Results 61 to 70 of about 135,110 (266)

Cambios en la depresión y el sentimiento de soledad después de la terapia de la risa en adultos mayores internados

Biomédica: revista del Instituto Nacional de Salud, 2015
Introducción. La vejez es una etapa que está enmarcada por una serie de fenómenos que inciden de forma negativa en la vida de las personas, entre otros, el sentimiento de soledad y la depresión. Objetivo. Evaluar el impacto de la terapia de la risa sobre
Ángela Quintero, María Eucaris Henao, María Mercedes Villamil, Jairo León   +3 more
doaj   +1 more source

Prevalence, pattern, and compliance with spectacles use among the elderly in homes for the aged in South India: The Hyderabad Ocular Morbidity in Elderly Study (HOMES). [PDF]

Indian J Ophthalmol, 2023
Marmamula S, Bhoopalan D, Kumbham TR, Yelagondula VK, Keeffe J.   +4 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Idosos residentes em instituições de longa permanência para idosos da região metropolitana de Belém-PA

Revista Brasileira de Geriatria e Gerontologia
Estudo exploratório-descritivo realizado em quatro instituições de longa permanência para idosos (ILPI), duas filantrópicas e duas governamentais, na região metropolitana de Belém, PA.
Sandra Helena Isse Polaro, Joana Cleia Trindade Fideralino, Priscila Araújo de Oliveira Nunes, Elisa da Silva Feitosa, Lucia Hisako Takase Gonçalves   +4 more
doaj   +1 more source

Visual outcomes after cataract surgery among the elderly residents in the 'homes for the aged' in South India: the Hyderabad Ocular Morbidity in Elderly Study. [PDF]

Br J Ophthalmol, 2021
Marmamula S, Barrenakala NR, Challa R, Kumbham TR, Modepalli SB, Yellapragada R, Bhakki M, Reddy JC, Friedman DS, Khanna RC.   +9 more
europepmc   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Health multidimensional evaluation of institutionalized older adults according to cognitive performance [PDF]

Dementia & Neuropsychologia
. The assessment of living and health conditions of the institutionalized older adults contributes to the development of health promotion measures. The high prevalence of cognitive decline in this population leads to unfavorable health outcomes, which ...
Beatriz Cintra Martins, Lilian Barbosa Ramos, Anna Karla Carneiro Roriz, Henrique Salmazo da Silva   +3 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Care for the spiritual dimension provided by caregivers in a nursing home

Revista Brasileira de Enfermagem
Objectives: to understand care for the spiritual dimension provided by caregivers in a Nursing Home. Methods: this is a qualitative research, carried out in a geriatric center of a philanthropic hospital in the city of Salvador, Bahia.
Lucivalda Barbosa Santos, Tânia Maria de Oliva Menezes, Raniele Araújo de Freitas, Marta Gabriele Santos Sales, Ana Luíza Barreto de Oliveira, Amélia Maria Pithon Borges Nunes   +5 more
doaj   +2 more sources