Results 91 to 100 of about 206,626 (266)

CRP Deficiency Rescues Periodontitis‐Induced Hippocampal Neurogenesis Impairment by Suppressing OPC‐Derived BMP4 Signaling in Rats

Advanced Science, EarlyView.
Chronic periodontitis elevates circulating CRP, which enters the hippocampus to upregulate BMP4 in oligodendrocyte precursor cells (OPCs), thereby impairing neurogenesis and inducing anxiety/depression‐like behaviors in rats. Counteracting this pathway, CRP deficiency helps confer functional resilience to OPCs.
Lingjie Li, Ping Deng, Siyu Hou, Xianbo Xia, Wei Zhao, Xingyu Zhu, Yang Zhang, Chao Wang, Ling Xu, Jinlin Song   +9 more
wiley   +1 more source

Experiences and Thoughts on STEMTEC-Inspired Changes in Teaching Physics for Life Science Majors [PDF]

, 2000
I have taught an introductory course for life science majors three times, each time introducing one or more teaching techniques discussed during the Science, Technology, Engineering, and Mathematics Teaching Education Collaborative (STEMTEC) meetings ...
Rabin, M. S. Z.
core   +1 more source

Reinventing College Physics for Biologists: Explicating an epistemological curriculum

, 2008
The University of Maryland Physics Education Research Group (UMd-PERG) carried out a five-year research project to rethink, observe, and reform introductory algebra-based (college) physics.
David Hammer, Edward F. Redish, Giroux H. A., Goertzen R. M., Hammer D., Hatano G., Mazur E., McCloskey Michael, McDermott L., Redish E. F., Redish E. F., Schachter D., Schoenfeld A. H., Strike K. A., Varmus H., Wittmann M.   +15 more
core   +1 more source

A Tac1‐Expressing Brainstem Pathway Underlies the Pathogenesis of Trigeminal Neuralgia

Advanced Science, EarlyView.
A critical TG‐Sp5CTac1‐PBNTac1 pathway drives trigeminal neuropathic pain (TNP). Tac1‐expressing parabrachial nucleus (PBNTac1) neurons exhibit heightened responses to innocuous stimuli in TNP, and chemogenetic inhibition of these neurons effectively prevents TNP development.
Liting Sun, Jia‐Jia Wang, Xiang‐Yu Li, Xin‐Yi Lin, Juan Li, Qiu‐Tong Yu, Zi‐Han Wang, Xue‐Ping Gao, Lei Jin, Wei‐Ke Li, Tian‐Lin Cheng, Juan Deng   +11 more
wiley   +1 more source

Use of the World Wide Web in Mathematics Instruction [PDF]

, 2000
Many mathematics instructors may find they can use the World Wide Web to distribute information and facilitate discussion and interaction in their classrooms, while actually reducing their administrative workload.
Lewis, A.
core   +1 more source

Evaluating the relative contribution of patient effort and therapist skill in integrating homework into treatment for posttraumatic stress disorder.

Psychological Trauma: Theory, Research, Practice, and Policy
Homework has historically been an integral component of cognitive behavioral interventions for posttraumatic stress disorder (PTSD). Previous studies differ in the measurement of therapy homework, resulting in inconsistent conclusions about its contributions to symptom reduction. Given the methodological burden associated with examining therapist skill
Mercedes G. Woolley, Brian N. Smith, Rachel L. Micol, Courtney C. Farmer, Tara E. Galovski   +4 more
openaire   +2 more sources

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

An Online Tutor for Astronomy: The GEAS Self-Review Library

, 2015
We introduce an interactive online resource for use by students and college instructors in introductory astronomy courses. The General Education Astronomy Source (GEAS) online tutor guides students developing mastery of core astronomical concepts and ...
Muise, Amy Smith, Vogt, Nicole P.
core   +2 more sources

Sphingomonas paucimobilis‐Driven Epithelial–Endothelial Transition in Adenomyosis Pathogenesis

Advanced Science, EarlyView.
This study identifies epithelial–endothelial transition (EET) as a novel adenomyosis pathogenic mechanism driven by Sphingomonas paucimobilis colonization. Systematic inhibitor experiments validate a TNFα→NF‐κB→MMP signaling cascade essential for EET. Critically, bacterial culture supernatant fails to induce pathological changes, demonstrating viable ...
Peigen Chen, Hao Shi, Junxian He, Ziyu Liu, Yuanyuan Zhu, Xiaoyan Liang, Guihua Liu, Xing Yang   +7 more
wiley   +1 more source

Question-based Writing Process: A Reflection and a Proposal to L2 Writing

HOW, 2017
This article focuses on the problem of writing as it has been traditionally approached without reference to the learners' interests and expectations. Also, due to the fact that it demands considerable time and effort it has been regarded as homework. Due
Ruth Angela Ortiz
doaj