard
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Cell Reports, 2018 Maintenance of metabolic homeostasis requires adaption of gene regulation to the cellular energy state via transcriptional regulators. Here, we identify a role of ceramide synthase (CerS) Schlank, a multiple transmembrane protein containing a catalytic ...
Mariangela Sociale +13 more
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Cell Reports, 2017 Motor neuron axon targeting in the periphery is correlated with the positions of motor neuron inputs in the CNS, but how these processes are coordinated to form a myotopic map remains poorly understood. We show that the LIM homeodomain factor Islet (Isl)
Celine Santiago, Greg J. Bashaw
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The mating type locus (MAT) and sexual reproduction of Cryptococcus heveanensis: insights into the evolution of sex and sex-determining chromosomal regions in fungi. [PDF]
PLoS Genetics, 2010 Mating in basidiomycetous fungi is often controlled by two unlinked, multiallelic loci encoding homeodomain transcription factors or pheromones/pheromone receptors.
Banu Metin +2 more
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A look at life from the homeodomain [PDF]
The EMBO Reports, 2006 ThisThis workshop brought together developmental biologists and oncologists for three intense days of discussions about the recent progress that has been made on the roles of homeodomain proteins in development, haematopoiesis and leukaemogenesis.
Moisés, Mallo, Maria Cristina, Magli
openaire +2 more sources
eLifeNotch signaling is an evolutionarily conserved pathway for specifying binary neuronal fates, yet how it specifies different fates in different contexts remains elusive.
Chundi Xu +3 more
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A functional screen for regulators of CKDN2A reveals MEOX2 as a transcriptional activator of INK4a. [PDF]
PLoS ONE, 2009 The CDKN2A locus encodes two important tumor suppressors, INK4a and ARF, which respond to oncogenic stresses by inducing cellular senescence. We conducted a genome-scale cDNA overexpression screen using a reporter containing INK4a regulatory sequences to
Jeffrey T Irelan +6 more
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Distinct functions of homeodomain-containing and homeodomain-less isoforms encoded by homothorax [PDF]
Genes & Development, 2006 The homothorax ( hth ) gene of Drosophila melanogaster is required for executing Hox functions, for head development, and for forming the proximodistal (PD) axis of the appendages.
Barbara, Noro +4 more
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Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Tlx3 promotes glutamatergic neuronal subtype specification through direct interactions with the chromatin modifier CBP. [PDF]
PLoS ONE, 2015 Nervous system development relies on the generation of precise numbers of excitatory and inhibitory neurons. The homeodomain transcription factor, T-cell leukemia 3 (Tlx3), functions as the master neuronal fate regulator by instructively promoting the ...
Atsushi Shimomura +5 more
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