Results 241 to 250 of about 142,923 (315)

Lilrb4a Suppression Reprograms Microglia to Mitigate APOE4‐Associated Amyloid Plaques and Cerebral Amyloid Angiopathy in Association With a PPAR‐Linked Pro‐Clearance State

Advanced Science, EarlyView.
Targeting Lilrb4a in Apolipoprotein E4 (APOE4)‐associated Alzheimer's disease (AD) reprograms microglia toward a beneficial, phagocytic state. Genetic deletion or antisense inhibition of Lilrb4a suppresses p‐SHP2/NF‐κB/STAT1 signaling, restores PPAR‐linked lipid and energy metabolism, and reduces amyloid plaque burden and cerebral amyloid angiopathy ...
Changxu Nie, Ruixi Yang, Xiaotong Wang, Ping Jia, Xueqi Zhang, Yaqi Dai, Xue Bai, Sijia Duan, Yufeng Li, Peng Zheng, Xin Tian, Li Jiang, Chao Wang   +12 more
wiley   +1 more source

Prevalence and patterns of e-cigarette use among school-aged adolescents in Peru, 2024. [PDF]

Tob Induc Dis
Vargas-Fernández R, Hernández-Vásquez A.   +1 more
europepmc   +1 more source

Endogenous Engineering Reprograms Extracellular Vesicles for Enhanced Therapeutic Function

Advanced Science, EarlyView.
This review explains how Extracellular vesicles‐producing cells can be endogenously engineered to load therapeutic proteins and nucleic acids. We summarize physiological and genetic strategies that harness native sorting pathways for selective cargo loading.
Jinghui Wang, Wenxuan Zhao, Xiaoming Hu, Yishu Wang, Peidong Yang, Diwei Zheng, Yugang Wang, Guanghui Ma, Min Shi, Wei Wei, Shuang Wang   +10 more
wiley   +1 more source

Social isolation by housing type 6 years after the Great East Japan Earthquake in Iwate prefecture: longitudinal findings from the Tohoku Medical Megabank community-based cohort study. [PDF]

BMJ Public Health
Kotozaki Y, Akasaka H, Otsuka K, Tanno K.   +3 more
europepmc   +1 more source

Spontaneous Non‐Catalyzed Molecular Reactions and Interactions in the Human Body: Biomedical Implications

Advanced Science, EarlyView.
ABSTRACT The human body functions as a natural reactor for a vast network of chemical and biological reactions and physical interactions among small molecules, proteins, cells, and numerous other components. These reactions/interactions are essential for maintaining normal physiological functions.
Yuhao Cai, Chao Zhao
wiley   +1 more source

Delirium in German Nursing Homes - a qualitative study of care practice from the perspective of nurses and general practitioners. [PDF]

BMC Geriatr
Kömp M, Lauer R, Molitor V, Busse TS, Flemm C, Vollmar HC, Thürmann P, Holle B, Palm R, Otte IC.   +9 more
europepmc   +1 more source

Home over institution? New insights on older adults' care preferences from a mixed-methods study in France. [PDF]

PLoS One
Cheneau A, Sicsic J, Rapp T.
europepmc   +1 more source

Lessons learned from social isolation in nursing homes during the COVID-19 epidemic-group interview with relatives with negative experiences. [PDF]

BMC Geriatr
Skela-Savič B, Pivač S, Squires A.
europepmc   +1 more source

Human-animal interactions: starting with pets of children with cerebral palsy. [PDF]

BMC Complement Med Ther
Rosales M, Rittler A, Heathcock J.
europepmc   +1 more source

Decreases in influenza vaccination coverage among nursing home healthcare workers and in measures to promote influenza vaccination, France, 2007/08 to 2024/25. [PDF]

Euro Surveill
Hanguehard R, Fonteneau L, Bonnet N, Levy-Bruhl D, Parent-du-Châtelet I, Vaux S.   +5 more
europepmc   +1 more source