Results 31 to 40 of about 434,166 (195)

Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren, Moana Busch, Pedro A. Ruiz, Ermanno Malagola, Valeria Baumeler, Federica Foti, Adelina Gross, Tobias Grütter, Hendrik Edel, Cordelia Schuler, Kristina Handler, Glenn De Lange, Isabelle C. Arnold, Cheryl de Vallière, Klaus Seuwen, Martin Hausmann, Gerhard Rogler   +16 more
wiley   +1 more source

Increasing prehospital emergency medical service interventions for nursing home residents. [PDF]

, 2015
QUESTION: In the ageing European population, the proportion of interventions by the emergency medical services (EMS) for elderly patients is increasing, but little is known about the recent trend of EMS interventions in nursing homes.
Burnand, B., Carron, P.N., Dami, F., Pittet, V., Toppet, V., Yersin, B.   +5 more
core   +1 more source

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

Central monitoring system for ambient assisted living [PDF]

, 2018
Smart homes for aged care enable the elderly to stay in their own homes longer. By means of various types of ambient and wearable sensors information is gathered on people living in smart homes for aged care.
Kaur, Manbir
core  

Briefly noted: The training of carers in homes for the aged [PDF]

, 1995
Few homes for the aged are able to staff a frail-care facility entirely with professional nursing staff. For this reason most homes have a staff mix of a few nursing sisters supported by less qualified personnel such as enrolled nursing auxiliaries, who ...
Tooke, J.R.H.
core   +2 more sources

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

The Mediating Role of Staffing on Quality of Care in Nonprofit and For-Profit Nursing Homes in Indiana [PDF]

, 2017
This study attempts to disentangle the relationships between ownership, staffing, and nursing home quality using Indiana nursing home data. Typical Indiana nursing homes are known to be below average on health inspection and overall quality ratings. This
Gichungeh, Irene, Kim, Ae-Sook
core   +1 more source

An open chat with…Pierre Santucci: a testimonial on why we should engage with scientific societies and their journals

FEBS Open Bio, Volume 15, Issue 6, Page 894-897, June 2025.
Pierre SANTUCCI is a principal investigator at the CNRS—Aix Marseille Université and recipient of a FEBS Excellence Award. He was also recently appointed FEBS Open Bio Publishing Liaison Officer. In this Open Chat with…, he discusses the importance of engaging with scientific societies and their journals, and highlights through some of his personal ...
Pierre Santucci, Ioannis Tsagakis
wiley   +1 more source

Development of 4T1 breast cancer mouse model system for preclinical carbonic anhydrase IX studies

FEBS Open Bio, EarlyView.
Carbonic anhydrase IX (CAIX) is a well‐recognised therapeutic target and prognostic biomarker in cancer. We developed and characterised a robust murine breast cancer model system that is suitable for CAIX studies in vitro and in vivo—it comprises both CAIX‐positive and CAIX‐negative controls and provides a solid platform for the comprehensive ...
Zane Kalniņa, Ilva Liekniņa, Svetlana Koteloviča, Ramona Petrovska, Gediminas Žvinys, Agne Petrosiute, Asta Zubrienė, Matīss Toms Laugalis, Vendija Skeltona, Juris Jansons, Madara Kreishmane, Edita Čapkauskaitė, Daumantas Matulis, Kaspars Tārs   +13 more
wiley   +1 more source

Towards better understanding of factors contributing to medical physicist well‐being in academic medical centers: A systems‐analysis approach

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract The well‐being of medical physicists can impact overall system performance, patient safety, and quality of patient care. There are limited formal assessments of factors contributing to physicists well‐being. Nine medical physicists at a US academic medical center were surveyed on 21 workplace factors, drawn from the National Academy of ...
Elizabeth Kwong, Chao Chin Liu, Karthik Adapa, Lisa Vizer, Brian Anderson, Damian McHugh, Todd Pawlicki, Moyed Miften, Amit Sawant, Nadia Charguia, Shiva Das, Lawrence B. Marks, Jean L. Wright, Lukasz Mazur   +13 more
wiley   +1 more source