Results 211 to 220 of about 9,189 (259)

AI-driven smart grid optimization for hospital energy systems integrating renewable generation, predictive maintenance, and resilient infrastructure. [PDF]

Sci Rep
Sarker MT, Ramasamy G, Al Qwaid M, Hossen MS, Sadeque MG.   +4 more
europepmc   +1 more source

Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid‐β Production and Cognitive Dysfunctions in Alzheimer's Disease

Advanced Science, EarlyView.
This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon, Mireille Elodie Tsitokana, Ugo Guy Alenda, Yen‐Ling Lian, Clémentine Eva Philibert, Mathieu Oosterlaken, Marta Cimadevila, Gaëlle Dudon, Jessica Monnic, Salomé Roux, Julie Bessié, Séverine Diem, Franck Vandermoere, Laurent Prézeau, Patrick Chames, Julie Kniazeff, Sylvie Claeysen, Anaïs Menny, Jean‐Philippe Pin, Véronique Perrier, Jianfeng Liu, Philippe Rondard   +21 more
wiley   +1 more source

Structural Modeling and Dynamics of the Full-Length Homer1 Multimer. [PDF]

Proteins
Kálmán ZE, Czajlik A, Maruzs B, Farkas F, Pap I, Homonnay C, Klumpler T, Batta G, Gáspári Z, Péterfia B.   +9 more
europepmc   +1 more source

Tumor‐Intrinsic ARHGEF3 Enhances Antitumor Immunity by Promoting T‐Cell Infiltration and Limiting Myeloid Cell‐Mediated Immunosuppression

Advanced Science, EarlyView.
ARHGEF3 is broadly downregulated across human cancers and correlates with patient prognosis. Tumor‐intrinsic ARHGEF3 activates the RHOA–ROCK–PTEN cascade to inhibit AKT signaling, thereby promoting chemokine‐driven T‐cell infiltration and relieving lipid‐mediated myeloid immunosuppression.
Yue Li, Lan Wang, Zihao Zhang, Chunmei Qian, Ning Li, Wei Huang, Qian Ba, Xiaojian Liu, Mayu Sun   +8 more
wiley   +1 more source

mTOR inhibition promotes ATRA-induced cancer cell differentiation by overcoming a metabolic hyperactive state. [PDF]

J Transl Med
Zhang L, Xiang G, Zhu P, Yu S, Jiang F, Wang S, Wang J, Dai Y, Wang S, Tan Y, Liu H, Liu F.   +11 more
europepmc   +1 more source

Energetic and cost analysis of two conversion systems connected to the Grid by using Homer pro

International Journal of Renewable Energy Research, 2015
openaire   +1 more source

Multi‐Omics Insights Into the Mechanisms of Early Muscle Fiber Difference and Transformation Between Lean‐Type and Chinese Indigenous Pigs

Advanced Science, EarlyView.
Multi‐omics analyses uncover breed‐specific cis‐regulatory landscapes and higher‐order chromatin architectural differences that underlie early postnatal muscle fiber divergence in pigs. A super‐enhancer upstream of PPP3CB recruits MEF2C to activate PPP3CB transcription, while the PPP3CB–MEF2C positive feedback loop promotes oxidative muscle fiber ...
Shuailong Zheng, Hainan Wu, Min Liu, Kunpeng Wu, Shuntao Huang, Zulfiqar Ahmed, Lenox Pius, Mengjin Zhu, Dequan Xu   +8 more
wiley   +1 more source

A novel holistic metric for sustainability assessment of photovoltaic/battery systems. [PDF]

Sci Rep
Elazab R, Daowd M.
europepmc   +1 more source

Optimization of B Cell Responses in Human Immune System Mice Through Organoid Based Screening

Advanced Science, EarlyView.
Human immune system (HIS) mice show limited B cell responses to immunization. Using HIS mouse spleen organoids, this study identifies cytokine combinations and innate immune signals that drive human B cell expansion, differentiation, and class‐switch. Applying these signals in vivo through temporal separation enables antigen‐specific IgG responses and ...
Haiqiao Sun, He Li, Xu Zhu, Zijian Zhang, Deshan Ren, Shuai Ding, Yan Li   +6 more
wiley   +1 more source

Leukemia risk factor ARID5B coordinates HDAC-mediated transcriptional repression. [PDF]

Nucleic Acids Res
Kutschat AP, Frommelt F, Santini BL, Müller S, Batty P, Awasthi A, Karbon G, Superti-Furga G, Seruggia D.   +8 more
europepmc   +1 more source