Results 21 to 30 of about 55,050 (178)

Homeodomain-interacting protein kinase (Hipk) plays roles in nervous system and muscle structure and function

, 2020
Homeodomain-interacting protein kinases (Hipks) have been previously associated with cell proliferation and cancer, however, their effects in the nervous system are less well understood.
Simon J. H. Wang (8595363), Donald A. R. Sinclair (8595366), Kenneth K. L. Wong (8595381), Claire R. Y. Shih (8595378), Hae-Yoon Kim, Kenneth K L Wong, Charles Krieger, Charles Krieger (400531), Donald A R Sinclair, Byoungjoo Yoo, Nicholas Harden (400587), Esther M Verheyen, Simon J H Wang, Esther M. Verheyen (8208786), Stephen D Kinsey, Claire R Y Shih, Hae-Yoon Kim (8595369), Nicholas Harden, Byoungjoo Yoo (8595375), Stephen D. Kinsey (8595372)   +19 more
core   +1 more source

Differential Water Networks Guide Selectivity Optimization of a Cell Active BPTF Inhibitor in Neuroblastoma

Angewandte Chemie, EarlyView.
BZ2 is a second‐generation Bromodomain PHD finger Transcription Factor (BPTF) inhibitor with improved selectivity over Class I and Class IV BRD off‐targets identified in our previously reported inhibitor, BZ1. Structural analyses reveal that water network engagement is key to this selectivity.
Kesavan Babu, Chun‐Ju Tsou, Sourav Das, Liying Fan, Anasuya Pal, Molly Sneddon, Timothy R. Stachowski, Priyanka Samanta, Stanley Nithianantham, Caroline Buchholz, Shi Zhang, Xiang Fu, Rahul S. Kathayat, Wenwei Lin, Yongtao Li, Lei Yang, Taosheng Chen, Marcus Fischer, Anang A. Shelat, William C. K. Pomerantz   +19 more
wiley   +2 more sources

Single‐cell RNA sequencing of motoneurons identifies regulators of synaptic wiring in Drosophila embryos

Molecular Systems Biology, 2022
The correct wiring of neuronal circuits is one of the most complex processes in development, since axons form highly specific connections out of a vast number of possibilities. Circuit structure is genetically determined in vertebrates and invertebrates,
Jessica Velten, Xuefan Gao, Patrick Van Nierop y Sanchez, Katrin Domsch, Rashi Agarwal, Lena Bognar, Malte Paulsen, Lars Velten, Ingrid Lohmann   +8 more
doaj   +1 more source

Homeodomain proteins: an update [PDF]

, 2015
Here, we provide an update of our review on homeobox genes that we wrote together with Walter Gehring in 1994. Since then, comprehensive surveys of homeobox genes have become possible due to genome sequencing projects.
Markus Affolter, Thomas R. Bürglin, Affolter, Markus, Bürglin, Thomas R.   +3 more
core   +2 more sources

Cellular and Molecular Mechanisms regulating Cell Proliferation during the Forebrain Development of the Mouse [PDF]

, 2005
The predominant precursor cell type during cortical neurogenesis are radial glia cells, which receive extrinsic and intrinsic signals that might influence cell proliferation and neurogenesis.
Haubst, Nicole
core   +1 more source

Analyses of binding partners and functional domains for the developmentally essential protein Hmx3a/HMX3

Scientific Reports, 2023
HMX3 is a homeodomain protein with essential roles in CNS and ear development. Homeodomains are DNA-binding domains and hence homeodomain-containing proteins are usually assumed to be transcription factors.
William Haws, Samantha England, Ginny Grieb, Gabriela Susana, Sophie Hernandez, Hunter Mirer, Katharine Lewis   +6 more
doaj   +1 more source

Homeodomain proteins hierarchically specify neuronal diversity and synaptic connectivity

eLife
How our brain generates diverse neuron types that assemble into precise neural circuits remains unclear. Using Drosophila lamina neuron types (L1-L5), we show that the primary homeodomain transcription factor (HDTF) brain-specific homeobox (Bsh) is ...
Chundi Xu, Tyler B Ramos, Edward M Rogers, Michael B Reiser, Chris Q Doe   +4 more
doaj   +1 more source

Regulation of Silk Genes by Hox and Homeodomain Proteins in the Terminal Differentiated Silk Gland of the Silkworm Bombyx mori

Journal of Developmental Biology, 2016
The silk gland of the silkworm Bombyx mori is a long tubular organ that is divided into several subparts along its anteroposterior (AP) axis. As a trait of terminal differentiation of the silk gland, several silk protein genes are expressed with unique ...
Shigeharu Takiya, Takuya Tsubota, Mai Kimoto   +2 more
doaj   +1 more source

Isolation and sequence-specific DNA binding of the Antennapedia homeodomain.

, 1988
The homeodomain encoded by the Antennapedia (Antp) gene of Drosophila was overproduced in a T7 expression vector in Escherichia coli. The corresponding polypeptide of 68 amino acids was purified to homogeneity.
Leupin, W., Affolter, M., Müller, M., Otting, G., Wüthrich, K., Gehring, W. J.   +5 more
core   +2 more sources

Advances in Understanding Mating Type Gene Organization in the Mushroom-Forming Fungus Flammulina velutipes

G3: Genes, Genomes, Genetics, 2016
The initiation of sexual development in the important edible and medicinal mushroom Flammulina velutipes is controlled by special genes at two different, independent, mating type (MAT) loci: HD and PR. We expanded our understanding of the F.
Wei Wang, Lingdan Lian, Ping Xu, Tiansheng Chou, Irum Mukhtar, Aron Osakina, Muhammad Waqas, Bingzhi Chen, Xinrui Liu, Fang Liu, Baogui Xie, Arend F. van Peer   +11 more
doaj   +1 more source