Results 21 to 30 of about 82,771 (160)

Hyperconserved Elements in Human 5′UTRs Shape Essential Post-transcriptional Regulatory Networks

Frontiers in Molecular Biosciences, 2020
Post-transcriptional regulation (PTR) of gene expression is a powerful determinant of cellular phenotypes. The 5′ and 3′ untranslated regions of the mRNA (UTRs) mediate this role through sequence and secondary structure elements bound by RNA-binding ...
Paola Zuccotti, Daniele Peroni, Valentina Potrich, Alessandro Quattrone, Erik Dassi   +4 more
doaj   +1 more source

ERN1 dependent impact of glucose and glutamine deprivations on PBX3, PBXIP1, PAX6, MEIS1, and MEIS2 genes expression in U87 glioma cells

Endocrine Regulations, 2023
Objective. Homeobox genes play a fundamental role in the embryogenesis, but some of them have been linked to oncogenesis. The present study is aimed to investigate the impact of glucose and glutamine deprivations on the expression of homeobox genes such ...
Krasnytska Dariia O., Viletska Yuliia M., Minchenko Dmytro O., Khita Olena O., Tsymbal Dariia O., Cherednychenko Anastasiia A., Kozynkevych Halyna E., Oksiom Nataliia S., Minchenko Oleksandr H.   +8 more
doaj   +1 more source

Evolution of the Homeobox Complex in the Diptera [PDF]

Current Biology, 2003
The homeobox-complex (HOX-C) programs much of the basic body plan and forms, in most metazoans, one continuous cluster with the order of genes paralleling their order of expression along the body axis [1–5]. Here we compare the HOX-C organization of several Drosophila species and of Anopheles gambiae, a representative of lower Dipterans.
Lewis, Edward B., Pfeiffer, Barret D., Mathog, David R., Celniker, Susan E.   +3 more
openaire   +2 more sources

Expression of HOXB7 in the Lung of Patients with Idiopathic Pulmonary Fibrosis: A Proof-of-Concept Study

Biomedicines
Background: The molecular pathways involved in the onset and progression of idiopathic pulmonary fibrosis (IPF) still need to be fully clarified as some are shared with lung cancer development.
Anna Valeria Samarelli, Roberto Tonelli, Giulia Raineri, Ilenia Mastrolia, Matteo Costantini, Luca Fabbiani, Virginia Catani, Tiziana Petrachi, Giulia Bruzzi, Dario Andrisani, Filippo Gozzi, Alessandro Marchioni, Valentina Masciale, Beatrice Aramini, Valentina Ruggieri, Giulia Grisendi, Massimo Dominici, Stefania Cerri, Enrico Clini   +18 more
doaj   +1 more source

Molecular Characterization and Subtyping of Breast Cancer Cell Lines Provide Novel Insights into Cancer Relevant Genes

Cells
Continuous cell lines are important and commonly used in vitro models in breast cancer (BC) research. Selection of the appropriate model cell line is crucial and requires consideration of their molecular characteristics.
Claudia Pommerenke, Stefan Nagel, Josephine Haake, Anne Leena Koelz, Matthias Christgen, Laura Steenpass, Sonja Eberth   +6 more
doaj   +1 more source

An update on the vertebrate homeobox [PDF]

Trends in Genetics, 1989
Given the complexity of development and the multitude of differentiated cell types in higher eukaryotic organisms, one might expect that a large variety of proteins would be required to regulate specific developmental processes. However, if the differentiated state of a particular cell is specified not by a single protein but by a combination of ...
openaire   +3 more sources

CUT homeobox genes: transcriptional regulation of neuronal specification and beyond

Frontiers in Cellular Neuroscience, 2023
CUT homeobox genes represent a captivating gene class fulfilling critical functions in the development and maintenance of multiple cell types across a wide range of organisms.
Eduardo Leyva-Díaz
doaj   +1 more source

Evaluating the Level of Homeobox B8 and its Association with Cell Lung Cancer Proliferation Downregulation: A Systematic Review and Meta-analysis [PDF]

International Journal of Scientific Research in Dental and Medical Sciences
Background and aim: Homeobox family genes have been identified as cancer growth regulators. There is no meta-analysis or comprehensive study on the activity of Homeobox B8 (HOXB8) in lung cancer.
Maryam Hassanpour Amnieh, Samira Jalalinezhad, Mahsa Hajizadeh, Majid Hajizadeh   +3 more
doaj   +1 more source

The NKL- and TALE-Codes Represent Hematopoietic Gene Signatures to Evaluate Deregulated Homeobox Genes in Hodgkin Lymphoma

Hemato, 2022
Homeobox genes encode transcription factors which control basic processes in development and differentiation. Concerning the sequence conservation in their homeobox, these genes are arranged into particular groups sharing evolutionary ancestry and ...
Stefan Nagel
doaj   +1 more source

‘Organ’ising Floral Organ Development

Plants
Flowers are plant structures characteristic of the phylum Angiosperms composed of organs thought to have emerged from homologous structures to leaves in order to specialize in a distinctive function: reproduction.
Kestrel A. Maio, Laila Moubayidin
doaj   +1 more source