Results 231 to 240 of about 142,923 (315)

Regional-local urinary antibiograms for long-term care homes: a population-wide cross-sectional study. [PDF]

J Clin Microbiol
Langford BJ, Brown KA, Swayze S, Castellani L, Dalton D, Emdin F, Langleben I, Lee S, Leung V, Matukas L, Oberai A, Schwartz KL, Daneman N.   +12 more
europepmc   +1 more source

Supporting Older People in Care Homes at Night

, 2008
Kerr, Diana, Wilkinson, Heather, Cunningham, Colm   +2 more
core  

Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid‐β Production and Cognitive Dysfunctions in Alzheimer's Disease

Advanced Science, EarlyView.
This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon, Mireille Elodie Tsitokana, Ugo Guy Alenda, Yen‐Ling Lian, Clémentine Eva Philibert, Mathieu Oosterlaken, Marta Cimadevila, Gaëlle Dudon, Jessica Monnic, Salomé Roux, Julie Bessié, Séverine Diem, Franck Vandermoere, Laurent Prézeau, Patrick Chames, Julie Kniazeff, Sylvie Claeysen, Anaïs Menny, Jean‐Philippe Pin, Véronique Perrier, Jianfeng Liu, Philippe Rondard   +21 more
wiley   +1 more source

Implementing an intervention to facilitate early detection of deterioration in aged care residents: process evaluation of the EDDIE + trial. [PDF]

Implement Sci
Bracci EL, Allen MJ, Carter HE, Cyarto E, Dwyer T, Farrington A, Graves N, Lee XJ, Meyer C, Oprescu F, Rowland J, Shield C, White N, Harvey G.   +13 more
europepmc   +1 more source

Tumor‐Intrinsic ARHGEF3 Enhances Antitumor Immunity by Promoting T‐Cell Infiltration and Limiting Myeloid Cell‐Mediated Immunosuppression

Advanced Science, EarlyView.
ARHGEF3 is broadly downregulated across human cancers and correlates with patient prognosis. Tumor‐intrinsic ARHGEF3 activates the RHOA–ROCK–PTEN cascade to inhibit AKT signaling, thereby promoting chemokine‐driven T‐cell infiltration and relieving lipid‐mediated myeloid immunosuppression.
Yue Li, Lan Wang, Zihao Zhang, Chunmei Qian, Ning Li, Wei Huang, Qian Ba, Xiaojian Liu, Mayu Sun   +8 more
wiley   +1 more source

Educational Interventions on Chronic Kidney Disease for Care Home Staff: An Empty Scoping Review. [PDF]

Nurs Rep
Crolly-Burton G, Mitchell G, McKeaveney C, Craig S.   +3 more
europepmc   +1 more source

Multi‐Omics Insights Into the Mechanisms of Early Muscle Fiber Difference and Transformation Between Lean‐Type and Chinese Indigenous Pigs

Advanced Science, EarlyView.
Multi‐omics analyses uncover breed‐specific cis‐regulatory landscapes and higher‐order chromatin architectural differences that underlie early postnatal muscle fiber divergence in pigs. A super‐enhancer upstream of PPP3CB recruits MEF2C to activate PPP3CB transcription, while the PPP3CB–MEF2C positive feedback loop promotes oxidative muscle fiber ...
Shuailong Zheng, Hainan Wu, Min Liu, Kunpeng Wu, Shuntao Huang, Zulfiqar Ahmed, Lenox Pius, Mengjin Zhu, Dequan Xu   +8 more
wiley   +1 more source

The characteristics of patients' medical care, living will, and signs of death by age and the place of death: A cross-sectional study using a questionnaire survey targeting physicians with expertise in end-of-life care. [PDF]

PLoS One
Yakabe M, Hosoi T, Matsumoto S, Miura S, Hoshi K, Iwao S, Kitamura Y, Akishita M, Ogawa S.   +8 more
europepmc   +1 more source

Nanozymes for Advanced Hemoglobin‐Based Oxygen Carriers: Applications in Blood Substitution, Wound Healing, Antitumor Therapy, and Beyond

Advanced Science, EarlyView.
This review explores how hemoglobin‐based oxygen carriers (HBOCs) combined with nanozymes create multifunctional materials that deliver oxygen while maintaining redox homeostasis. Beyond artificial blood substitutes, these constructs enable wound healing with light‐triggered oxygen release, cancer therapy through enhanced oxygenation and reactive ...
Despoina Douka, Ana María Pablo‐Sainz‐Ezquerra, Eva Jakljevič, Niki Ktena, Leticia Hosta‐Rigau   +4 more
wiley   +1 more source

Academic Nurse Educators' Experiences and Perceptions of Supporting Adult Nursing Students in Clinical Placements in Nursing Homes: An Interpretative Phenomenological Analysis. [PDF]

Int J Older People Nurs
Cooke J, Aveyard H, Greenway K, Schutz S.   +3 more
europepmc   +1 more source