Results 81 to 90 of about 206,626 (266)

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

open access: yesAdvanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel   +16 more
wiley   +1 more source

Learning Contracts in Undergraduate Courses: Impacts on Student Behaviors and Academic Performance

open access: yesJournal of the Scholarship of Teaching and Learning, 2013
This project studied the effect of individualized, voluntary learning contracts for 18 students who performed poorly in the first part of the semester.
Timothy Frank, Lauren L.F. Scharff
doaj  

What\u27s Wrong With American Secondary Schools: Can State and Federal Governments Fix it? [PDF]

open access: yes, 1990
[Excerpt] The poor performance of American students is sometimes blamed on the nation\u27s diversity . Many affluent parents apparently believe that their children are doing acceptably by international standards. This is not the case.
Bishop, John H.
core   +1 more source

Neuid: A Novel Neuron‐Enriched LncRNA that Connects Epigenetic Gene Silencing to Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
ABSTRACT The increasing evidence that non‐coding RNAs can become deregulated during pathogenesis is dramatically expanding the space for drug discovery beyond the protein‐coding genome. Long noncoding RNAs (lncRNAs) are emerging as key regulators of cellular function, yet most remain uncharacterized.
Ranjit Pradhan   +17 more
wiley   +1 more source

Central exit examinations increase performance ...: But take the fun out of mathematics [PDF]

open access: yes, 2008
In response to PISA, all German federal states but one have adopted central exit examinations (CEEs) at the end of all secondary school tracks. Theoretically, the advantages of CEEs are fairly undisputed. CEEs make teaching and learning output observable
Jürges, Hendrik, Schneider, Kerstin
core  

DOT1L Drives Endothelial‐to‐Mesenchymal Transition and Fibrotic Vascular Remodeling via H3K79 Methylation

open access: yesAdvanced Science, EarlyView.
DOT1L as a central epigenetic regulator of EndoMT and pulmonary fibrosis. Acting as an early epigenetic switch, it translates TGFβ–SMAD signaling into H3K79me2‐mediated chromatin remodeling, selectively activates fibrosis‐related genes, and primes ECs for rapid mesenchymal transition.
Yaofeng Wang   +11 more
wiley   +1 more source

Construction and validation of the scale of dysfunctional motivational beliefs in high school students

open access: yesمجله علوم روانشناختی, 2023
Background: Ineffective motivational beliefs refer to the tendency of people to evaluate performance according to low criteria and lack of effort and perseverance to succeed in homework.
Ashraf Qelich Beiki   +2 more
doaj  

De Novo Multi‐Mechanism Antimicrobial Peptide Design via Multimodal Deep Learning

open access: yesAdvanced Science, EarlyView.
Current AI‐driven peptide discovery often overlooks complex structural data. This study presents M3‐CAD, a generative pipeline that leverages 3D voxel coloring and a massive database of over 12 000 peptides to capture nuanced physicochemical contexts.
Xiaojuan Li   +23 more
wiley   +1 more source

SINERGI PEMERINTAH DAN PERUSAHAAN PADA AKTIVITAS CSR DALAM RANGKA MENGHADAPI MEA

open access: yesJurnal Kawistara, 2018
Corporate Social Responsibility activities ideally be felt by the West Bandung Regency, where The West Bandung Regency has now transformed into an industrial area.
Kokom Komariah   +3 more
doaj   +1 more source

Educational Reform and Disadvantaged Students: Are They Better Off or Worse Off? [PDF]

open access: yes, 2004
This paper analyzes the effects of increased academic standards on both average achievement levels and on equality of opportunity. The five policies evaluated are: (1) universal curriculum-Based External Exit Exam Systems, (2) voluntary curriculum-based ...
Bishop, John H., Mane, Ferran
core   +1 more source

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