Results 81 to 90 of about 703,597 (255)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Les mages hellénisés Ostanés et Zoroastre

open access: yes, 1939
Homo Léon. Les mages hellénisés Ostanés et Zoroastre. In: Journal des savants, Juillet-août 1939. pp.
Homo, Léon
core   +1 more source

Evidence of lead poisoning and the co-occurrence of metabolic disease in Archaic/Early Classical (6th–5th century BCE) Laurion, Greece

open access: yesHomo
Lead is one of the most toxic heavy metals and environmental pollutants on earth capable of adversely affecting every organ in the human body, with harmful short- and long-term effects. In the Laurion region of southeastern Attica, Greece, the extraction
Anna Lagia   +2 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

QUANTUM CHEMICAL STUDY ON TWO BENZIMIDAZOLE DERIVATIVES

open access: yesJournal of Amasya University the Institute of Sciences and Technology, 2020
A quantum theoretical study was done on two of benzimidazole derivatives to calculate the energetic behavior of the compounds in the gas phase, where (the density functional theory (DFT), Becke’s three-parameter exchange function and the Lee-Yang-Parr ...
Fatma Kandemirli   +2 more
doaj  

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

La maison de l'empereur Tétricus à Rome

open access: yes, 1914
Homo Léon. La maison de l'empereur Tétricus à Rome. In: Revue des Études Anciennes. Tome 16, 1914, n°2. pp.
Homo, Léon
core   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

open access: yesFEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani   +3 more
wiley   +1 more source

Walter Fabers Welt - und Selbstbild und seine Wandlung in Max Frischs Roman Homo faber

open access: yes, 2017
Meine Abschlussarbeit beschäftigt sich mit Max Frischs Roman Homo faber. Ich fokussiere mich auf die Weltanschauung des Protagonisten und dessen ständige Veränderung.BKgermanisztika-németBSc ...
Kiss, Georgina Anna
core  

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