Homeodomain Proteins Directly Regulate ATM Kinase Activity
Cell Reports, 2018 Summary: Ataxia-telangiectasia mutated (ATM) is a serine/threonine kinase that coordinates the response to DNA double-strand breaks and oxidative stress.
Tanya E. Johnson +8 more
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Transcriptional regulation of the human ALDH1A1 promoter by the oncogenic homeoprotein TLX1/HOX11 [PDF]
Hematology Reports, 2009 The homeoprotein TLX1, which is essential to spleen organogenesis and oncogenic when aberrantly expressed in immature T cells, functions as a bifunctional transcriptional regulator, being capable of activation or repression depending on cell type and/or ...
Kim Rice +4 more
doaj +2 more sources
Evaluating the role of a novel homeodomain protein in periodontal regenerative therapy: An in-vitro study [PDF]
Journal of Oral Biology and Craniofacial ResearchIntroduction: The goal of periodontal treatment is to halt disease progression and restore the structure and function of damaged periodontal tissues.
Bhavya Shetty +5 more
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Sequence-specific targeting of nuclear signal transduction pathways by homeodomain proteins [PDF]
, 1995 Cells translate extracellular signals into specific programs of gene expression that reflect their developmental history or identity. We present evidence that one way this interpretation may be performed is by cooperative interactions between serum ...
Grueneberg, D. A. +3 more
core +11 more sources
Decoding the mechanisms of cooperative DNA binding by the Paired-like homeodomain family [PDF]
Nature CommunicationsThe 36 Paired-like homeodomain transcription factors in humans are required for the development of many cell types, tissues, and organs as missense variants in 24 Paired-like genes have been associated with numerous diseases and developmental disorders ...
Brittany Cain +3 more
doaj +2 more sources
A Recessive Mutation Resulting in a Disabling Amino Acid Substitution (T194R) in the LHX3 Homeodomain Causes Combined Pituitary Hormone Deficiency [PDF]
, 2012 Background/Aims: Recessive mutations in the LHX3 homeodomain transcription factor gene are associated with developmental disorders affecting the pituitary and nervous system. We describe pediatric patients with combined pituitary hormone deficiency (CPHD)
Hiedl, Stefan +7 more
core +1 more source
Multiple functions of LIM domain-binding CLIM/NLI/Ldb cofactors during zebrafish development [PDF]
, 2002 The crucial involvement of CLIM/NLI/Ldb cofactors for the exertion of the biological activity of LIM homeodomain transcription factors (LIM-HD) has been demonstrated.
Bossenz, Michael +6 more
core +1 more source
Drosophila Homeodomain-Interacting Protein Kinase (Hipk) Phosphorylates the Homeodomain Proteins Homeobrain, Empty Spiracles, and Muscle Segment Homeobox [PDF]
, 2019 The Drosophila homeodomain-interacting protein kinase (Hipk) is the fly representative of the well-conserved group of HIPKs in vertebrates. It was initially found through its characteristic interactions with homeodomain proteins.
Steinmetz, Eva Louise +3 more
core +2 more sources
Homeodomain proteins directly regulate ATM kinase activity [PDF]
, 2020 The ataxia-telangiectasia mutated (ATM) kinase is a master regulator involved in the detection and repair of DNA double-strand breaks (DSBs). The Mre11/Rad50/Nbs1 (MRN) complex recruits and activates ATM at DSBs, causing a signaling cascade to initiate ...
Johnson, Tanya Ellen
core +1 more source
The Colletotrichum lagenarium Ste12-Like Gene CST1 Is Essential for Appressorium Penetration
Molecular Plant-Microbe Interactions, 2003 Colletotrichum lagenarium is the causal agent of anthracnose of cucumber. This fungus produces a darkly melanized infection structure, appressoria, to penetrate the host leaves. The C.
Gento Tsuji +4 more
doaj +1 more source