Results 61 to 70 of about 33,434 (269)
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Homer, Troy and Architecture. On Founding and Building Perfections
Anglica. An International Journal of English StudiesThe idea of founding perfection on abstract and idealised patterns the model of which is broadly understood as geometry seems to be responsible for a certain utopianism characterising various aspects of thinking about change and improvement.
Tadeusz Rachwał
doaj +1 more source
Una imatge val per mil paraules
Digithum, 1999 Una vegada hi havia un videoclub ple de pel·lícules i a l'entrada hi havia un rètol lluminós molt bonic que deia el lema d'aquesta casa, que és una imatge val per mil paraules.
Jaume Cabré
doaj +1 more source
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
CULTURE AND HOUSING – IN THE ROMANIAN VILLAGE AND IN THE HOMERIC TRADITION
EtnosferaThe spatial dimension is not just one of the coordinates of cultural development, but rather a condition for its manifestation. This is easily seen in the analysis of family culture.
Corina Pantelimon-Bistriceanu
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Anglica. An International Journal of English Studies, 2021 Madeline Miller’s The Song of Achilles (2011) is an imaginative rewriting of Homer’s Iliad. The writer uses the strategy of transfocalization and enters the text from the point of view of Patroclus.
Maria Antonietta Struzziero
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Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Odysseus "Božské komedie" a limity lidského vědění
Filosofický časopisThe goal of this text is to examine the morally devised limits of human knowledge using examples from an exposition of Odysseus’ journey beyond the Pillars of Heracles found in Canto XXVI of Dante’s Divine Comedy.
Jiráňová, Polina
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source