Results 151 to 160 of about 143,735 (277)

コーヒー／カフェイン摂取と日常生活－循環器・消化器系機能に及ぼす影響評価－ [PDF]

, 2018
循環器・消化器系機能に及ぼすコーヒー／カフェイン摂取の影響ついて、これまでの知見を総括した。中程度のコーヒー摂取は、冠動脈疾患や急性心不全のリスクを高めることはなく、女性ではむしろ、急性心不全の発症リスクを低下することが示唆されている。さらに、コーヒー摂取は高血圧リスクを高めないとする報告が多い。コレステロールレベルについては、コーヒーの抽出方法に強く依存している。現時点では、コーヒー摂取と消化器症状、上部食道炎、胃・十二指腸潰瘍、胃がんの発症、あるいはこれらの症状の悪化との関連は把握されていない ...
栗原, 久
core  

Homocysteine in chronic kidney disease: Clinical diagnostic aspects

, 2023
И. Т. Муркамилов, К. А. Айтбаев, В. В. Фомин, Ж. А. Муркамилова, Indira Kudaibergenova, F. А. Yusupov, З. А. Aйдаров   +6 more
openalex   +2 more sources

No Increased Risk of Thromboembolic Events During 6‐Month Treatment With Baricitinib in Patients With Alopecia Areata

International Journal of Dermatology, EarlyView.
Giacomo Caldarola, Antonietta Ferretti, Lorenzo Maria Pinto, Leonardo Di Gennaro, Eleonora De Luca, Gennaro Marco Falco, Clara De Simone, Raimondo De Cristofaro, Ketty Peris   +8 more
wiley   +1 more source

Development of a Continuous, Uncoupled Fluorescence‐based Assay for Monitoring Methyltransferase Activity: Methylation Going Sour

ChemCatChem, Volume 18, Issue 3, 12 February 2026.
Methylation going sour: The first uncoupled fluorescence‐based assay was established to measure methyltransferase activity in a continuous fashion. Different use cases are presented, including the assay's compatibility with catalyst formulations other than purified enzymes, the determination of kinetic parameters, as well as the screening of a ...
Benjamin Panagiotis Chapple, Lisa M. Böhmer, Jörg Pietruszka   +2 more
wiley   +1 more source

High‐throughput single‐cell DNA methylation and chromatin accessibility co‐profiling with SpliCOOL‐seq

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
SpliCOOL‐seq achieves high‐throughput single‐cell co‐profiling of DNA methylation and chromatin accessibility. DNMT inhibitors caused cancer cell demethylation with divergent patterns. SpliCOOL‐seq enables the discovery of genes related to LUAD tumorigenesis. Ageing and LUAD tumorigenesis may share similar epigenetic alterations.
Qingmei Shen, Enze Deng, Ling Luo, Jingna Zhang, Qifeng Yang, Dan Su, Xiaoying Fan   +6 more
wiley   +1 more source

Low physical activity and high homocysteine levels among doctors

Global Journal of Medicine and Public Health
Background Homocysteine is a recognized risk factor for cardiovascular disease. Less is known about the influence of physical activity in homocysteine levels.
Roshni H Babu, Genga S, Kailasanathan C P   +2 more
doaj  

Mechanism of action and impact of thiol homeostasis on efficacy of an enzyme replacement therapy for classical homocystinuria

Redox Biology
Homocystinuria (HCU) due to cystathionine beta-synthase (CBS) deficiency is characterized by elevated plasma and tissue homocysteine levels. There is no cure, but HCU is typically managed by methionine/protein restriction and vitamin B6 supplementation ...
Thilo Magnus Philipp, Teodoro Bottiglieri, Wilmelenne Clapper, Kai Liu, Steve Rodems, Csaba Szabo, Tomas Majtan   +6 more
doaj   +1 more source

Lifespan‐Extending Endogenous Metabolites

Aging Cell, Volume 25, Issue 2, February 2026.
Endogenous metabolites act as mediators of longevity by modulating conserved cellular pathways. We summarize mechanistic evidence linking specific metabolites to lifespan and healthspan benefits across model systems, with discussion of clinical evidence, translational opportunities, and remaining knowledge gaps.
Yizhou Jiang, Jing‐Dong J. Han
wiley   +1 more source

N-Acyl l-Homocysteine Thiolactones Are Potent and Stable Synthetic Modulators of the RhlR Quorum Sensing Receptor in Pseudomonas aeruginosa [PDF]

, 2019
Michelle E. Boursier, Joshua B. Combs, Helen E. Blackwell   +2 more
openalex   +1 more source

Selection for Postponed Senescence in Drosophila melanogaster Reveals Distinct Metabolic Aging Trajectories Modifiable by the Angiotensin‐Converting Enzyme Inhibitor Lisinopril

Aging Cell, Volume 25, Issue 2, February 2026.
Assessment of oxygen consumption rates in young, middle‐aged, and old flies from the Drosophila B lines and long‐lived O lines revealed a significant increase in metabolic rate with aging only in B flies. Lisinopril prevented the age‐related rise in metabolic rate in B female flies.
Denise Vecchié, Robert R. H. Anholt, Trudy F. C. Mackay, Maria De Luca   +3 more
wiley   +1 more source