Results 41 to 50 of about 55,050 (178)

Tlx3 promotes glutamatergic neuronal subtype specification through direct interactions with the chromatin modifier CBP. [PDF]

PLoS ONE, 2015
Nervous system development relies on the generation of precise numbers of excitatory and inhibitory neurons. The homeodomain transcription factor, T-cell leukemia 3 (Tlx3), functions as the master neuronal fate regulator by instructively promoting the ...
Atsushi Shimomura, Dharmeshkumar Patel, Sarah M Wilson, Karl R Koehler, Rajesh Khanna, Eri Hashino   +5 more
doaj   +1 more source

Transcription Factor HOXC11 Drives Colorectal Cancer Progression and Metastasis via CAMK2A‐Dependent CXCL5 Upregulation

Advanced Science, EarlyView.
HOXC11 drives colorectal cancer progression by transcriptionally activating CAMK2A, which triggers NF‐κB–dependent CXCL5 upregulation. CXCL5–CXCR2 signaling further reinforces HOXC11 expression through the ERK1/2–SP1 axis, forming a prometastatic positive feedback loop that is effectively disrupted by combined CAMK2A and CXCR2 inhibition.
Qingyang Sun, Hengjie Xu, Sheng Yang, Jiahui Zhou, Chuanxin Tian, Hongxu Nie, Chi Jin, Tuo Wang, Zhihao Chen, Junwei Tang, Yifei Feng, Xiaowei Wang, Yueming Sun   +12 more
wiley   +1 more source

Identification of Homeobox Transcription Factors in a Dimorphic Fungus Talaromyces marneffei and Protein-Protein Interaction Prediction of RfeB

Journal of Fungi
Talaromyces marneffei is a thermally dimorphic fungus that can cause life-threatening systemic mycoses, particularly in immunocompromised individuals. Fungal homeobox transcription factors control various developmental processes, including the regulation
Monsicha Pongpom, Nopawit Khamto, Panwarit Sukantamala, Thitisuda Kalawil, Tanaporn Wangsanut   +4 more
doaj   +1 more source

Dissection of the transformation of primary human hematopoietic cells by the oncogene NUP98-HOXA9. [PDF]

PLoS ONE, 2009
NUP98-HOXA9 is the prototype of a group of oncoproteins associated with acute myeloid leukemia. It consists of an N-terminal portion of NUP98 fused to the homeodomain of HOXA9 and is believed to act as an aberrant transcription factor that binds DNA ...
Enas R Yassin, Nayan J Sarma, Anmaar M Abdul-Nabi, James Dombrowski, Ye Han, Akiko Takeda, Nabeel R Yaseen   +6 more
doaj   +1 more source

RSF1‐Dependent PAR Turnover Promotes 53BP1 Liquid Condensate Formation at DNA Damage Sites

Advanced Science, EarlyView.
At sites of DNA damage, RSF1 recruits PARG to accelerate PAR turnover, triggering a switch from PAR‐driven condensates to 53BP1 condensates. This condensate transition enables p53‐dependent gene transcription and coordinates the DNA damage response.
Yungyeong Heo, Yonghyeon Kim, Nangyeong Hwang, Gwanho Sung, Sujin Jo, Yeonhu Lee, Ho‐Chul Kang, Jae‐Ho Lee, Yong Won Choi, Hyeseong Cho, Sunwoo Min   +10 more
wiley   +1 more source

Molecular effects of novel mutations in Hesx1/HESX1 associated with human pituitary disorders [PDF]

, 2001
The homeobox gene Hesx1/HESX1 has been implicated in the establishment of anterior pattern in the central nervous system (CNS) in a number of vertebrate species.
Tyrell, R, Warner, J., Beddington, R.S., Stewart, A., Woods, K, McNay, D, Stewart, A, Warner, J, Beddington, RSP, Dattani, M, Brickman, J.M., Tyrell, R., Brickman, JM, Clements, M, Woods, K., Clements, M., McNay, D., Dattani, M.   +17 more
core  

SOX30 Facilitates Triple‐Negative Breast Cancer Metastasis via TNFR2–NF‐κB Signaling and Tumor Microenvironment Remodeling

Advanced Science, EarlyView.
SOX30 drives triple‐negative breast cancer (TNBC) metastasis through a dual mechanism: direct activation of the TNFR2/NF‐κB signaling cascade and subsequent CCL20‐mediated recruitment of tumor‐associated macrophages (TAMs) into the tumor microenvironment.
Pingping Gao, Na Sun, Ning Yang, Tingting Zhao, Rui Fu, Zhenyu Wu, Yuqin Zhou, Xuanni Tan, Yi Zhang, Fei Han, Xiaowei Qi   +10 more
wiley   +1 more source

Androgen-induced rhox homeobox genes modulate the expression of AR-regulated genes [PDF]

, 2010
Rhox5, the founding member of the reproductive homeobox on the X chromosome (Rhox) gene cluster, encodes a homeodomain-containing transcription factor that is selectively expressed in Sertoli cells, where it promotes the survival of male germ cells ...
Hu, Z.Y., Hu, Z., Verhoeven, G., De Gendt, K., Dandekar, D., Wilkinson, M.F., Wilkinson, M., O'Shaughnessy, P.J.   +7 more
core   +1 more source

Aberrant Expression and Oncogenic Activity of SPP1 in Hodgkin Lymphoma

Biomedicines
Background: Hodgkin lymphoma (HL) is a B-cell-derived malignancy and one of the most frequent types of lymphoma. The tumour cells typically exhibit multiple genomic alterations together with aberrantly activated signalling pathways, driven by paracrine ...
Stefan Nagel, Corinna Meyer
doaj   +1 more source

Structural and Biophysical Insights into the Ligand-Free Pitx2 Homeodomain and a Ring Dermoid of the Cornea Inducing Homeodomain Mutant

, 2016
The homeodomain-containing transcription factor Pitx2 (pituitary homeobox protein 2) is present in many developing embryonic tissues, including the heart.
Thomas Doerdelmann (2123581), Douglas J. Kojetin (2123578), Mark Rance (1931449), Laura A. Solt (131141), Jamie M. Baird-Titus (2123584), Thomas P. Burris (131146)   +5 more
core   +1 more source