Results 31 to 40 of about 392,877 (295)

Homer signaling pathways as effective therapeutic targets for ischemic and traumatic brain injuries and retinal lesions

open access: yesNeural Regeneration Research, 2022
Ischemic and traumatic insults to the central nervous system account for most serious acute and fatal brain injuries and are usually characterized by primary and secondary damage.
Xiu-Quan Wu, Ning Su, Zhou Fei, Fei Fei
doaj   +1 more source

All Shall Fade: Homer\u27s Foreshadowing of the End of the Heroic Age in The Iliad [PDF]

open access: yes, 2015
Homer\u27s epic poems are filled with demi-gods and great heroes. However, in The Iliad, Homer undermines the triumph of these heroes by foreshadowing the end of their age and the forthcoming time of mortals. This essay examines how Achilleus\u27 shield,
Hardy, Sabrina
core   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

open access: yesMolecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal   +4 more
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Crossing Dreams: the Neglected Dreams of the Homeric Poems and the Poetics of Epic [PDF]

open access: yesRevista de Istorie și Teorie Literară
This article explores the status of dreams in Homer’s Iliad and Odyssey.Dreams serve many different purposes in the epic; they also continuously elude all attempts to define or categorize them in a single, conclusive way.
Dorin Garofeanu
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Studi Kelayakan Pembangkit Listrik Tenaga Hybrid Surya Bayu di Kota Bandung

open access: yesJurnal Elkomika, 2023
ABSTRAK Pada penelitian ini dilakukan analisis studi kelayakan potensi pembangkit listrik tenaga hybrid dengan sumber energi terbarukan surya dan bayu untuk skala rumah tangga di daerah kota Bandung.
FEBRIAN HADIATNA   +2 more
doaj   +1 more source

Evolutionary insights into premetazoan functions of the neuronal protein homer. [PDF]

open access: yes, 2014
Reconstructing the evolution and ancestral functions of synaptic proteins promises to shed light on how neurons first evolved. The postsynaptic density (PSD) protein Homer scaffolds membrane receptors and regulates Ca(2+) signaling in diverse metazoan ...
Burkhardt, Pawel   +5 more
core   +1 more source

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