Results 191 to 200 of about 2,139,288 (317)

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang, Dongxu Zhang, Dongyuan Liu, Da Lin, Hao Wang   +4 more
wiley   +1 more source

Associations of Sleep and Shift Work With Osteoarthritis Risk

Arthritis Care &Research, EarlyView.
Objective Daily rhythms may be critical for maintaining homeostasis of joint tissues. We aimed to investigate the relationships among circadian clock disruption, sleep, and osteoarthritis (OA) risk in humans. Methods In the UK Biobank, a prospective 500,000–person cohort, we evaluated associations among sleep duration, sleeplessness/insomnia, and shift
Elizabeth L. Yanik, Abigail Bridgeman, Erik D. Herzog, Vy Pham, Bradley A. Evanoff, Farshid Guilak   +5 more
wiley   +1 more source

Exercise Exerts Antidepressant Effects via Endoplasmic Reticulum Stress Modulation: Molecular Mechanisms and Research Progress. [PDF]

Biology (Basel)
Zhou XY, Liu YW, Zhong CH, Xu R, Guan K, Li HN, Huang JT, Xue K, Wang Y, Chen XH.   +9 more
europepmc   +1 more source

Does Long‐Term Lower Extremity Strength Training in Adults With Knee Osteoarthritis and Varus Alignment Reduce Knee Joint Loading During Gait?

Arthritis Care &Research, EarlyView.
Objective We examined whether 18 months of strength training in individuals with knee varus alignment and medial tibiofemoral osteoarthritis (OA) reduced knee joint loads during walking compared to an attention control group. Methods This study was a secondary analysis of a randomized clinical trial that compared the effects of strength training to a ...
Stephen P. Messier, Matthew N. Vigliotti, Paige E. Rice, Brian Pietrosimone, Shannon L. Mihalko, Edward H. Ip, Richard F. Loeser, David J. Hunter, Ali Guermazi, Ryan Hill, Santiago Saldana, Kim L. Bennell, Paul DeVita   +12 more
wiley   +1 more source

Glutamine-Linked Cellular Stress Responses in Viral Infection: Mechanisms, Crosstalk, and Future Perspectives. [PDF]

Int J Mol Sci
Pham NTK, Trinh QD, Ushijima H, Komine-Aizawa S, Yoshimune K.   +4 more
europepmc   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

KDM6B safeguards mineralized tissue homeostasis from mechanical stress through epigenetic control of PIEZO1-mediated mechanotransduction in the mouse incisor. [PDF]

Bone Res
Meng L, Zhang M, Feng J, Guo T, Hekmat H, Ziaei H, Chen P, Harouni A, Ho TV, Chai Y.   +9 more
europepmc   +1 more source

Incorporation of Selenium into Sol–Gel‐Derived Bioactive Glass: Influence on Glass Structure, Bioactivity, and its Selective Cytotoxicity

Advanced Engineering Materials, EarlyView.
Selenium was incorporated into a sol–gel‐derived bioactive glass to enable sustained therapeutic ion release. The selenium‐containing glass preserved bioactivity while selectively inducing cytotoxicity in osteosarcoma cells and maintaining osteoblastic viability.
Breno Rocha Barrioni, Thalita Marcolan Valverde, Talita Martins, Guilherme Mattos Jardim Costa, Alfredo Miranda de Goes, Marcello Rosa Dumont, Eduardo Henrique Martins Nunes, Marivalda de Magalhães Pereira   +7 more
wiley   +1 more source

Breast cancer-related endocrine therapy on ocular surface microbiota: mechanism and clinical significance. [PDF]

Int J Ophthalmol
Yuan C, Hu XC, Tan RX, Liu C.
europepmc   +1 more source

Neuraxial Homeostasis – Optimizing Neuraxial Labor Analgesia

Jianwei Guo, Yan Cheng, Minmin Yi Department of Anesthesiology, Shaanxi Provincial People’s Hospital, Xi’an, Shaanxi, 710068, People’s Republic of ChinaCorrespondence: Yan Cheng, Department of Anesthesiology, Shaanxi Provincial People’s Hospital, Xi’an ...
Guo J, Yi M, Cheng Y
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