Results 31 to 40 of about 99,018 (274)
Endocrine Regulations, 2023 Objective. Homeobox genes play a fundamental role in the embryogenesis, but some of them have been linked to oncogenesis. The present study is aimed to investigate the impact of glucose and glutamine deprivations on the expression of homeobox genes such ...
Krasnytska Dariia O. +8 more
doaj +1 more source
Evolution of the Homeobox Complex in the Diptera [PDF]
Current Biology, 2003 The homeobox-complex (HOX-C) programs much of the basic body plan and forms, in most metazoans, one continuous cluster with the order of genes paralleling their order of expression along the body axis [1–5]. Here we compare the HOX-C organization of several Drosophila species and of Anopheles gambiae, a representative of lower Dipterans.
Lewis, Edward B. +3 more
openaire +2 more sources
Hepatology, EarlyView., 2022 Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong +9 more
wiley +1 more source
BiomedicinesBackground: The molecular pathways involved in the onset and progression of idiopathic pulmonary fibrosis (IPF) still need to be fully clarified as some are shared with lung cancer development.
Anna Valeria Samarelli +18 more
doaj +1 more source
CellsContinuous cell lines are important and commonly used in vitro models in breast cancer (BC) research. Selection of the appropriate model cell line is crucial and requires consideration of their molecular characteristics.
Claudia Pommerenke +6 more
doaj +1 more source
CUT homeobox genes: transcriptional regulation of neuronal specification and beyond
Frontiers in Cellular Neuroscience, 2023 CUT homeobox genes represent a captivating gene class fulfilling critical functions in the development and maintenance of multiple cell types across a wide range of organisms.
Eduardo Leyva-Díaz
doaj +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Evaluating the Level of Homeobox B8 and its Association with Cell Lung Cancer Proliferation Downregulation: A Systematic Review and Meta-analysis [PDF]
International Journal of Scientific Research in Dental and Medical SciencesBackground and aim: Homeobox family genes have been identified as cancer growth regulators. There is no meta-analysis or comprehensive study on the activity of Homeobox B8 (HOXB8) in lung cancer.
Maryam Hassanpour Amnieh +3 more
doaj +1 more source
Hemato, 2022 Homeobox genes encode transcription factors which control basic processes in development and differentiation. Concerning the sequence conservation in their homeobox, these genes are arranged into particular groups sharing evolutionary ancestry and ...
Stefan Nagel
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source