Results 31 to 40 of about 55,050 (178)
A class I odorant receptor enhancer shares a functional motif with class II enhancers
Scientific Reports, 2021 In the mouse, 129 functional class I odorant receptor (OR) genes reside in a ~ 3 megabase huge gene cluster on chromosome 7. The J element, a long-range cis-regulatory element governs the singular expression of class I OR genes by exerting its effect ...
Tetsuo Iwata +2 more
doaj +1 more source
Effect of a Mating Type Gene Editing in Lentinula edodes Using RNP/Nanoparticle Complex
Journal of FungiGene editing using CRISPR/Cas9 is an innovative tool for developing new mushroom strains, offering a promising alternative to traditional breeding methods that are time-consuming and labor-intensive.
Minseek Kim +6 more
doaj +1 more source
Ceramide synthases in mammalians, worms, and insects: emerging schemes
Biomolecular Concepts, 2010 The ceramide synthase (CerS) gene family comprises a group of highly conserved transmembrane proteins, which are found in all studied eukaryotes. The key feature of the CerS proteins is their role in ceramide synthase activity.
Voelzmann André, Bauer Reinhard
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Cell Reports, 2018 Maintenance of metabolic homeostasis requires adaption of gene regulation to the cellular energy state via transcriptional regulators. Here, we identify a role of ceramide synthase (CerS) Schlank, a multiple transmembrane protein containing a catalytic ...
Mariangela Sociale +13 more
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Investigation of homeodomain interacting protein kinase hipk2 in mouse lens development
, 2020 Lachke, Salil A.While several key transcription regulators are known to function in lens development and their mutations are linked to cataract and other ocular defects, the present knowledge on their post-translational control is limited.
Ghorpade, Priyanka
core +1 more source
Cell Reports, 2017 Motor neuron axon targeting in the periphery is correlated with the positions of motor neuron inputs in the CNS, but how these processes are coordinated to form a myotopic map remains poorly understood. We show that the LIM homeodomain factor Islet (Isl)
Celine Santiago, Greg J. Bashaw
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The mating type locus (MAT) and sexual reproduction of Cryptococcus heveanensis: insights into the evolution of sex and sex-determining chromosomal regions in fungi. [PDF]
PLoS Genetics, 2010 Mating in basidiomycetous fungi is often controlled by two unlinked, multiallelic loci encoding homeodomain transcription factors or pheromones/pheromone receptors.
Banu Metin +2 more
doaj +1 more source
eLifeNotch signaling is an evolutionarily conserved pathway for specifying binary neuronal fates, yet how it specifies different fates in different contexts remains elusive.
Chundi Xu +3 more
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A functional screen for regulators of CKDN2A reveals MEOX2 as a transcriptional activator of INK4a. [PDF]
PLoS ONE, 2009 The CDKN2A locus encodes two important tumor suppressors, INK4a and ARF, which respond to oncogenic stresses by inducing cellular senescence. We conducted a genome-scale cDNA overexpression screen using a reporter containing INK4a regulatory sequences to
Jeffrey T Irelan +6 more
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Advanced Science, EarlyView.FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni +17 more
wiley +1 more source