Results 231 to 240 of about 1,546,463 (301)

Bifidobacterium Pseudolongum‐Derived Inosine Mitigates Polystyrene Nanoplastics‐Induced Hepatic Injury by Inhibiting the Polarization of M1 Macrophages

Advanced Science, EarlyView.
Probiotic B.p colonization elevated gut‐derived inosine level in the liver, while elevated inosine activated A2AR and subsequently blocked NPs‐induced polarization of M1 macrophages by repressing the miR155/SOCS1/NF‐κB pathway. This reduced the release of inflammatory cytokines and thereby, mitigated NPs‐induced hepatic injury.
Kaikai Zhang, Yuchuan Chen, Jiayuan Wan, Jianzheng Yang, Lijian Chen, Qingyuan Li, Anding Zhou, Nian Zhou, Jiuyang Ding, Qi Wang, Jian Sun   +10 more
wiley   +1 more source

Decoding Synaptic Diversity: Molecular Architectures, Phase Transitions, and Shared Postsynaptic Failure in Alzheimer's and Parkinson's Disease. [PDF]

Cells
Cipriano GL, Anchesi I, Floramo A, Argento V, Spinelli S, Astorino MF, Calabrò M, Artimagnella O.   +7 more
europepmc   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

The response to kidney injury is epigenetically regulated through the activation of bivalent genes. [PDF]

Am J Physiol Renal Physiol
Tickman BI, McDonald JR, McCarthy R, Suh K, Okamura DM, Houghtaling SR, Collins SJ, Bae Y, Beier DR, Majesky MW, Nguyen ED.   +10 more
europepmc   +1 more source

The Mind From Within: Visceral Roots of Human Cognition

Advanced Science, EarlyView.
The physiological activity of visceral organs, such as the heart, the lungs, and the gut, is surprisingly linked to many sophisticated mental operations, such as remembering the past, being aware of ourselves, making choices, and forging social bonds.
Alessandro Monti, Salvatore Maria Aglioti   +1 more
wiley   +1 more source

Economic and environmental assessment of different energy storage methods for hybrid energy systems. [PDF]

Sci Rep
Liu Y, Zhang Y.
europepmc   +1 more source

Optimization of B Cell Responses in Human Immune System Mice Through Organoid Based Screening

Advanced Science, EarlyView.
Human immune system (HIS) mice show limited B cell responses to immunization. Using HIS mouse spleen organoids, this study identifies cytokine combinations and innate immune signals that drive human B cell expansion, differentiation, and class‐switch. Applying these signals in vivo through temporal separation enables antigen‐specific IgG responses and ...
Haiqiao Sun, He Li, Xu Zhu, Zijian Zhang, Deshan Ren, Shuai Ding, Yan Li   +6 more
wiley   +1 more source

Dynamics of neutrophilia at the neurovascular unit arising from repeated pulmonary inflammation. [PDF]

J Neuroinflammation
Chiang W, Li H, Le L, David-Bercholz J, Caceres AI, Ahmad D, Squire E, Stecyk KS, Marrero M, Pereira A, Squire R, Lim C, McGrath JL, Majewska AK, Terrando N, Gelbard HA.   +15 more
europepmc   +1 more source

Toward Prostate Cancer Early Warning with a Self‐Powered Wearable Biosensing Platform Integrated with Machine Learning

Advanced Science, EarlyView.
ABSTRACT Current prostate cancer detection methods remain limited in non‐invasiveness and specificity, prompting interest in urinary biomarkers such as sarcosine. Here, we report a urine‐powered wearable platform for non‐invasive sarcosine detection as a proof‐of‐concept for decentralized early warning.
Jing Xu, Hanxiao Chen, Qichen Yuan, Liucun Yin, Yifang Tao, Hong Wang, Yuquan Xue, Delai Fu, Huan Pang, Tie Chong, Li Xue   +10 more
wiley   +1 more source

Ischemic stroke triggers brain-wide synaptic remodeling within four hours. [PDF]

PLoS Biol
Chen H, Wei Y, Ruje L, Du F, Feng Z, Wan Q, Spivakov M, Glebov OO.   +7 more
europepmc   +1 more source