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Measurement of plasma total homocysteine by HPLC with coulometric detection.

open access: bronze, 1999
Steven C. Martin   +3 more
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Homocysteine

Critical Reviews in Clinical Laboratory Sciences, 1999
Homocysteine is a sulfur-containing amino acid generated through the demethylation of methionine. It is largely catabolized by trans-sulfuration to cysteine, but it may also be remethylated to methionine. Regulation of homocysteine is dependent on nutrient intake, especially folate, vitamins B6 and B12.
L J, Langman, D E, Cole
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Homocysteine

Comprehensive Therapy, 2002
Homocystemia is a pathological condition that represents a significant role in cardiovascular morbidity and mortality. The epidemiology, pathophysiology, and clinical diagnostics and treatment aspects are described and discussed.
Robert Hasty, Edward N. Smolar
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Homocysteine and Gliotoxicity

Neurotoxicity Research, 2021
Homocysteine is a sulfur amino acid that does not occur in the diet, but it is an essential intermediate in normal mammalian metabolism of methionine. Hyperhomocysteinemia results from dietary intakes of Met, folate, and vitamin B12 and lifestyle or from the deficiency of specific enzymes, leading to tissue accumulation of this amino acid and/or its ...
Angela T. S. Wyse   +3 more
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Homocysteine

The International Journal of Biochemistry & Cell Biology, 2000
Homocysteine does not occur in the diet but it is an essential intermediate in normal mammalian metabolism of methionine. Each compound, methionine or homocysteine, is the precursor of the other. Similarly, the synthesis of one is the mechanism for the detoxification of the other.
J D, Finkelstein, J J, Martin
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Homocysteine

Clinics in Laboratory Medicine, 2006
Elevated homocysteine levels are associated with a variety of vascular diseases. Specifically, hyperhomocysteinemia is a risk factor for coronary artery disease, cerebrovascular disease, and peripheral arterial disease. Laboratory-based strategies for its detection and quantification have evolved to meet the increasing need for accuracy in risk ...
Bradley A, Maron, Joseph, Loscalzo
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