Results 51 to 60 of about 142,923 (315)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Models of general practitioner services in residential aged care facilities [PDF]

, 2015
Describes different models for general practice care for patients in residential aged care facilities. Background Provision of timely and high-quality general practitioner (GP) services to patients in residential aged care facilities (RACFs) is ...
Richard Reed
core  

Quality of life of elderly people living in a retirement home [PDF]

Vojnosanitetski Pregled, 2016
Background/Aim. The World Health Organization (WHO) identified four broad domains as being universally relevant to the quality of life, namely physical, and psychological health, social relationships, and environment.
Čanković Sonja, Nikolić-Ač Eržebet, Jovanović Mijatović Vesna, Kvrgić Svetlana, Harhaji Sanja, Radić Ivana   +5 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Nursing Process for institutionalized older adults: contributions from knowledge awareness workshop [PDF]

Revista Brasileira de Enfermagem
Objective: To analyze the knowledge of professionals working in a Nursing Home about the Nursing Process before and after the awareness workshop. Methods: This is strategic action research, developed with nursing professionals and managers of a Nursing ...
Francisco Fernandes, Francine Casarin, Patrícia Bitencourt Toscani Greco, Dirce Stein Backes, Oclaris Lopes Munhoz, Silomar Ilha   +5 more
doaj   +1 more source

The fear of falls in the caregivers of institutionalized elders

Revista Gaúcha de Enfermagem, 2021
Aims To understand how the fear of falls emerges and manifests itself in caregivers of institutionalized elders. Method It is a qualitative study, based on the Grounded Theory and carried out with 24 informal caregivers, 5 nurses, 2 physicians and 2 ...
Cristina Lavareda Baixinho, Maria dos Anjos Dixe, Maria Adriana Henriques, Cristina Marques-Vieira, Luis Sousa   +4 more
doaj   +2 more sources

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Intrinsic capacity as proposed by the World Health Organization and 30-month mortality among older adults in long-term care facilities

Geriatrics, Gerontology and Aging
Objective: To analyze the impact of intrinsic capacity on 30-month mortality among older adults living in long-term care facilities (LTCFs). Methods: Prospective cohort study with survival analysis conducted from July 2020 to December 2022 among older ...
Adriana Polachini do Valle, Tatiane Cristina de Carvalho, Antonio Rodrigues Bueno da Fonseca, Thamires Auxiliadora Oyan, Mariana Gegenheimer Bremenkamp, José Vitor Polachini do Valle Villas Boas, Paulo José Fortes Villas Boas   +6 more
doaj   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

CARE-PACT: a new paradigm of care for acutely unwell residents 
in aged care facilities [PDF]

, 2015
Describes the Comprehensive Aged Residents Emergency and Partners in Assessment, Care and Treatment (CARE-PACT) program: a hospital substitutive care and demand management project that aims to improve, in a fiscally efficient manner, the quality of care ...
Burkett, Ellen, Ellen Burkett, Scott, Ian, Ian Scott   +3 more
core