Results 101 to 110 of about 703,597 (255)
Open Chemistry, 2017 (5-Methoxy-1H-indol-1-yl)(5-methoxy-1H-indol-2-yl)methanone (MIMIM) is a bis-indolic derivative that can be used as a precursor to a variety of melatonin receptor ligands.
Al-Wabli Reem I. +3 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Homo- and Heteroannularly Bridged Ferrocenyl Diphosphines in Asymmetric Hydrogenations
, 2016 Four new enantiopure homo- and heteroannularly bridged ferrocenyl diphosphine ligands have been synthesized, characterized, and tested in enantioselective hydrogenations of olefins [methyl-(Z)-(α)-(acetamido)cinnamate, (Z)-(α)-methylcinnamic acid and ...
Félix A. Jalón (2440021) +6 more
core +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Une nouvelle histoire de l'empire romain
, 1939 Homo Léon. Une nouvelle histoire de l'empire romain. In: Journal des savants, Juillet-août 1939. pp.
Homo, Léon
core +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Le domaine impérial à Rome. Ses origines et son développement du Ier au IVe siècle
, 1899 Homo Léon. Le domaine impérial à Rome. Ses origines et son développement du Ier au IVe siècle. In: Mélanges d'archéologie et d'histoire, tome 19, 1899. pp.
Homo, Léon
core +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Les suffètes de Thugga d'après une inscription récemment découverte
, 1899 Homo Léon. Les suffètes de Thugga d'après une inscription récemment découverte. In: Mélanges d'archéologie et d'histoire, tome 19, 1899. pp.
Homo, Léon
core +1 more source